Results 11 to 20 of about 89,193 (344)

Extracellular vesicles protect glucuronidase model enzymes during freeze-drying [PDF]

Scientific Reports, 2018
Extracellular vesicles (EVs) are natural nanoparticles that play important roles in intercellular communication and are increasingly studied for biosignalling, pathogenesis and therapy.
J. Frank, Maximilian Richter, C. de Rossi, C. Lehr, Kathrin Fuhrmann, G. Fuhrmann   +5 more
semanticscholar   +2 more sources

Investigation of the inhibitory potential of secondary metabolites isolated from Fernandoa adenophylla against Beta-glucuronidase via molecular docking and molecular dynamics simulation studies. [PDF]

PLoS ONE
Elevated β-glucuronidase activity is associated with the production of toxic metabolites that contribute to tumor development and other diseases. Inhibiting this enzyme may offer therapeutic potential, including the prevention of colonic carcinogenesis ...
Abdur Rauf, Rahaf Ajaj, Zuneera Akram, Majid Khan, Abdul Wadood, Maryam Zulfat, Zafar Ali Shah, Abdulhakeem S Alamri, Walaa F Alsanie, Majid Alhomrani, Humaira Hussain, Dorota Formanowicz   +11 more
doaj   +2 more sources

Evaluation of the gut microbiome and sex hormones in postmenopausal women with newly diagnosed hormone receptor-positive breast cancer versus healthy women: a prospective case-control study [PDF]

Journal of Cancer Research and Clinical Oncology
Purpose The functional composition and diversity of the gut microbiome may affect breast cancer risk by modulation of systemic sex hormones. Gut bacteria with β-glucuronidase enzymatic activity may deconjugate estrogens, leading to increased estrogen ...
Maryann Kwa, Grant Hussey, Yelena Novik, Adrian A. Franke, Angelina Volkova, Karina Flores, Martin J. Blaser, James Speyer, Ruth Oratz, Marleen Meyers, Komal Jhaveri, Ezeddin Fadel, Adriana Heguy, Jonas Schluter, Kelly V. Ruggles, Sylvia Adams   +15 more
doaj   +2 more sources

Phenoxyacetohydrazide Schiff Bases: β-Glucuronidase Inhibitors

Molecules, 2014
Phenoxyacetohydrazide Schiff base analogs 1–28 have been synthesized and their in vitro β-glucouoronidase inhibition potential studied. Compounds 1 (IC50 = 9.20 ± 0.32 µM), 5 (IC50 = 9.47 ± 0.16 µM), 7 (IC50 = 14.7 ± 0.19 µM), 8 (IC50 = 15.4 ± 1.56 µM),
Waqas Jamil, Shagufta Perveen, Syed Adnan Ali Shah, Muhammad Taha, Nor Hadiani Ismail, Shahnaz Perveen, Nida Ambreen, Khalid M. Khan, Muhammad I. Choudhary   +8 more
doaj   +2 more sources

Incidence of Escherichia coli  - Glucuronidase Positive on Goat Milk

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Agriculture, 2016
Papers on beta- glucuronidase sensitivity and specificity for identifying Escherichia coli in sources of environment, food, water, etc. have been published since 1976. In this study we conducted a review of the incidence of E.
Zorica Voşgan, Anca Domuţa, Stela Jelea, Lucia Mihălescu, Flavia Pop   +4 more
doaj   +3 more sources

Agrobacterium-Mediated Stable Transformation of Medicinal Plant Andrographis paniculata Callus Expressing β-glucuronidase (GUS) Gene

Indonesian Journal of Biotechnology, 2015
This study was carried out to establish a stable genetic transformation in callus culture of Andrographispaniculata mediated by Agrobacterium tumefaciens. The leaf disks of A. paniculata were infected with A.
Erly Marwani, Agustina Tangapo, Fenny Martha Dwivany   +2 more
doaj   +1 more source

A comparative study of Tam3 and Ac transposition in transgenic tobacco and petunia plants [PDF]

, 1989
Transposition of the Anthirrinum majus Tam3 element and the Zea mays Ac element has been monitored in petunia and tobacco plants. Plant vectors were constructed with the transposable elements cloned into the leader sequence of a marker gene ...
A Day, A Herrmann, A Hoekema, A Hudson, AH Shirsat, B Baker, B Baker, C Martin, C Martin, C O'Reilly, Caius M. T. Rommens, D Inzé, DC Baulcombe, F Sanger, G Ditta, H Sommer, H. John J. Nijkamp, J Gielen, J Paz-Ares, Jacques Hille, JDG Jones, JI Yoder, Jie Gao, JM Goddard, KC Cone, LO Vodkin, M Motto, M-A Grandbastien, MA Sluys Van, Michel A. Haring, NV Fedoroff, P Maliga, P Nevers, P Vlaming De, R Carpenter, RA Jefferson, S Knapp, SL Dellaporta, T Maniatis, Tjeerd Volbeda, U Behrens, WD Sutton   +41 more
core   +12 more sources

Production and Characterization of the Beneficial β-glucuronidase Inhibitor from non pathogenic wild yeast, Candida oleophila WP5-19-1, and its effects on gut microbes

한국균학회지, 2022
We aimed to produce a potent β-glucuronidase inhibitor from wild yeast that could inactivate toxic substances in the colon. Culture supernatants and cell-free extracts of non-pathogenic wild yeasts were prepared and their β-glucuronidase inhibitory ...
Seon-Jeong Park, Jong-Soo Lee
doaj   +1 more source

Fecal β-glucuronidase activity differs between hematopoietic cell and kidney transplantation and a possible mechanism for disparate dose requirements

Gut Microbes, 2022
The intestinal microbiota produces β-glucuronidase that plays an essential role in the metabolism of the immunosuppressant mycophenolate mofetil (MMF). This drug is commonly used in organ and hematopoietic cell transplantation (HCT), with variations in ...
Mohammad Haneef Khan, Guillaume C. Onyeaghala, Armin Rashidi, Shernan G. Holtan, Alexander Khoruts, Ajay Israni, Pamala A. Jacobson, Christopher Staley   +7 more
doaj   +1 more source

Inhibitory Effect of Coumarins and Isocoumarins Isolated from the Stems and Branches of Acer mono Maxim. against Escherichia coli β-Glucuronidase

Applied Sciences, 2022
We isolated eight known secondary metabolites, including two isocoumarins and six coumarins, from the stems and branches of Acer mono Maxim. Their structures were confirmed using nuclear magnetic resonance spectroscopy and by comparing the data to ...
Nguyen Viet Phong, Byung Sun Min, Seo Young Yang, Jeong Ah Kim   +3 more
doaj   +1 more source