In vivo and in vitro metabolism of the designer benzodiazepine, bretazenil: a comparison of pooled human hepatocytes and liver microsomes with postmortem urine and blood samples. [PDF]
Arch ToxicolGameli PS +8 more
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Metabolic patterns of new psychoactive substances: Methyl-ketamine and 2-oxo-PCE in rats using UHPLC-QTOF analysis. [PDF]
Forensic Sci Int SynergCai YG +6 more
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Human metabolism and pharmacological profiling of protonitazepyne and metonitazepyne, two highly potent nitazenes: prediction of main metabolite activity based on µ-opioid receptor docking simulations. [PDF]
Arch ToxicolBerardinelli D +9 more
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A Novel Maturation Equation for Hepatic Clearance Across Preterm, Term Neonates, Children, and Adults: Application to Paracetamol and Its Metabolite. [PDF]
J Clin PharmacolWu Y +11 more
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Effect of Glucuronides on Glucuronide Biosnthesis
European Journal of Biochemistry, 19711‐Naphthyl and phenolphthalein glucuronides were found to be potent inhibitors of p‐nitro‐phenyl glucuronide synthesis catalyzed by rat liver microsomal fraction. They did not compete with theaglycone, p‐nitrophenol, but with glucuronyl donor, UDPglucuronic acid.
O, Hänninen, J, Marniemi
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Glucuronidation of apomorphine
Life Sciences, 2000Apomorphine, a dopaminergic receptor agonist, is largely used in the therapy of Parkinson's disease. In this study, we characterized the glucuronidation of apomorphine and other catechols in rat liver and brain microsomes, using UDP-[U-14C]glucuronic acid and separation of the glucuronides formed by a thin layer chromatographic method.
R S, El-Bachá +4 more
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