Results 11 to 20 of about 12,956 (251)

Adjunct Fenofibrate Up‐regulates Bile Acid Glucuronidation and Improves Treatment Response For Patients With Cholestasis

Hepatology Communications, 2021
Accumulation of cytotoxic bile acids (BAs) during cholestasis can result in liver failure. Glucuronidation, a phase II metabolism pathway responsible for BA detoxification, is regulated by peroxisome proliferator–activated receptor alpha (PPARα).
Gina M. Gallucci, Jocelyn Trottier, Christopher Hemme, David N. Assis, James L. Boyer, Olivier Barbier, Nisanne S. Ghonem   +6 more
doaj   +1 more source

Tethered Indoxyl-Glucuronides for Enzymatically Triggered Cross-Linking

Molecules, 2023
Indoxyl-glucuronides, upon treatment with β-glucuronidase under physiological conditions, are well known to afford the corresponding indigoid dye via oxidative dimerization.
Juno Son, Zhiyuan Wu, Jinghuai Dou, Hikaru Fujita, Phuong-Lien Doan Cao, Qihui Liu, Jonathan S. Lindsey   +6 more
doaj   +1 more source

Intestinal Glucuronidation, Prior to Hepatic Glucuronidation, Plays an Important Role in the Low Circulating Levels of Calycosin

Separations, 2022
Calycosin is a dietary flavonoid with favorable activities, which seems to be inconsistent with its low circulating levels in vivo. To address this issue, we developed a strategy to understand calycosin distribution by integrating qualitative and ...
Haodong Jiang, Huan Liu, Pei Hu, Shuoji Chen, Yaqing Ye, Chenggang Huang, Xiaoting Tian   +6 more
doaj   +1 more source

Synthetic β‑d‑Glucuronides: Substrates for Exploring Glucuronide Degradation by Human Gut Bacteria [PDF]

ACS Omega
Aleksandra Gorecka, Heidi Schacht, Megan K. Fraser, Aleksandra Teriosina, James A. London, Igor L. Barsukov, Andrew K. Powell, Alan Cartmell, Andrew V. Stachulski, Edwin A. Yates   +9 more
doaj   +2 more sources

Human UDP-glucuronosyltransferase UGT1A4 forms tertiary N-glucuronides predominately with the energetically less favored tautomer of substituted 1H-indazole (benzpyrazole)

Journal of Analytical Science and Technology, 2017
Background Human UDP-glucuronosyltransferase UGT1A4 is reported to convert a range of tertiary amine substrates to the respective quaternary glucuronides. In this study, we report on the in vitro glucuronidation of a substituted 1H-indazole (benzpyrazole)
Andreas Fredenhagen, Fabian K. Eggimann, Matthias Kittelmann, Thomas Lochmann, Jürgen Kühnöl   +4 more
doaj   +1 more source

Mitochondrial dysfunction leads to deconjugation of quercetin glucuronides in inflammatory macrophages. [PDF]

PLoS ONE, 2013
Dietary flavonoids, such as quercetin, have long been recognized to protect blood vessels from atherogenic inflammation by yet unknown mechanisms. We have previously discovered the specific localization of quercetin-3-O-glucuronide (Q3GA), a phase II ...
Akari Ishisaka, Kyuichi Kawabata, Satomi Miki, Yuko Shiba, Shoko Minekawa, Tomomi Nishikawa, Rie Mukai, Junji Terao, Yoshichika Kawai   +8 more
doaj   +1 more source

Occurrence of bile alcohol glucuronides in bile of patients with cerebrotendinous xanthomatosis

Journal of Lipid Research, 1980
Using thin-layer chromatography, bile alcohol glucuronides were found with taurine- and glycine-conjugated bile acids in the bile of four patients with cerebrotendinous xanthomatosis.
T Hoshita, M Yasuhara, M Une, A Kibe, E Itoga, S Kito, T Kuramoto   +6 more
doaj   +1 more source

Phenelzine and Amoxapine Inhibit Tyramine and d-Glucuronic Acid Catabolism in Clinically Significant Salmonella in A Serotype-Independent Manner

Pathogens, 2021
Non-typhoidal Salmonella ingeniously scavenges energy for growth from tyramine (TYR) and d-glucuronic acid (DGA), both of which occur in the host as the metabolic byproducts of the gut microbial metabolism. A critical first step in energy scavenging from
Raquel Burin, Devendra H. Shah
doaj   +1 more source

The Effects of Flavonol and Flavone Glucuronides from Potentilla chinensis Leaves on TNF-α-Exposed Normal Human Dermal Fibroblasts

Antioxidants, 2023
Skin aging is a complex biological process influenced by a variety of factors, including UV radiation. UV radiation accelerates collagen degradation via the production of reactive oxygen species (ROS) and cytokines, including TNF-α.
Yea Jung Choi, So Young Lee, So-Ri Son, Jun Yeon Park, Dae Sik Jang, Sullim Lee   +5 more
doaj   +1 more source

Mechanism of the efflux transport of demethoxycurcumin-O-glucuronides in HeLa cells stably transfected with UDP-glucuronosyltransferase 1A1.

PLoS ONE, 2019
Demethoxycurcumin (DMC) is a safe and natural food-coloring additive, as well as an agent with several therapeutic properties. However, extensive glucuronidation in vivo has resulted in its poor bioavailability. In this study, we aimed to investigate the
Beibei Zhang, Jing Yang, Zifei Qin, Shishi Li, Jinjin Xu, Zhihong Yao, Xiaojian Zhang, Frank J Gonzalez, Xinsheng Yao   +8 more
doaj   +1 more source