Results 31 to 40 of about 33,429 (298)

Defective biliary secretion of bile acid 3-O-glucuronides in rats with hereditary conjugated hyperbilirubinemia.

Journal of Lipid Research, 1989
Biliary secretion of bile acid glucuronides was studied in control rats and in rats with a congenital defect in hepatobiliary transport of organic anions (GY rats).
F Kuipers, A Radominska, P Zimniak, J M Little, R Havinga, R J Vonk, R Lester   +6 more
doaj   +1 more source

In Vitro Metabolic Fate of the Synthetic Cannabinoid Receptor Agonists QMPSB and QMPCB (SGT-11) Including Isozyme Mapping and Esterase Activity

Metabolites, 2021
Quinolin-8-yl 4-methyl-3-(piperidine-1-sulfonyl)benzoate (QMPSB) and quinolin-8-yl 4-methyl-3-(piperidine-1-carbonyl)benzoate (QMPCB, SGT-11) are synthetic cannabinoid receptor agonists (SCRAs).
Matthias J. Richter, Lea Wagmann, Tanja M. Gampfer, Simon D. Brandt, Markus R. Meyer   +4 more
doaj   +1 more source

Disposition of Flavonoids via Recycling: Direct Biliary Excretion of Enterically or Extrahepatically Derived Flavonoid Glucuronides

Molecular Nutrition & Food Research, 2016
Scope Enterohepatic recycling is often thought to involve mostly phase II metabolites generated in the liver. This study aims to determine if direct biliary excretion of extrahepatically generated glucuronides would also enable recycling.
Min Zeng, Rongjin Sun, S. Basu, Yong Ma, Shufan Ge, Taijun Yin, Song Gao, Jun Zhang, Ming Hu   +8 more
semanticscholar   +1 more source

The Efflux Mechanism of Fraxetin-O-Glucuronides in UGT1A9-Transfected HeLa Cells: Identification of Multidrug Resistance-Associated Proteins 3 and 4 (MRP3/4) as the Important Contributors

Frontiers in Pharmacology, 2019
Fraxetin, a natural compound present in many dietary supplements and herbs, is useful in the treatment of acute bacillary dysentery and type 2 diabetes. Previously, several metabolic studies have revealed extensive first-pass metabolism causing formation
Zifei Qin, Zifei Qin, Beibei Zhang, Beibei Zhang, Jing Yang, Jing Yang, Shishi Li, Jinjin Xu, Zhihong Yao, Zhihong Yao, Xiaojian Zhang, Xiaojian Zhang, Frank J. Gonzalez, Xinsheng Yao, Xinsheng Yao   +14 more
doaj   +1 more source

APPROACHES TO THE DEVELOPMENT OF BIOANALYTICAL METHODS FOR DETERMINATION OF UNSTABLE SUBSTANCES IN BIOLOGICAL FLUIDS

Acta Biomedica Scientifica, 2018
The approaches to bioanalytical method development for determination of substances which contain unstable functional groups in the structure are described.
A. L. Khokhlov, I. I. Yaichkov, Yu. A. Dzhurko, M. Ryska, V. Kubeš, L. N. Shitov   +5 more
doaj   +1 more source

Deconjugation of soy isoflavone glucuronides needed for estrogenic activity.

Toxicology in Vitro, 2015
Soy isoflavones (SIF) are present in the systemic circulation as conjugated forms of which the estrogenic potency is not yet clear. The present study provides evidence that the major SIF glucuronide metabolites in blood, genistein-7-O-glucuronide (GG ...
M. A. Islam, R. Bekele, J. H. J. Vanden Berg, Y. Kuswanti, O. Thapa, S. Soltani, F. V. van Leeuwen, I. Rietjens, A. Murk   +8 more
semanticscholar   +1 more source

In Vitro and In Vivo Analysis of Ochratoxin A-Derived Glucuronides and Mercapturic Acids as Biomarkers of Exposure

Toxins, 2021
Ochratoxin A (OTA) is a widespread food contaminant, with exposure estimated to range from 0.64 to 17.79 ng/kg body weight (bw) for average consumers and from 2.40 to 51.69 ng/kg bw per day for high consumers.
Raphael Dekant, Michael Langer, Maria Lupp, Cynthia Adaku Chilaka, Angela Mally   +4 more
doaj   +1 more source

The UDP-glucuronosyltransferases of the blood-brain barrier: their role in drug metabolism and detoxication

Frontiers in Cellular Neuroscience, 2014
UDP-glucuronosyltransferases (UGTs) form a multigenic family of membrane-bound enzymes expressed in various tissues, including brain. They catalyze the formation of β-Dglucuronides from structurally unrelated substances (drugs, other xenobiotics, as well
Mohamed eOuzzine, Sandrine eGulberti, Nick eRamalanjaona, Jacques eMagdalou, Sylvie eFournel-Gigleux   +4 more
doaj   +1 more source

Metabolism of 2,3-Dehydrosilybin A and 2,3-Dehydrosilybin B: A Study with Human Hepatocytes and Recombinant UDP-Glucuronosyltransferases and Sulfotransferases

Antioxidants, 2021
2,3-Dehydrosilybin A and 2,3-dehydrosilybin B are a pair of enantiomers formed by the oxidation of the natural flavonolignans silybin A and silybin B, respectively.
Jiří Vrba, Barbora Papoušková, Kateřina Lněničková, Pavel Kosina, Vladimír Křen, Jitka Ulrichová   +5 more
doaj   +1 more source

Phase II Metabolism of Asarone Isomers In Vitro and in Humans Using HPLC-MS/MS and HPLC-qToF/MS

Foods, 2021
(1) Background: Metabolism data of asarone isomers, in particular phase II, in vitro and in humans is limited so far. For the first time, phase II metabolites of asarone isomers were characterized and human kinetic as well as excretion data after oral ...
Lena Hermes, Janis Römermann, Benedikt Cramer, Melanie Esselen   +3 more
doaj   +1 more source