Results 31 to 40 of about 41,898 (332)

Glucuronidation: driving factors and their impact on glucuronide disposition

Drug Metabolism Reviews, 2017
Glucuronidation is a well-recognized phase II metabolic pathway for a variety of chemicals including drugs and endogenous substances. Although it is usually the secondary metabolic pathway for a compound preceded by phase I hydroxylation, glucuronidation alone could serve as the dominant metabolic pathway for many compounds, including some with high ...
Guangyi, Yang, Shufan, Ge, Rashim, Singh, Sumit, Basu, Katherine, Shatzer, Ming, Zen, Jiong, Liu, Yifan, Tu, Chenning, Zhang, Jinbao, Wei, Jian, Shi, Lijun, Zhu, Zhongqiu, Liu, Yuan, Wang, Song, Gao, Ming, Hu   +15 more
openaire   +3 more sources

Development and Evaluation of Topical Formulation Containing Agrimonia pilosa Extract

Applied Sciences, 2023
Natural products are promising drug candidates with various pharmacological effects. However, they can be difficult to use due to poor bioavailability or low stability.
Jin Seok Lee, Yu Ran Nam, Su Jin Park, Ji Min Lee, Hyun Jong Kim, Woo Kyung Kim   +5 more
doaj   +1 more source

Glucuronides of phytoestrogen flavonoid enhance macrophage function via conversion to aglycones by β‐glucuronidase in macrophages

Immunity, Inflammation and Disease, 2017
Flavonoids are converted to inactive metabolites like glucuronides in the gut, and circulate mainly as glucuronides in blood stream, resulting in low concentrations of active aglycones in plasma.
A. Kaneko, Takashi Matsumoto, Yosuke Matsubara, K. Sekiguchi, J. Koseki, R. Yakabe, Katsuyuki Aoki, S. Aiba, K. Yamasaki   +8 more
semanticscholar   +1 more source

Phenolic metabolites of anthocyanins following a dietary intervention study in post-menopausal women [PDF]

, 2014
Scope Numerous studies feeding anthocyanin-rich foods report limited bioavailability of the parent anthocyanins. The present study explores the identity and concentration of the phenolic metabolites of anthocyanins in humans.
Aura, Azzini, Berg, Bitsch, Cao, Cassidy, Cassidy, Curtis, Czank, Del Rio, Dykes, Edirisinghe, Egert, Felgines, Fossen, Garcia-Alonso, Gonzalez-Barrio, Griffiths, Hollman, Kay, Kay, Kay, Koli, Manach, Milbury, Mink, Mullen, Murkovic, Mülleder, Nurmi, Russell, Schmitzer, Selma, Toromanović, Valentova, Veberic, Vitaglione, Weber, Williamson, Williamson, Winter, Wu, Xu, Zhang, Zhang   +44 more
core   +1 more source

Regular, low-dose methadone for reducing breathlessness in people experiencing or at risk of neurotoxic effects from morphine: A single-center case series

Frontiers in Medicine, 2022
Breathlessness is a common symptom suffered by people living with advanced malignant and non-malignant diseases, one which significantly limits their quality of life.
Piotr Z. Sobanski, David C. Currow
doaj   +1 more source

The role of mycotoxins in the human exposome: Application of mycotoxin biomarkers in exposome-health studies [PDF]

, 2018
Mycotoxins are secondary metabolites produced by fungi that may contaminate different foods intended for human consumption, resulting in a widespread exposure worldwide. The novel exposome paradigm has the ambition to decipher the different environmental
Cano Sancho, German, Marín Sillué, Sònia, Ramos Girona, Antonio J., Sanchís Almenar, Vicente   +3 more
core   +4 more sources

Plasma Pharmacokinetics of Polyphenols in a Traditional Japanese Medicine, Jumihaidokuto, Which Suppresses Propionibacterium acnes-Induced Dermatitis in Rats

Molecules, 2015
Most orally administered polyphenols are metabolized, with very little absorbed as aglycones and/or unchanged forms. Metabolic and pharmacokinetic studies are therefore necessary to understand the pharmacological mechanisms of polyphenols. Jumihaidokuto (
Takashi Matsumoto, Yousuke Matsubara, Yasuharu Mizuhara, Kyoji Sekiguchi, Junichi Koseki, Kazuaki Tsuchiya, Hiroaki Nishimura, Junko Watanabe, Atsushi Kaneko, Kazuya Maemura, Tomohisa Hattori, Yoshio Kase   +11 more
doaj   +1 more source

Resveratrol given intraperitoneally does not inhibit the growth of high-risk t(4;11) acute lymphoblastic leukemia cells in a NOD/SCID mouse model. [PDF]

, 2011
The efficacy of resveratrol as a preventive agent against the growth of t(4;11) acute lymphoblastic leukemia (ALL) was evaluated in NOD.CB17-Prkdcscid/J mice engrafted with the human t(4;11) ALL SEM cell line.
Ducore, Jonathan M, Keen, Carl L, Newman, John W, Pedersen, Theresa L, Storms, David H, Zunino, Susan J   +5 more
core   +1 more source

Exploring the Metabolism of (+)-[18F]Flubatine In Vitro and In Vivo: LC-MS/MS Aided Identification of Radiometabolites in a Clinical PET Study †

Molecules, 2018
Both (+)-[18F]flubatine and its enantiomer (−)-[18F]flubatine are radioligands for the neuroimaging of α4β2 nicotinic acetylcholine receptors (nAChRs) by positron emission tomography (PET). In a clinical study in patients with early Alzheimer’s disease, (
Friedrich-Alexander Ludwig, Steffen Fischer, René Smits, Winnie Deuther-Conrad, Alexander Hoepping, Solveig Tiepolt, Marianne Patt, Osama Sabri, Peter Brust   +8 more
doaj   +1 more source

In Vitro Metabolic Fate of the Synthetic Cannabinoid Receptor Agonists QMPSB and QMPCB (SGT-11) Including Isozyme Mapping and Esterase Activity

Metabolites, 2021
Quinolin-8-yl 4-methyl-3-(piperidine-1-sulfonyl)benzoate (QMPSB) and quinolin-8-yl 4-methyl-3-(piperidine-1-carbonyl)benzoate (QMPCB, SGT-11) are synthetic cannabinoid receptor agonists (SCRAs).
Matthias J. Richter, Lea Wagmann, Tanja M. Gampfer, Simon D. Brandt, Markus R. Meyer   +4 more
doaj   +1 more source