Results 21 to 30 of about 33,429 (298)

Glucuronidation of deoxynivalenol (DON) by different animal species: identification of iso-DON glucuronides and iso-deepoxy-DON glucuronides as novel DON metabolites in pigs, rats, mice, and cows

Archives of Toxicology, 2017
The Fusarium mycotoxin deoxynivalenol (DON) is a frequent contaminant of cereal-based food and feed. Mammals metabolize DON by conjugation to glucuronic acid (GlcAc), the extent and regioselectivity of which is species-dependent.
H. Schwartz-Zimmermann, C. Hametner, V. Nagl, Iris Fiby, Lukas Macheiner, J. Winkler, S. Dänicke, Erica S. Clark, J. Pestka, F. Berthiller   +9 more
semanticscholar   +1 more source

Mechanism of the efflux transport of demethoxycurcumin-O-glucuronides in HeLa cells stably transfected with UDP-glucuronosyltransferase 1A1.

PLoS ONE, 2019
Demethoxycurcumin (DMC) is a safe and natural food-coloring additive, as well as an agent with several therapeutic properties. However, extensive glucuronidation in vivo has resulted in its poor bioavailability. In this study, we aimed to investigate the
Beibei Zhang, Jing Yang, Zifei Qin, Shishi Li, Jinjin Xu, Zhihong Yao, Xiaojian Zhang, Frank J Gonzalez, Xinsheng Yao   +8 more
doaj   +1 more source

Glucuronidation: driving factors and their impact on glucuronide disposition

Drug Metabolism Reviews, 2017
Glucuronidation is a well-recognized phase II metabolic pathway for a variety of chemicals including drugs and endogenous substances. Although it is usually the secondary metabolic pathway for a compound preceded by phase I hydroxylation, glucuronidation alone could serve as the dominant metabolic pathway for many compounds, including some with high ...
Guangyi, Yang, Shufan, Ge, Rashim, Singh, Sumit, Basu, Katherine, Shatzer, Ming, Zen, Jiong, Liu, Yifan, Tu, Chenning, Zhang, Jinbao, Wei, Jian, Shi, Lijun, Zhu, Zhongqiu, Liu, Yuan, Wang, Song, Gao, Ming, Hu   +15 more
openaire   +3 more sources

The Effects of Flavonol and Flavone Glucuronides from Potentilla chinensis Leaves on TNF-α-Exposed Normal Human Dermal Fibroblasts

Antioxidants, 2023
Skin aging is a complex biological process influenced by a variety of factors, including UV radiation. UV radiation accelerates collagen degradation via the production of reactive oxygen species (ROS) and cytokines, including TNF-α.
Yea Jung Choi, So Young Lee, So-Ri Son, Jun Yeon Park, Dae Sik Jang, Sullim Lee   +5 more
doaj   +1 more source

Glucuronides of phytoestrogen flavonoid enhance macrophage function via conversion to aglycones by β‐glucuronidase in macrophages

Immunity, Inflammation and Disease, 2017
Flavonoids are converted to inactive metabolites like glucuronides in the gut, and circulate mainly as glucuronides in blood stream, resulting in low concentrations of active aglycones in plasma.
A. Kaneko, Takashi Matsumoto, Yosuke Matsubara, K. Sekiguchi, J. Koseki, R. Yakabe, Katsuyuki Aoki, S. Aiba, K. Yamasaki   +8 more
semanticscholar   +1 more source

Multiomics Approach Captures Hepatic Metabolic Network Altered by Chronic Ethanol Administration

Biology, 2022
Using a multiplatform and multiomics approach, we identified metabolites, lipids, proteins, and metabolic pathways that were altered in the liver after chronic ethanol administration.
Isin Tuna Sakallioglu, Bridget Tripp, Jacy Kubik, Carol A. Casey, Paul Thomes, Robert Powers   +5 more
doaj   +1 more source

Development and Evaluation of Topical Formulation Containing Agrimonia pilosa Extract

Applied Sciences, 2023
Natural products are promising drug candidates with various pharmacological effects. However, they can be difficult to use due to poor bioavailability or low stability.
Jin Seok Lee, Yu Ran Nam, Su Jin Park, Ji Min Lee, Hyun Jong Kim, Woo Kyung Kim   +5 more
doaj   +1 more source

Plasma Pharmacokinetics of Polyphenols in a Traditional Japanese Medicine, Jumihaidokuto, Which Suppresses Propionibacterium acnes-Induced Dermatitis in Rats

Molecules, 2015
Most orally administered polyphenols are metabolized, with very little absorbed as aglycones and/or unchanged forms. Metabolic and pharmacokinetic studies are therefore necessary to understand the pharmacological mechanisms of polyphenols. Jumihaidokuto (
Takashi Matsumoto, Yousuke Matsubara, Yasuharu Mizuhara, Kyoji Sekiguchi, Junichi Koseki, Kazuaki Tsuchiya, Hiroaki Nishimura, Junko Watanabe, Atsushi Kaneko, Kazuya Maemura, Tomohisa Hattori, Yoshio Kase   +11 more
doaj   +1 more source

Regular, low-dose methadone for reducing breathlessness in people experiencing or at risk of neurotoxic effects from morphine: A single-center case series

Frontiers in Medicine, 2022
Breathlessness is a common symptom suffered by people living with advanced malignant and non-malignant diseases, one which significantly limits their quality of life.
Piotr Z. Sobanski, David C. Currow
doaj   +1 more source

Exploring the Metabolism of (+)-[18F]Flubatine In Vitro and In Vivo: LC-MS/MS Aided Identification of Radiometabolites in a Clinical PET Study †

Molecules, 2018
Both (+)-[18F]flubatine and its enantiomer (−)-[18F]flubatine are radioligands for the neuroimaging of α4β2 nicotinic acetylcholine receptors (nAChRs) by positron emission tomography (PET). In a clinical study in patients with early Alzheimer’s disease, (
Friedrich-Alexander Ludwig, Steffen Fischer, René Smits, Winnie Deuther-Conrad, Alexander Hoepping, Solveig Tiepolt, Marianne Patt, Osama Sabri, Peter Brust   +8 more
doaj   +1 more source