Results 21 to 30 of about 41,898 (332)

Synthetic β‑d‑Glucuronides: Substrates for Exploring Glucuronide Degradation by Human Gut Bacteria [PDF]

ACS Omega
Aleksandra Gorecka, Heidi Schacht, Megan K. Fraser, Aleksandra Teriosina, James A. London, Igor L. Barsukov, Andrew K. Powell, Alan Cartmell, Andrew V. Stachulski, Edwin A. Yates   +9 more
doaj   +2 more sources

Human UDP-glucuronosyltransferase UGT1A4 forms tertiary N-glucuronides predominately with the energetically less favored tautomer of substituted 1H-indazole (benzpyrazole)

Journal of Analytical Science and Technology, 2017
Background Human UDP-glucuronosyltransferase UGT1A4 is reported to convert a range of tertiary amine substrates to the respective quaternary glucuronides. In this study, we report on the in vitro glucuronidation of a substituted 1H-indazole (benzpyrazole)
Andreas Fredenhagen, Fabian K. Eggimann, Matthias Kittelmann, Thomas Lochmann, Jürgen Kühnöl   +4 more
doaj   +1 more source

Involvement of UDP-Glucuronosyltransferases and Sulfotransferases in the Excretion and Tissue Distribution of Resveratrol in Mice. [PDF]

, 2017
Resveratrol is a naturally occurring polyphenolic compound with various pharmacological activities. It is unknown whether the expression of metabolizing enzymes correlates with resveratrol levels in organs and tissues.
Brenner, Stefan, Böhmdorfer, Michaela, Jäger, Walter, Riha, Juliane, Schiestl, Robert H, Szakmary, Akos, Szekeres, Thomas, Thalhammer, Theresia, Vaquero, Javier   +8 more
core   +2 more sources

Occurrence of bile alcohol glucuronides in bile of patients with cerebrotendinous xanthomatosis

Journal of Lipid Research, 1980
Using thin-layer chromatography, bile alcohol glucuronides were found with taurine- and glycine-conjugated bile acids in the bile of four patients with cerebrotendinous xanthomatosis.
T Hoshita, M Yasuhara, M Une, A Kibe, E Itoga, S Kito, T Kuramoto   +6 more
doaj   +1 more source

Phenelzine and Amoxapine Inhibit Tyramine and d-Glucuronic Acid Catabolism in Clinically Significant Salmonella in A Serotype-Independent Manner

Pathogens, 2021
Non-typhoidal Salmonella ingeniously scavenges energy for growth from tyramine (TYR) and d-glucuronic acid (DGA), both of which occur in the host as the metabolic byproducts of the gut microbial metabolism. A critical first step in energy scavenging from
Raquel Burin, Devendra H. Shah
doaj   +1 more source

Postmortem tissue distribution of morphine and its metabolites in a series of heroin related deaths [PDF]

, 2018
The abuse of heroin (diamorphine) and heroin deaths are growing around the world. The interpretation of the toxicological results from suspected heroin deaths is notoriously difficult especially in cases where there may be limited samples.
Beer, Lewis J., Crichton, Megan L., De Paoli, Giorgia, Drummond, Gail, Maskell, Peter D., Seetohul, L. Nitin, Wilson, Nathan E.   +6 more
core   +5 more sources

The Effects of Flavonol and Flavone Glucuronides from Potentilla chinensis Leaves on TNF-α-Exposed Normal Human Dermal Fibroblasts

Antioxidants, 2023
Skin aging is a complex biological process influenced by a variety of factors, including UV radiation. UV radiation accelerates collagen degradation via the production of reactive oxygen species (ROS) and cytokines, including TNF-α.
Yea Jung Choi, So Young Lee, So-Ri Son, Jun Yeon Park, Dae Sik Jang, Sullim Lee   +5 more
doaj   +1 more source

Glucuronidation of deoxynivalenol (DON) by different animal species: identification of iso-DON glucuronides and iso-deepoxy-DON glucuronides as novel DON metabolites in pigs, rats, mice, and cows

Archives of Toxicology, 2017
The Fusarium mycotoxin deoxynivalenol (DON) is a frequent contaminant of cereal-based food and feed. Mammals metabolize DON by conjugation to glucuronic acid (GlcAc), the extent and regioselectivity of which is species-dependent.
H. Schwartz-Zimmermann, C. Hametner, V. Nagl, Iris Fiby, Lukas Macheiner, J. Winkler, S. Dänicke, Erica S. Clark, J. Pestka, F. Berthiller   +9 more
semanticscholar   +1 more source

Mechanism of the efflux transport of demethoxycurcumin-O-glucuronides in HeLa cells stably transfected with UDP-glucuronosyltransferase 1A1.

PLoS ONE, 2019
Demethoxycurcumin (DMC) is a safe and natural food-coloring additive, as well as an agent with several therapeutic properties. However, extensive glucuronidation in vivo has resulted in its poor bioavailability. In this study, we aimed to investigate the
Beibei Zhang, Jing Yang, Zifei Qin, Shishi Li, Jinjin Xu, Zhihong Yao, Xiaojian Zhang, Frank J Gonzalez, Xinsheng Yao   +8 more
doaj   +1 more source

Multiomics Approach Captures Hepatic Metabolic Network Altered by Chronic Ethanol Administration

Biology, 2022
Using a multiplatform and multiomics approach, we identified metabolites, lipids, proteins, and metabolic pathways that were altered in the liver after chronic ethanol administration.
Isin Tuna Sakallioglu, Bridget Tripp, Jacy Kubik, Carol A. Casey, Paul Thomes, Robert Powers   +5 more
doaj   +1 more source