Results 11 to 20 of about 41,898 (332)
Mitochondrial dysfunction leads to deconjugation of quercetin glucuronides in inflammatory macrophages. [PDF]
PLoS ONE, 2013 Dietary flavonoids, such as quercetin, have long been recognized to protect blood vessels from atherogenic inflammation by yet unknown mechanisms. We have previously discovered the specific localization of quercetin-3-O-glucuronide (Q3GA), a phase II ...
Akari Ishisaka +8 more
doaj +2 more sources
Biomonitoring of Deoxynivalenol and Deoxynivalenol-3-glucoside in Human Volunteers: Renal Excretion Profiles [PDF]
Toxins, 2019 Biomarkers for the determination of the dietary exposure to deoxynivalenol (DON) have been proposed in the past but so far no quantification of their use in humans has been carried out. Following a human intervention study with two mycotoxins, namely DON
Marcel Mengelers +5 more
doaj +3 more sources
Antioxidants, 2015 Curcumin metabolites namely curcumin monoglucuronide and curcumin diglucuronide were synthesized using an alternative synthetic approach. The anti-oxidant potential of these curcumin glucuronides was compared with that of curcumin using DPPH scavenging ...
Ambar K. Choudhury +4 more
doaj +2 more sources
Investigation of urinary steroid metabolites in calf urine after oral and intramuscular administration of DHEA [PDF]
, 2010 DHEA (3 beta-hydroxy-androst-5-en-17-one) is a natural steroid prohormone. Despite a lack of information on the effect, DHEA and other prohormones are frequently used as a food supplement by body-builders.
Becue, Ilse +5 more
core +5 more sources
Hepatology Communications, 2021 Accumulation of cytotoxic bile acids (BAs) during cholestasis can result in liver failure. Glucuronidation, a phase II metabolism pathway responsible for BA detoxification, is regulated by peroxisome proliferator–activated receptor alpha (PPARα).
Gina M. Gallucci +6 more
doaj +1 more source
Tethered Indoxyl-Glucuronides for Enzymatically Triggered Cross-Linking
Molecules, 2023 Indoxyl-glucuronides, upon treatment with β-glucuronidase under physiological conditions, are well known to afford the corresponding indigoid dye via oxidative dimerization.
Juno Son +6 more
doaj +1 more source
Glucuronides in the gut: Sugar-driven symbioses between microbe and host
Journal of Biological Chemistry, 2017 The intestinal milieu is astonishingly complex and home to a constantly changing mixture of small and large molecules, along with an abundance of bacteria, viral particles, and eukaryotic cells.
S. Pellock, M. Redinbo
semanticscholar +1 more source
Separations, 2022 Calycosin is a dietary flavonoid with favorable activities, which seems to be inconsistent with its low circulating levels in vivo. To address this issue, we developed a strategy to understand calycosin distribution by integrating qualitative and ...
Haodong Jiang +6 more
doaj +1 more source
Impact of glucuronide interferences on therapeutic drug monitoring of posaconazole by tandem mass spectrometry [PDF]
, 2010 Background: Posaconazole is a novel antifungal drug for oral application intended especially for therapy of invasive mycoses. Due to variable gastrointestinal absorption, adverse side effects, and suspected drug-drug interactions, therapeutic drug ...
Burghardt, Stephan +4 more
core +1 more source
Deconjugation Kinetics of Glucuronidated Phase II Flavonoid Metabolites by B-glucuronidase from Neutrophils [PDF]
, 2010 Flavonoids are inactivated by phase II metabolism and occur in the body as glucuronides. Mammalian ß-glucuronidase released from neutrophils at inflammatory sites may be able to deconjugate and thus activate flavonoid glucuronides.
Arts, I.C.W. +9 more
core +2 more sources