Results 41 to 50 of about 41,898 (332)

Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain [PDF]

, 2010
The consumption of flavonoid-rich foods and beverages has been suggested to limit the neurodegeneration associated with a variety of neurological disorders and to prevent or reverse normal or abnormal deteriorations in cognitive performance.
Spencer, Jeremy Paul
core   +1 more source

Defective biliary secretion of bile acid 3-O-glucuronides in rats with hereditary conjugated hyperbilirubinemia.

Journal of Lipid Research, 1989
Biliary secretion of bile acid glucuronides was studied in control rats and in rats with a congenital defect in hepatobiliary transport of organic anions (GY rats).
F Kuipers, A Radominska, P Zimniak, J M Little, R Havinga, R J Vonk, R Lester   +6 more
doaj   +1 more source

Disposition of Flavonoids via Recycling: Direct Biliary Excretion of Enterically or Extrahepatically Derived Flavonoid Glucuronides

Molecular Nutrition & Food Research, 2016
Scope Enterohepatic recycling is often thought to involve mostly phase II metabolites generated in the liver. This study aims to determine if direct biliary excretion of extrahepatically generated glucuronides would also enable recycling.
Min Zeng, Rongjin Sun, S. Basu, Yong Ma, Shufan Ge, Taijun Yin, Song Gao, Jun Zhang, Ming Hu   +8 more
semanticscholar   +1 more source

Non-targeted LC-MS based metabolomics analysis of the urinary steroidal profile [PDF]

, 2017
The urinary steroidal fraction has been extensively explored as non-invasive alternative to monitor pathological conditions as well as to unveil the illicit intake of pseudo-endogenous anabolic steroids in sport.
Botrè, Francesco, de la Torre, Xavier, Palermo, Amelia, Zamboni, Nicola   +3 more
core   +1 more source

The Efflux Mechanism of Fraxetin-O-Glucuronides in UGT1A9-Transfected HeLa Cells: Identification of Multidrug Resistance-Associated Proteins 3 and 4 (MRP3/4) as the Important Contributors

Frontiers in Pharmacology, 2019
Fraxetin, a natural compound present in many dietary supplements and herbs, is useful in the treatment of acute bacillary dysentery and type 2 diabetes. Previously, several metabolic studies have revealed extensive first-pass metabolism causing formation
Zifei Qin, Zifei Qin, Beibei Zhang, Beibei Zhang, Jing Yang, Jing Yang, Shishi Li, Jinjin Xu, Zhihong Yao, Zhihong Yao, Xiaojian Zhang, Xiaojian Zhang, Frank J. Gonzalez, Xinsheng Yao, Xinsheng Yao   +14 more
doaj   +1 more source

Simultaneous determination of natural and synthetic steroid estrogens and their conjugates in aqueous matrices by liquid chromatography / mass spectrometry [PDF]

, 2005
An analytical method for the simultaneous determination of nine free and conjugated steroid estrogens was developed with application to environmental aqueous matrices.
Bean KA, Belfroid AC, Berg FD, Bowers LD, Bowers Sanaullah LD, Choi BK, Croley TR, Desbrow C, Diaz-Cruz MS, Dray J, D’Ascenzo G, Fotsis T, Fotsis T, Gangl ET, Gentilli A, Gomes RL, Gomes RL, Gomes RL, Hogenboom AC, Huang C-H, Huang C-H, Isobe T, Ito S, Jason W. Birkett, John N. Lester, Kanda R, King R, Kuch HM, Liang HR, Mallet CR, Mark D. Scrimshaw, Mouatassim–Souali A, Rachel L. Gomes, Ranney RE, Rodgers–Gray TP, Snyder SA, Steen R, Steimer T, Tabak HH, Tang PW, Ternes TA, Ternes TA, Thomas KV, Zhang H   +43 more
core   +1 more source

Recent Trends in Metabolomics by NMR Spectroscopy

Angewandte Chemie, EarlyView.
AI tools were applied to analyze more than 5 000 publications indexed in Scopus (2018–2025), identifying key trends and research directions in NMR‐based metabolomics. The artificial intelligence‐assisted workflow classified papers into six main fields of application, human health, food and nutrition, veterinary science, plants, environment, and ...
Giorgio Di Paco, Gaia Meoni, Veronica Ghini, Alessia Vignoli, Leonardo Tenori, Paola Turano, Claudio Luchinat   +6 more
wiley   +2 more sources

APPROACHES TO THE DEVELOPMENT OF BIOANALYTICAL METHODS FOR DETERMINATION OF UNSTABLE SUBSTANCES IN BIOLOGICAL FLUIDS

Acta Biomedica Scientifica, 2018
The approaches to bioanalytical method development for determination of substances which contain unstable functional groups in the structure are described.
A. L. Khokhlov, I. I. Yaichkov, Yu. A. Dzhurko, M. Ryska, V. Kubeš, L. N. Shitov   +5 more
doaj   +1 more source

In Vitro and In Vivo Analysis of Ochratoxin A-Derived Glucuronides and Mercapturic Acids as Biomarkers of Exposure

Toxins, 2021
Ochratoxin A (OTA) is a widespread food contaminant, with exposure estimated to range from 0.64 to 17.79 ng/kg body weight (bw) for average consumers and from 2.40 to 51.69 ng/kg bw per day for high consumers.
Raphael Dekant, Michael Langer, Maria Lupp, Cynthia Adaku Chilaka, Angela Mally   +4 more
doaj   +1 more source

Deconjugation of soy isoflavone glucuronides needed for estrogenic activity.

Toxicology in Vitro, 2015
Soy isoflavones (SIF) are present in the systemic circulation as conjugated forms of which the estrogenic potency is not yet clear. The present study provides evidence that the major SIF glucuronide metabolites in blood, genistein-7-O-glucuronide (GG ...
M. A. Islam, R. Bekele, J. H. J. Vanden Berg, Y. Kuswanti, O. Thapa, S. Soltani, F. V. van Leeuwen, I. Rietjens, A. Murk   +8 more
semanticscholar   +1 more source