Results 261 to 270 of about 41,898 (332)
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MicrosomalAcyl Glucuronidation: Enzyme-Kinetic Studies with Labile Glucuronides
Pharmacology, 1993Because of the labile nature of acyl glucuronides under physiologic conditions, metabolic rates of formation calculated using traditional methods may be confounded by concomitant rates of degradation. True metabolic formation rates may be approximated by stabilization of the metabolic product or by purifying the metabolite and calculating its ...
H, Spahn-Langguth, L Z, Benet
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Drug glucuronidation in humans
Pharmacology & Therapeutics, 1991Glucuronidation is a major metabolic pathway for a large number of drugs in humans. Conjugation of drugs and other chemicals with glucuronic acid is catalyzed by the multigene UDP-glucuronosyltransferase family. It is believed that a number (unspecified at present) of glucuronosyltransferase isozymes, which probably differ in terms of substrate ...
J O, Miners, P I, Mackenzie
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Acta Pharmacologica et Toxicologica, 1978
Abstract Uptake studies, using radioactive labelled glucuronides, have demonstrated the ability of 4‐nitrophenyl glucuronide and phenolphthalein glucuronide to enter isolated rat hepatocytes. Of these glucuronides 4‐nitrophenyl glucuronide was distributed in a similar manner to O‐methylglucose, whereas phenolphthalein glucuronide was bound to cellular ...
A, Norling +3 more
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Abstract Uptake studies, using radioactive labelled glucuronides, have demonstrated the ability of 4‐nitrophenyl glucuronide and phenolphthalein glucuronide to enter isolated rat hepatocytes. Of these glucuronides 4‐nitrophenyl glucuronide was distributed in a similar manner to O‐methylglucose, whereas phenolphthalein glucuronide was bound to cellular ...
A, Norling +3 more
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The Effect of Chloroform Inhalation on Hepatic Glucuronidation and De-Glucuronidation Mechanisms
Drug and Chemical Toxicology, 1980The effect of 2, 4, 6 or 8 exposures to chloroform vapour on hepatic glucuronidating (UDPGA transferase) and de-glucuronidating (beta-glucuronidase) levels has been studied in rats. Successive treatments progressively decreased hepatic UDPGA transferase to a minimum of 53% of the control level.
I D, Capel +3 more
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Scintigraphic imaging with a peptide glucuronide in rabbits: 99mTc- exorphin C glucuronide
Applied Radiation and Isotopes, 2007A peptide glucuronide (Exorphin C glucuronide) was labeled with 99mTc using glucoheptonate (GH) as a bifunctional chelating agent. Scintigraphic imaging was performed in male Albino rabbits. Exorphin C glucuronide showed rapid and efficient labeling with 99mTc using glucoheptonate as a bifunctional chelate.
Ertay T. +5 more
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Morphine‐3‐glucuronide prevents tolerance to morphine‐6‐glucuronide in mice
European Journal of Pain, 1997Daily subcutaneous (s.c.) pretreatment with morphine‐3‐glucuronide (6 mg/kg) was found to reduce morphine‐6‐glucuronide (4 mg/kg s.c.)‐induced antinociception, with no decrease in the effect over 5 days. Morphine‐6‐glucuronide administration (4 mg/kg s.c.) on Day 6, without morphine‐3‐glucorinide pretreatment, results in a significant increase in ...
Faura, Clara C. +2 more
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The mechanism of glucuronide formation
Biochemical Pharmacology, 1961Abstract The mechanism of formation of simple glucuronides in animal tissues is reviewed. So far glucuronide synthesis has been found to occur in liver and to a lesser extent in kidney of a number of animal species. Of the mammals studied cat liver slices formed very little glucuronide. More recently glucuronide formation has been discovered to occur
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Clinical Pharmacokinetics, 1999
During human development impressive changes in drug disposition occur. An important determinant of drug clearance is metabolism, something that is not only determined by ontogenic regulation but also by genetic processes which add to the variability of drug metabolism during different stages of childhood.
de Wildt, Saskia +3 more
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During human development impressive changes in drug disposition occur. An important determinant of drug clearance is metabolism, something that is not only determined by ontogenic regulation but also by genetic processes which add to the variability of drug metabolism during different stages of childhood.
de Wildt, Saskia +3 more
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Biochemical pharmacology, 1991
Diflunisal (DF) is metabolized primarily to its acyl glucuronide (DAG), phenolic glucuronide (DPG) and sulphate (DS) conjugates. Whereas DPG and DS are stable at physiological pH, DAG is unstable, undergoing hydrolysis (regeneration of DF) and rearrangement (intramolecular acyl migration to the 2-, 3- and 4-O-acyl-positional isomers).
King A.R., Dickinson R.G.
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Diflunisal (DF) is metabolized primarily to its acyl glucuronide (DAG), phenolic glucuronide (DPG) and sulphate (DS) conjugates. Whereas DPG and DS are stable at physiological pH, DAG is unstable, undergoing hydrolysis (regeneration of DF) and rearrangement (intramolecular acyl migration to the 2-, 3- and 4-O-acyl-positional isomers).
King A.R., Dickinson R.G.
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