Results 241 to 250 of about 41,898 (332)

Morusin as a drug candidate: opportunities, limitations, and the path toward clinical translation. [PDF]

Front Pharmacol
Azzam HN, El-Dessouki AM, Attallah KA, Sadek MA, Aboulmagd YM, Hassan MM, Fahmy MI, El-Shiekh RA, Kamal RM, Khalifa HO.   +9 more
europepmc   +1 more source

Profile of steroid metabolites in human breast milk in different stages of lactation.

Food Funct
Khymenets O, Vilarroya O, Benet G, Feixas G, Arranz Betegon A, McLeod MD, Pozo OJ.   +6 more
europepmc   +1 more source

Rare Cholesterol Related Disorders – A Sterolomic Library for Diagnosis and Monitoring of Diseases

Griffiths WJ, Asgari MA, Yutuc E, Abdel-Khalik J, Crick PJ, Morris AA, Jones SA, Ghosh A, Hart C, Schöls L, Matysik S, Laina I, Pickrell WO, Moat SJ, Wang Y.   +14 more
europepmc   +1 more source

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Unusual Glucuronides

Drug Metabolism and Disposition, 2012
Glucuronidation reaction is catalyzed by mammalian uridine diphosphoglucuronosyl transferases by using uridine diphosphoglucuronic acid as a cosubstrate. Conjugation of glucuronic acid to nucleophilic functional groups in chemical entities results in formation of glucuronides. As anticipated, a number of nucleophilic functional groups such as hydroxyl,
U. Argikar
openaire   +3 more sources

Challenges and Recommendations in Developing LC–MS/MS Bioanalytical Assays of Labile Glucuronides and Parent Compounds in the Presence of Glucuronide Metabolites

Bioanalysis, 2020
Glucuronides, especially acyl glucuronides, were often found to be unstable in vitro and in vivo. Acyl glucuronide metabolites can convert back to the parent drugs at physiological pH through hydrolysis.
Long Yuan, Qin C Ji, Long Yuan
exaly   +2 more sources

Targeted LC-MS/MS analysis of steroid glucuronides in human urine.

Journal of Steroid Biochemistry and Molecular Biology, 2020
Conjugation with glucuronic acid is one of the major metabolic reactions in human steroid hormone catabolism. Recently, increasing interest has been raised concerning the biological roles of steroid glucuronides. We have therefore developed and validated
Rong Wang, M. Hartmann, S. Wudy
semanticscholar   +1 more source

NEW PERSPECTIVES ON DRUG-INDUCED LIVER INJURY RISK ASSESSMENT OF ACYL GLUCURONIDES.

Chemical Research in Toxicology, 2020
Drug-induced liver injury (DILI) remains one of the key challenges in drug development due to the mechanisms of action being multi-factorial in nature. This is particularly the case for idiosyncratic DILI which occurs in very low frequency in man (eg, 1 ...
M. Walles, Alan P. Brown, A. Zimmerlin, P. End   +3 more
semanticscholar   +1 more source

Antioxidant and anti-inflammatory flavonol glucuronides from Polygonum aviculare L.

Fìtoterapìâ, 2013
Sebastian Granica, Monika E Czerwińska, Barbara Żyżyńska-Granica   +2 more
exaly   +2 more sources