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Scintigraphic imaging with a peptide glucuronide in rabbits: 99mTc- exorphin C glucuronide
Applied Radiation and Isotopes, 2007A peptide glucuronide (Exorphin C glucuronide) was labeled with 99mTc using glucoheptonate (GH) as a bifunctional chelating agent. Scintigraphic imaging was performed in male Albino rabbits. Exorphin C glucuronide showed rapid and efficient labeling with 99mTc using glucoheptonate as a bifunctional chelate.
Ertay T. +5 more
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The mechanism of glucuronide formation
Biochemical Pharmacology, 1961Abstract The mechanism of formation of simple glucuronides in animal tissues is reviewed. So far glucuronide synthesis has been found to occur in liver and to a lesser extent in kidney of a number of animal species. Of the mammals studied cat liver slices formed very little glucuronide. More recently glucuronide formation has been discovered to occur
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Morphine‐3‐glucuronide prevents tolerance to morphine‐6‐glucuronide in mice
European Journal of Pain, 1997Daily subcutaneous (s.c.) pretreatment with morphine‐3‐glucuronide (6 mg/kg) was found to reduce morphine‐6‐glucuronide (4 mg/kg s.c.)‐induced antinociception, with no decrease in the effect over 5 days. Morphine‐6‐glucuronide administration (4 mg/kg s.c.) on Day 6, without morphine‐3‐glucorinide pretreatment, results in a significant increase in ...
Faura, Clara C. +2 more
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Clinical Pharmacokinetics, 1999
During human development impressive changes in drug disposition occur. An important determinant of drug clearance is metabolism, something that is not only determined by ontogenic regulation but also by genetic processes which add to the variability of drug metabolism during different stages of childhood.
de Wildt, Saskia +3 more
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During human development impressive changes in drug disposition occur. An important determinant of drug clearance is metabolism, something that is not only determined by ontogenic regulation but also by genetic processes which add to the variability of drug metabolism during different stages of childhood.
de Wildt, Saskia +3 more
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Biochemical pharmacology, 1991
Diflunisal (DF) is metabolized primarily to its acyl glucuronide (DAG), phenolic glucuronide (DPG) and sulphate (DS) conjugates. Whereas DPG and DS are stable at physiological pH, DAG is unstable, undergoing hydrolysis (regeneration of DF) and rearrangement (intramolecular acyl migration to the 2-, 3- and 4-O-acyl-positional isomers).
King A.R., Dickinson R.G.
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Diflunisal (DF) is metabolized primarily to its acyl glucuronide (DAG), phenolic glucuronide (DPG) and sulphate (DS) conjugates. Whereas DPG and DS are stable at physiological pH, DAG is unstable, undergoing hydrolysis (regeneration of DF) and rearrangement (intramolecular acyl migration to the 2-, 3- and 4-O-acyl-positional isomers).
King A.R., Dickinson R.G.
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Toxicological potential of acyl glucuronides and its assessment.
Drug Metabolism and Pharmacokinetics, 2017A. Iwamura +3 more
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The influence of physicochemical properties on the reactivity and stability of acyl glucuronides†
Xenobiotica; the fate of foreign compounds in biological systems, 2018P. Camilleri, A. Buch, B. Soldo, A. Hutt
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Two new flavonol-bis-3,7-glucuronides from Geum rivale L
Phytochemistry Letters, 2021Andrei Whaley, Maria Povydysh
exaly
19. EFFECT OF GLUCURONIDES ON THE GLUCURONIDE BIOSYNTHESIS
Acta Paediatrica, 1970O. HÄNNINEN, J. MARNIEMI
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