Results 211 to 220 of about 33,429 (298)
Rare Cholesterol Related Disorders – A Sterolomic Library for Diagnosis and Monitoring of Diseases
Asgari MA +19 more
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Drug Metabolism and Disposition, 2012
Glucuronidation reaction is catalyzed by mammalian uridine diphosphoglucuronosyl transferases by using uridine diphosphoglucuronic acid as a cosubstrate. Conjugation of glucuronic acid to nucleophilic functional groups in chemical entities results in formation of glucuronides. As anticipated, a number of nucleophilic functional groups such as hydroxyl,
U. Argikar
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Glucuronidation reaction is catalyzed by mammalian uridine diphosphoglucuronosyl transferases by using uridine diphosphoglucuronic acid as a cosubstrate. Conjugation of glucuronic acid to nucleophilic functional groups in chemical entities results in formation of glucuronides. As anticipated, a number of nucleophilic functional groups such as hydroxyl,
U. Argikar
openaire +3 more sources
Glucuronides: From biological waste to bio-nanomedical applications
Journal of Controlled Release, 2022Long considered as no more than biological waste meant to be eliminated in urine, glucuronides have recently contributed to tremendous developments in the biomedical field, particularly against cancer.
Chia-Ching Wu +2 more
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Targeted LC-MS/MS analysis of steroid glucuronides in human urine.
Journal of Steroid Biochemistry and Molecular Biology, 2020Conjugation with glucuronic acid is one of the major metabolic reactions in human steroid hormone catabolism. Recently, increasing interest has been raised concerning the biological roles of steroid glucuronides. We have therefore developed and validated
Rong Wang, M. Hartmann, S. Wudy
semanticscholar +1 more source
NEW PERSPECTIVES ON DRUG-INDUCED LIVER INJURY RISK ASSESSMENT OF ACYL GLUCURONIDES.
Chemical Research in Toxicology, 2020Drug-induced liver injury (DILI) remains one of the key challenges in drug development due to the mechanisms of action being multi-factorial in nature. This is particularly the case for idiosyncratic DILI which occurs in very low frequency in man (eg, 1 ...
M. Walles +3 more
semanticscholar +1 more source
Antioxidant and anti-inflammatory flavonol glucuronides from Polygonum aviculare L.
Fìtoterapìâ, 2013Anna Kiss +2 more
exaly +2 more sources
Effect of Glucuronides on Glucuronide Biosnthesis
European Journal of Biochemistry, 19711‐Naphthyl and phenolphthalein glucuronides were found to be potent inhibitors of p‐nitro‐phenyl glucuronide synthesis catalyzed by rat liver microsomal fraction. They did not compete with theaglycone, p‐nitrophenol, but with glucuronyl donor, UDPglucuronic acid.
O, Hänninen, J, Marniemi
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Glucuronidation of apomorphine
Life Sciences, 2000Apomorphine, a dopaminergic receptor agonist, is largely used in the therapy of Parkinson's disease. In this study, we characterized the glucuronidation of apomorphine and other catechols in rat liver and brain microsomes, using UDP-[U-14C]glucuronic acid and separation of the glucuronides formed by a thin layer chromatographic method.
R S, El-Bachá +4 more
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Xenobiotica, 1991
1. To expedite direct studies on phase II metabolites of fluphenazine, pure fluphenazine or 7-hydroxyfluphenazine were incubated with a rabbit hepatic microsomal immobilized enzyme system. After purification and recrystallization a high yield (60%) of 7-hydroxy-beta-D-O-glucuronyl-fluphenazine was obtained. 2.
C J, Jackson, J W, Hubbard, K K, Midha
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1. To expedite direct studies on phase II metabolites of fluphenazine, pure fluphenazine or 7-hydroxyfluphenazine were incubated with a rabbit hepatic microsomal immobilized enzyme system. After purification and recrystallization a high yield (60%) of 7-hydroxy-beta-D-O-glucuronyl-fluphenazine was obtained. 2.
C J, Jackson, J W, Hubbard, K K, Midha
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