Results 201 to 210 of about 41,898 (332)

Tomato-Soy Juice Reduces Inflammation and Modulates the Urinary Metabolome in Adults With Obesity. [PDF]

Mol Nutr Food Res
Sholola MJ, Miller J, Bilbrey EA, Novotny JA, Francis DM, Mace TA, Cooperstone JL.   +6 more
europepmc   +1 more source

Anabolic steroid glucuronides : Enzyme-assisted synthesis and liquid chromatographic-mass spectrometric analysis [PDF]

, 2003
Kuuranne, Tiia
core  

A model‐based analysis of the CYP2C9 genotype effects on fluconazole inhibition using flurbiprofen, ketoprofen and tolbutamide as probe drugs

British Journal of Pharmacology, Volume 183, Issue 10, Page 2482-2496, May 2026.
Background The activity of CYP2C9, an important drug metabolism enzyme, is subject to the impact of genetic polymorphism. The single nucleotide polymorphism *3 is significantly associated with the increased exposure of CYP2C9 substrates. In addition, metabolic enzyme inhibitors such as fluconazole may also increase the drug exposure of CYP2C9 ...
Shen Cheng, Darcy R. Flora, Mutaz M. Jaber, Allan E. Rettie, Richard C. Brundage, Timothy S. Tracy   +5 more
wiley   +1 more source

Trans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial. [PDF]

Front Aging
Rao A, Briskey D, Roche G, Tremblay A, Da Silva Pinto M, Tompkins TA.   +5 more
europepmc   +1 more source

Effect of Individual and Combined Cytochrome P450 Activity Scores on Symptom Improvement and Side Effects in Youth Treated With Sertraline

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Sertraline is commonly used to treat mental health conditions in youth. However, its tolerability and efficacy vary between individuals, partly due to interindividual differences in drug metabolism. This study assessed the individual and combined impact of genetic variation in cytochrome P450 drug‐metabolizing enzymes on patient‐reported side ...
Samuel Gerlach, Abdullah Al Maruf, Sarker M. Shaheen, Ryden McCloud, Madison Heintz, Laina McAusland, Paul D. Arnold, Chad A. Bousman   +7 more
wiley   +1 more source

Metabolites from South African Medicinal Plants as Dual-Function Inhibitors of the SARS-CoV-2 Papain-like Protease (PL^pro). [PDF]

Life (Basel)
Makhafola MA, Naidoo CM, Obi CL, Iweriebor BC, Olaokun OO, Prinsloo E, Kikuchi H, Zubair MS, Mkolo NM.   +8 more
europepmc   +1 more source

Predicting Pharmacokinetic Variability and Drug Interaction Risk Using Omics‐Based Biomarkers

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Interindividual variability in drug pharmacokinetics and susceptibility to drug–drug interactions remain major barriers in precision dosing, particularly for narrow therapeutic index drugs. While genetic factors contribute, much variability arises from dynamic influences such as physiology, disease, age, diet, microbiome, and concomitant ...
Bhagwat Prasad
wiley   +1 more source

Characterizing the Sulfated and Glucuronidated (Poly)phenol Metabolome for Dietary Biomarker Discovery. [PDF]

J Agric Food Chem
Tsiara I, Hervás Povo B, Alotaibi W, Young Tie Yang P, Rodriguez-Mateos A, Globisch D.   +5 more
europepmc   +1 more source

Pharmacogenetics of Mycophenolic Acid in Patients of African Descent: Underrepresentation of African Data

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Mycophenolic acid (MPA) is a potent antiproliferative immunosuppressive agent used to prevent organ transplant rejection and to treat various immune‐mediated diseases. MPA is the active metabolite formed from the biotransformation of the prodrugs mycophenolate mofetil (MMF) or enteric‐coated mycophenolate sodium (EC‐MPS).
Migael Mouton, Bianca Davidson, Jessica Taylor, Marc Blockman, Erika Jones, Robert Freercks, Khuthala Mnika, Collet Dandara   +7 more
wiley   +1 more source

Flavonoid Interactions with Renal Organic Anion Transporters OAT1 and OAT3: Structure-Activity Relationships and Clinical Implications. [PDF]

Int J Mol Sci
Tong K, Ye P, Kaneda-Nakashima K, Zhang H, Wei L.   +4 more
europepmc   +1 more source