Results 181 to 190 of about 41,898 (332)

Correlational and Molecular Mechanism Analyses of Bioactive Compounds From Ziziphus jujuba: Focusing on Anti‐Hyaluronidase and Antioxidant Networks

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Extract of Z. jujuba leaves and branches is prepared by using ethanol. The samples are examined for antioxidant and various enzyme inhibition activities. Then, bioactive components are isolated by column chromatography and identified by EI‐MS, NMR, and UV‐HPLC. Medicagenic acid may be the best candidate for anti‐hyaluronidase.
Saba Noreen, Zhaoyang Wu, Sichan Kim, Ji Won Choi, Soo Kyeong Lee, Deokho Lee, Soon Sung Lim   +6 more
wiley   +1 more source

Recurrent <i>SLCO1B1</i> and <i>SLCO1B3</i> mutations identified in three patients with Rotor syndrome. [PDF]

Front Med (Lausanne)
Zhao C, Huang H.
europepmc   +1 more source

Improved detection of opioid use in chronic pain patients through monitoring of opioid glucuronides in urine.

Journal of Analytical Toxicology, 2012
Jane A Dickerson, Thomas J. Laha, M. Pagano, Brendan R. O'donnell, A. Hoofnagle   +4 more
semanticscholar   +1 more source

Chemical Profiling, Pharmacological Activities, and Toxicity Assessment of Juniperus phoenicea sp. turbinata L. Extract: Integrated In Vitro, In Vivo, and In Silico Insights

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Hydroethanolic leaf and fruit extracts of Juniperus phoenicea showed high phenolic content, dominated by ferulic acid. Both extracts were non‐toxic and exhibited strong anti‐inflammatory, analgesic, antioxidant, and antimicrobial activities. Molecular docking confirmed stable binding to key inflammatory and microbial targets, supporting its ...
Tarik Chelouati, Soufyane Lafraxo, Amira Metouekel, Mostafa Messkini, Salah‐eddine Chebaibi, Abdelfattah E. L. Moussaoui, Azeddin El Barnossi, Esmael M. Alyami, Ohoud A. Alghamdi, Yousef A. Bin Jardan, Gehan M. Elossaily, Musaab Dauelbait, Musa A. Said, Ahmed Samir Benjelloun   +13 more
wiley   +1 more source

A Parent-Metabolite Middle-Out PBPK Model for Genistein and Its Glucuronide Metabolite in Rats: Integrating Liver and Enteric Metabolism with Hepatobiliary and Enteroluminal Transport to Assess Glucuronide Recycling. [PDF]

Pharmaceutics
Ramisetty BS, Singh R, Hu M, Wang MZ.
europepmc   +1 more source

Oxalis corniculata L. Ethanol Extract Promotes Fracture Healing: Integrated Omics and Experimental Validation

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Oxalis corniculata L. ethanol extract (OCEE) showed efficacy in promoting fracture healing. A total of 549 compounds were identified by UHPLC‐Q‐Exactive‐MS/MS, with three key components recognized. OCEE may accelerate fracture healing by regulating TNFα, MMP9, ESR1, TP53, and related signaling pathways. ABSTRACT Oxalis corniculata L.
Jian Zhang, Xiaorong Zhao, Xiaoyan Long, Yu Zhang, Xuegang Luo, Wanyan Shen   +5 more
wiley   +1 more source

Investigation of commercially available recombinant and conventional β-glucuronidases to evaluate the hydrolysis efficiencies against O-glucuronides and N-glucuronides in urinary drug screening. [PDF]

Forensic Toxicol
Namera A, Saito T, Nagao M.
europepmc   +1 more source

Randomized, Placebo‐Controlled, First‐in‐Human Study of the Safety, Tolerability, and Pharmacokinetics of Single and Repeat Oral Doses of Novel Antitubercular Drug Candidate, GSK2556286, in Healthy Adults

The Journal of Clinical Pharmacology, Volume 66, Issue 5, May 2026.
Abstract This first‐in‐human study (ClinicalTrials.gov identifier: NCT04472897) evaluated the safety, tolerability, pharmacokinetics, and food effect of single ascending and repeat oral doses of GSK2556286 (GSK286), a novel antitubercular drug candidate with efficacy in animal models of tuberculosis.
Emma Ilsley, Edward Banham‐Hall, Tetyana Chaychenko, Katerina Chinenyeze, Gareth Maher‐Edwards, Catherine Muya, Katie Rolfe, Raman Sharma, Simon Tiberi, David Barros‐Aguirre   +9 more
wiley   +1 more source

Hepatic uptake of estradiol-3-glucuronide and estradiol-3-sulfate-17β-glucuronide by human organic anion transporting polypeptides 1B1, 1B3, and 2B1. [PDF]

Drug Metab Dispos
Li L, Huan R, Liang T, Liu H, Dong Y, Chen S, Zhang C, Gui C.   +7 more
europepmc   +1 more source

Turmeric and curcumin: From traditional medicine to modern therapeutic applications

JSFA reports, Volume 6, Issue 5, Page 160-178, May 2026.
Abstract Turmeric (Curcuma longa), a medicinal plant, has maintained its cultural and therapeutic significance over centuries in Ayurveda, Unani, and Traditional Chinese Medicine. However, novel formulations and delivery methods are being developed to address these challenges.
Azma Nadeem, Khurram Afzal, Asad Abbas, Talha Bin Iqbal, Abdul Malik, Javaria Saeed, Mutjardah Zarrish, Bipindra Pandey   +7 more
wiley   +1 more source