Results 41 to 50 of about 12,956 (251)

The Application of LC-MS in Forensic Toxicology

CHIMIA, 2002
Analyses by LC-MS are of increasing importance in forensic toxicology and related fields. Some specific applications are discussed including the analysis of some drugs of abuse and other toxicologically highly relevant drugs like benzodiazepines,
Franz E. Dussy, Cornelia Hamberg Stäubli, Thomas A. Briellmann   +2 more
doaj   +1 more source

Unveiling Hepatic Protein Alterations in Neonatal and Infant Biliary Atresia

Clinical Pharmacology &Therapeutics, EarlyView.
Pediatric populations differ from adults in drug elimination capacity. While current scaling methods account for enzyme and transporter maturation, they overlook comorbidities, such as biliary atresia (BA), a liver disease appearing within the first 2–8 weeks of life that can progress to cirrhosis.
Zubida M. Al‐Majdoub, Martyn Howard, Brahim Achour, Jill Barber, Naved Alizai, Amin Rostami‐Hodjegan   +5 more
wiley   +1 more source

Advances in Human Mass Balance Studies: An IQ Consortium Perspective on Current Practices and Emerging Trends

Clinical Pharmacology &Therapeutics, EarlyView.
Human radiolabeled mass balance studies are crucial for comprehensively characterizing the absorption, distribution, metabolism, and excretion (ADME) of investigational drugs, providing essential data for drug development, regulatory evaluation, and product labeling.
Jason Boer, Ellen Cannady, Filip Cuyckens, Ulrike Glaenzel, Camille Granvil, Felix Huth, Alexander D. James, Wenying Li, Céline Veau, Graeme Young, Qin Yue, Gregory S. Walker, Upendra A. Argikar, Jonathan N. Bauman, Cathy Cantalloube, Yu‐Luan Chen, Ping Kang, Patricia Moliner, Mette L. Pedersen, Isabel Piel, Simone Schadt, Hanno Schieferstein, Julia Suchomel, Shuai Wang, S. Cyrus Khojasteh   +24 more
wiley   +1 more source

Regioselective Glucuronidation of Diosmetin and Chrysoeriol by the Interplay of Glucuronidation and Transport in UGT1A9-Overexpressing HeLa Cells.

PLoS ONE, 2016
This study aimed to determine the reaction kinetics of the regioselective glucuronidation of diosmetin and chrysoeriol, two important methylated metabolites of luteolin, by human liver microsomes (HLMs) and uridine-5'-diphosphate glucuronosyltransferase (
Xuejun Zeng, Jian Shi, Min Zhao, Qingwei Chen, Liping Wang, Huangyu Jiang, Feifei Luo, Lijun Zhu, Linlin Lu, Xinchun Wang, Zhongqiu Liu   +10 more
doaj   +1 more source

APRECIEREA PARAMETRILOR DE CALITATE ȘI SIGURANȚĂ LA CARNEA DE PASĂRE REFRIGERATĂ, REALIZATĂ ÎN CONSUMUL PUBLIC

Agricultural Science, 2023
The study assessed the quality and safety parameters of poultry meat from two local producers. Broiler chicken carcasses, refrigerated and packed in polyethylene, were collected from the marketing network for laboratory evaluations at the Republican ...
Alisa PÎRLOG
doaj   +1 more source

Statistical Discrimination of Urinary Steroid Biomarkers in the Athlete Biological Passport: A Novel Approach to an Abnormal Steroid Profile Score (ASPS)

Drug Testing and Analysis, EarlyView.
The study developed a single Abnormal Steroid Profile Score (ASPS) to improve interpretation of the Athlete Biological Passport steroid module. Using Bayesian modelling and logistic regression, biomarker patterns from laboratory and doping control data successfully discriminated between doped and clean individuals, with improved classification ...
James G. Hopker, Jim E. Griffin, Matthew N. Fedoruk, Laura A. Lewis   +3 more
wiley   +1 more source

Evaluation of Different Detection and Identification Methods of Intact Tetrahydro‐Methyltestosterone Sulfate Metabolites in Doping Control

Drug Testing and Analysis, EarlyView.
The micro‐scale synthesis of the six out of eight possible tetrahydro‐methyltestosterone sulfate metabolites was performed, and the synthesized materials were used as analytical standards. The analysis of post‐administration sample extracts from methyltestosterone excretion studies against these standards provides further experimental proof for their ...
Yiannis S. Angelis, Olga Goula, Polyxeni Kiousi, Panagiotis Sakellariou   +3 more
wiley   +1 more source

IN VITRO IRREVERSIBLE BINDING AND DEGRADATION OF (R)- AND (S)-KETOPROFEN GLUCURONIDES TO PLASMA PROTEINS [PDF]

Malaysian Journal of Pharmaceutical Sciences, 2007
This study describes the in vitro degradation studies of the diastereomeric ketoprofen glucuronides, under physiological conditions (pH 7.4, 37°C, (R)-ketoprofen glucuronide t½ = 30 min, (S)-ketoprofen glucuronide t½ = 70 min) and the irreversible ...
PETER J. HAYBALL, KELLIE L. TUCK
doaj  

In Vivo and In Vitro Evaluation of PTeCA (1H‐Pyrrole‐2,3,4,5‐Tetracarboxylic Acid) in Hair Matrix as a Marker for Oxidative Cosmetic Treatment

Drug Testing and Analysis, EarlyView.
A total of 3378 self‐reported treated and untreated hair samples were analyzed for PTCA and PTeCA by LC‐MS/MS. Moreover, their in vitro formation was assessed in 225 untreated hair by different cosmetic treatments with and without oxidative agents. Data suggest that PTeCA could be a reliable marker for oxidative cosmetic treatments in hair.
Sara Casati, Alessandro Ravelli, Roberta F. Bergamaschi, Agata Magliocco, Sofia Vanerio, Gabriella Roda, Paola Rota, Marica Orioli, Alessio Battistini   +8 more
wiley   +1 more source

In Vitro Metabolism of DWP16001, a Novel Sodium-Glucose Cotransporter 2 Inhibitor, in Human and Animal Hepatocytes

Pharmaceutics, 2020
DWP16001 is currently in a phase 2 clinical trial as a novel anti-diabetes drug for the treatment of type 2 diabetes by selective inhibition of sodium-glucose cotransporter 2.
Ju-Hyun Kim, Dong Kyun Kim, Won-Gu Choi, Hye-Young Ji, Ji-Soo Choi, Im-Sook Song, Sangkyu Lee, Hye Suk Lee   +7 more
doaj   +1 more source