Results 91 to 100 of about 30,656 (311)
The Journal of Clinical Pharmacology, EarlyView.Abstract To assess the antitussive effects of dextrorphan (DOR) relative to its parent compound, dextromethorphan (DEX) a double‐blind, randomized, placebo‐controlled crossover study was conducted in 23 healthy volunteers using citric acid cough challenge test after administering placebo, DEX, or DOR.
Saeed Rezaee +3 more
wiley +1 more source
Weekly irinotecan in a patient with metastatic colorectal cancer on hemodialysis due to chronic renal failure [PDF]
, 2002 Background: The cytotoxic treatment of patients suffering from advanced or metastatic cancer undergoing hemodialysis due to chronic renal failure still remains a problem, since for those patients pharmacokinetic and pharmacodynamic data on most cytotoxic
Hacker, U. +4 more
core +1 more source
Pest Management Science, EarlyView.Assembly of Ctenoplusia agnata genome at the chromosomal level and the use of pest management through comparative genomes with Plusiinae pests. Abstract BACKGROUND Ctenoplusia agnata is a polyphagous pest affecting bean crops and cruciferous vegetables across East Asian countries, including Korea.
Juil Kim +2 more
wiley +1 more source
Cancer Science, EarlyView.FOLFIRINOX improves the prognosis of patients with pancreatic cancer; however, despite UGT1A1 screening, adverse events, such as severe neutropenia, occur frequently. The diagnostic performance of the neutropenia prediction model showed areas under the curve of 0.754 (sensitivity=0.605, specificity=0.848) and 0.856 (sensitivity=0.800, specificity=0.893)
Gen Kanesada +9 more
wiley +1 more source
Inhibition of UDP-glucuronosyltransferases by different furoquinoline alkaloids
Xenobiotica, 2020 Herbs are often administered in combination with therapeutic drugs, raising the possibility for herb–drug interactions (HDIs). Furoquinoline alkaloids are found in Rutaceae plants, which are structurally similar and have many medicinal properties. This study aims to investigate the inhibition of four furoquinoline alkaloids on the activity of UDP ...
Ce Wang +8 more
openaire +3 more sources
Deficiency of Aging‐Related Gene Chitinase‐Like 4 Impairs Olfactory Epithelium Homeostasis
Cell Proliferation, EarlyView.Deficiency of Chil4 impairs OE homeostasis through loss of sustentacular cells and a specific type of immature sensory neuron, cell cycle arrest in globose basal cells, and inflammatory activation in microglia‐like cells. ABSTRACT Mammalian olfactory epithelium (OE) undergoes consistent self‐renewal throughout life.
Tingting Wu +7 more
wiley +1 more source
The clinical application of
Human Genomics, 2010 Over the past decade, the number of pharmacogenetic tests has increased considerably, allowing for the development of our knowledge of their clinical application.
Marques Sara, Ikediobi Ogechi N
doaj +1 more source
BMC Plant Biology, 2020 Background Arabinogalactan-proteins (AGPs) are one of the most complex protein families in the plant kingdom and are present in the cell walls of all land plants.
Yuan Zhang +2 more
doaj +1 more source
Status epilepticus in older adults: A critical review
Epilepsia, EarlyView.Abstract Older adults (≥60 years of age) have the highest incidence of status epilepticus (SE) among adults and experience the highest morbidity and mortality. SE incidence increases with age in adulthood. A recent study from Austria estimated an incidence of 89.6/100 000 and 67.6/100 000 person‐years adjusted for age and sex in women and men aged >60 ...
Matthew R. Woodward +5 more
wiley +1 more source
A new case of (TA)8 allele in the UGT1A1 gene promoter in a caucasian girl with Gilbert' syndrome [PDF]
, 2004 The authors describe a 5-year-old Caucasian girl, referred to their hospital for evaluation of an unconjugated hyperbilirubinemia (57.9 μmol/L) detected from blood analysis during an episode of fever. The molecular analysis of the TATA-box region of the
Barbot, José +4 more
core +1 more source