Results 111 to 120 of about 14,230 (233)

A Comparative Analysis of Michaelis-Menten, Hill, and Allosteric Models in Drug Metabolism

Iraqi Journal of Industrial Research
Background: Enzyme Kinetics it is a fundamental part of metabolic biochemistry because it helps to explore the mechanism of action and interaction of all substrates under the influence as well as environmental factors.
Ziyad K. Radeef
doaj   +1 more source

Isoform-Selective Inhibition of the Human UDP-glucuronosyltransferase 2B7 by Isolongifolol Derivatives

, 2016
A set of 48 derivatives of the tricyclic sesquiterpenol alcohol isolongifolol was synthesized. The set comprised homochiral and diastereomeric alcohols, amines, chlorohydrins, as well as carboxylic acids, phosphonic acids, and their corresponding esters.
Mika Kurkela (2489923), Tanmaya Joshi (1801927), Bohumila Suchanová (2489920), Mikko Vahermo (1671241), Ingo Bichlmaier (2489926), Tobias Rüffer (1388916), Antti Siiskonen (1671244), Heinrich Lang (1388919), Moshe Finel (276411), Jari Yli-Kauhaluoma (276410)   +9 more
core   +1 more source

PhD

, 2008
dissertationThe UDP-glucuronosyltransferase (GT) enzyme from ethanol-induced male New Zealand white rabbit hepatic protein was purified to homogeneity and characterized.
Hutabarat, Renta Magdalena.
core  

Hepatic and Extrahepatic Glucur- onidation of Bile Acids in Man Characterization of Bile Acid Uridine 5'-Diphosphate-Glucuronosyltransferase in Hepatic, Renal, and Intestinal Microsomes

, 2020
. Microsomal UDP-glucuronosyltransferase activity toward the bile acids (chenodeoxycholic, deoxycholic, ursodeoxycholic, lithocholic, and glycolithocholic) has been detected in human specimens of liver, kidney, and intestinal mucosa.
S Matem, H Matem, W Gerok, E H Farthmann
core  

Phospholipids and UDP-glucuronosyltransferase. Structure/function relationships.

, 1988
The activation of delipidated microsomal UDP-glucuronosyltransferase from pig liver (GT2P type of enzyme) was studied as a function of several structural modifications of 1-palmitoyl-sn-glycero-3-phosphocholine, which is known to be a good activator of ...
Cantor, M., Eibl, H., Zakim, D.
core  

In vivo modification of the UDP-glucuronosyltransferase functional state in rat liver following hypophysectomy and partial or complete hormonal restoration

, 2003
International audienceThe effects of growth hormone on the uridine diphosphate glucuronosyltransferase functional state, biophysical membrane parameters (order parameters and rotational correlation frequency) and the composition in phospholipids were ...
Daveloose, Denis, Paris, Alain, A., Vezin, Hervé, Guéraud, Françoise, Viret, Jacques   +4 more
core   +1 more source

Simultaneous Screening of Activities of Five Cytochrome P450 and Four Uridine 59-Diphospho-glucuronosyltransferase Enzymes in Human Liver Microsomes Using Cocktail Incubation and Liquid Chromatography-Tandem Mass Spectrometry s

, 2020
Cytochrome P450 (P450) and uridine 59-diphospho-glucuronosyltransferase (UGT) are major metabolizing enzymes in the biotransformation of most drugs.
Hyeon-Kyeong Ji, Taeho Lee, Boram Lee, Kwang-Hyeon Liu   +3 more
core  

Uridine diphosphate glucuronosyltransferase 1A1 gene polymorphisms and treatment outcomes in HIV and MTB coinfection in sub-Saharan Africa: a scoping review protocol. [PDF]

BMJ Open
Vhanda D, Musarurwa C, Chikwati RP, Muziringa M, Dandara C, Manasa J, Chirenda J, Mavenyengwa RT.   +7 more
europepmc   +1 more source

The Impact of <i>UGT1A1</i> Genetic Variability on Enzyme Expression in Liver Pathology. [PDF]

Genes (Basel)
Szeląg-Pieniek S, Kucak J, Malinowski D, Oswald S, Droździk M, Kurzawski M.   +5 more
europepmc   +1 more source

Design, expression, purification, and application of novel recombinant miR-491 molecules to define the biogenesis and function of miR-491-3p versus -5p in posttranscriptional regulation of UDP-glucuronosyltransferase 1A1. [PDF]

Drug Metab Dispos
Wang Y, Tu MJ, Batra N, Guan S, Zhou Y, Yu AM.   +5 more
europepmc   +1 more source