Results 91 to 100 of about 14,230 (233)

Could Postnatal Age–Related Uridine Diphosphate Glucuronic Acid Be a Rate‐Limiting Factor in the Metabolism of Morphine During the First Week of Life?

CPT: Pharmacometrics & Systems Pharmacology, 2019
Neonates experience dramatic changes in the disposition of drugs after birth as a result of enzyme maturation and environmental adjustment, challenging therapeutic decision making. In this research, we establish postnatal age, postmenstrual age, and body
Tao Liu, Tamorah R. Lewis, Jason N. Moore, Walter K. Kraft, Estelle B. Gauda, David Sartori, David E. Moody, Jogarao V. S. Gobburu, Vijay Ivaturi   +8 more
doaj   +1 more source

The UDP glucuronosyltransferase gene superfamily: suggested nomenclature based on evolutionary divergence

, 1991
A nomenclature system for the UDP glucuronosyltransferase superfamily is proposed, based on divergent evolution of the genes. A total of 26 distinct cDNAs in five mammalian species have been sequenced to date.
Lancet, D., Chowdhury, J. R., Jansen, P. L., Nebert, D. W., Nelson, D. R., Mulder, G. J., Iyanagi, T., Bock, K. W., Burchell, B., Siest, G.   +9 more
core   +1 more source

Long-term efficacy and safety of raltegravir in the management of HIV infection

Infection and Drug Resistance, 2014
Michelle D Liedtke, C Ryan Tomlin, Staci M Lockhart, Misty M Miller, R Chris Rathbun Department of Clinical and Administrative Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA Abstract: Raltegravir is ...
Liedtke MD, Tomlin CR, Lockhart SM, Miller MM, Rathbun RC   +4 more
doaj  

Prevalence of UDP-glucuronosyltransferase polymorphisms (UGT1A6∗2, 1A7∗12, 1A8∗3, 1A9∗3, 2B7∗2, and 2B15∗2) in a

Saudi Pharmaceutical Journal, 2017
Glucuronidation is an important phase II pathway responsible for many endogenous substances and drug metabolism. The present work evaluated allele frequencies of certain UDP-glucuronosyl-transferases (UGT 1A6∗2, A7∗12, A8∗3, A9∗3, 2B7∗2, and 2B15∗2) in ...
Khalid M. Alkharfy, Basit L. Jan, Sibtain Afzal, Fahad I. Al-Jenoobi, Abdullah M. Al-Mohizea, Saleh Al-Muhsen, Rabih Halwani, Mohammad K. Parvez, Mohammed S. Al-Dosari   +8 more
doaj   +1 more source

Bilirubin-uridine diphosphate glucuronosyltransferase (UGT1A1) gene mutations among newborn babies in the Malay population in Kelantan with hyperbilirubinaemia [RJ276. S961 2005 f rb]. [PDF]

, 2005
Sindrom Gilbert berpunca daripada keabnormalan pada gen uridine diphosphate-glucuronosyltransferase 1A1 (UGT1A1) yang disebabkan oleh mutasi. Gilbert syndrome is caused by defects in the uridine diphosphateglucuronosyltransferase 1A1 (UGT1A1 ...
Yusoff, Surini, Yusoff, Surini
core  

Transcriptomic Association Analysis of the Metabolic Mechanism of Sulfamethoxazole in Channel Catfish (Ictalurus punctatus)

Animals
Sulfamethoxazole is a widely used antimicrobial drug used to treat bacterial diseases in aquaculture. To understand the gene expression in channel catfish liver after treatment with sulfamethoxazole, in this study, the treatment group received ...
Xiangxuan Du, Ruyu Sun, Lei Zhang, Yongtao Liu, Xiaohui Ai   +4 more
doaj   +1 more source

Human UDP-Glucuronosyltransferase 2B4 and 2B7 Are Responsible for Naftopidil Glucuronidation in Vitro

Frontiers in Pharmacology, 2018
Naftopidil (NAF) is widely used for the treatment of benign prostatic hyperplasia and prevention of prostate cancer in elderly men. These patients receive a combination of drugs, which involves high risk for drug–drug interaction.
Xia-Wen Liu, Yi Rong, Xing-Fei Zhang, Jun-Jun Huang, Yi Cai, Bi-Yun Huang, Liu Zhu, Bo Wu, Ning Hou, Cheng-Feng Luo   +9 more
doaj   +1 more source

Frequencies of UDP-glucuronosyltransferase 1 (UGT1A1) gene promoter Polymorphisms among distinct ethnic groups from Brazil

, 2015
A polymorphism in the promoter region of the UDP-glucuronosyltransferase 1 (UGT1A) gene is associated with Gilbert syndrome (GS), a benign form of mild unconjugated hyperbilirubinemia.
Goncalves, MS, Fertrin, KY, Saad, STO, Costa, FF   +3 more
core   +1 more source

Isolation and characterisation of a new hepatic bilirubin UDP-glucuronosyltransferase Absence from Gunn rat liver

, 1992
A novel UDP-glucuronosyltransferase that conjugates bilirubin IXα, bilirubin monoglucuronide and an arylalkanoic acid was purified to homogeneity from clofibrate treated Wistar rats.
Brian Burchell, Keen, Jeffrey N., Jeffrey N. Keen, Clarke, Douglas J., Douglas J. Clarke, Burchell, Brian   +5 more
core   +1 more source

The Ontogeny of UDP-glucuronosyltransferase Enzymes, Recommendations for Future Profiling Studies and Application Through Physiologically Based Pharmacokinetic Modelling

, 2019
Limited understanding of drug pharmacokinetics in children is one of the major challenges in paediatric drug development. This is most critical in neonates and infants owing to rapid changes in physiological functions, especially in the activity of drug ...
Schmidt, S., Schmidt, S, Wildt, S.N. de, Collier, AC, Parrott, N, Fowler, S., Fowler, S, Parrott, N., Collier, A.C., Badee, J, de Wildt, Saskia, Badee, J.   +11 more
core   +1 more source