Results 81 to 90 of about 14,230 (233)

Is Ceftriaxone-Induced Biliary Pseudolithiasis Influenced by UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms?

Case Reports in Medicine, 2011
Ceftriaxone (cfx), a third-generation cephalosporin antibiotic, leads to transient cholelithiasis in some children, also known as pseudolithiasis. However, the underlying pathogenetic mechanism of this adverse effect has not yet been elucidated.
Andrew Fretzayas, Olga Liapi, Anna Papadopoulou, Polyxeni Nicolaidou, Alexandra Stamoulakatou   +4 more
doaj   +1 more source

Cholestasis in Crigler–Najjar Syndrome Type I: An Uncommon Histopathological Finding in a Rare Disorder

Indian Journal of Medical Specialities
Crigler–Najjar syndrome is a rare autosomal recessive disorder characterized by severe unconjugated hyperbilirubinemia. Liver histopathology in Crigler–Najjar Syndrome typically reveals fibrosis, while features of cholestasis are rarely reported.
N. Namratha, Nisha Yadav, Manish Narang, Sumaira Khalil   +3 more
doaj   +1 more source

UDP-Glucuronosyltransferase Promoter Polymorphism in Iranian Neonates with Idiopathic Hyperbilirubinemia

Acta Medica Iranica, 2013
To determine the association between polymorphism of UGT1A1 gene and idiopathic hyperbilirubinemia in Iranian neonates. Fifty neonates with idiopathic hyperbilirubinemia and Serum total bilirubin (STB) more that 15mg/dl and 50 neonates with idiopathic ...
Mahbod Kaveh, Tahereh Esmailnia, Fatemeh Nayeri, Firoozeh Nili, Fatemeh Davari Tanha, Mahsa Ghajarzdeh   +5 more
doaj  

Antiretroviral Drug Interactions: Overview of Interactions Involving New and Investigational Agents and the Role of Therapeutic Drug Monitoring for Management

Pharmaceutics, 2011
Antiretrovirals are prone to drug-drug and drug-food interactions that can result in subtherapeutic or supratherapeutic concentrations. Interactions between antiretrovirals and medications for other diseases are common due to shared metabolism through ...
R. Chris Rathbun, Michelle D. Liedtke
doaj   +1 more source

CHARACTERIZATION OF AFLOQUALONE N-GLUCURONIDATION: SPECIES DIFFERENCES AND IDENTIFICATION OF HUMAN UDP-GLUCURONOSYLTRANSFERASE ISOFORM(S)

, 2020
: Afloqualone (AFQ) is one of the centrally acting muscle relaxants. AFQ N-glucuronide is the most abundant metabolite in human urine when administered orally, whereas it was not detected in the urine when administered to rats, dogs, and monkeys. Species
Toshiyuki Kume, Hidefumi Kaji
core  

Functional Characterization of Low-Prevalence Missense Polymorphisms in the UDP-Glucuronosyltransferase 1A9 Gene□S [PDF]

, 2008
The UDP-glucuronosyltransferase (UGT) 1A9 has been shown to play an important role in the detoxification of several carcinogens and clearance of anticancer and pain medications.
Olson, Kristine C, Shantu Amin, Zhong, Qing, Philip Lazarus, Amin, Shantu, Ryan W. Dellinger, Spratt, Thomas E, Dongxiao Sun, Lazarus, Philip, Sun, Dongxiao, Kristine C. Olson, Thomas E. Spratt, Dellinger, Ryan W, Qing Zhong   +13 more
core   +1 more source

Dietary moderately oxidized oil activates the Nrf2 signaling pathway in the liver of pigs

Lipids in Health and Disease, 2012
Background Previous studies have shown that administration of oxidized oils increases gene expression and activities of various enzymes involved in xenobiotic metabolism and stress response in the liver of rats and guinea pigs.
Varady Juliane, Gessner Denise K, Most Erika, Eder Klaus, Ringseis Robert   +4 more
doaj   +1 more source

Pharmacogenomics of human UDP-glucuronosyltransferase enzymes [PDF]

The Pharmacogenomics Journal, 2003
UDP-glucuronosyltransferase (UGT) enzymes comprise a superfamily of key proteins that catalyze the glucuronidation reaction on a wide range of structurally diverse endogenous and exogenous chemicals. Glucuronidation is one of the major phase II drug-metabolizing reactions that contributes to drug biotransformation.
openaire   +2 more sources

Udp-glucuronosyltransferase 1 Gene Promoter Polymorphism Is Associated With Increased Serum Bilirubin Levels And Cholecystectomy In Patients With Sickle Cell Anemia [1]

, 2015
[No abstract available]642160162Bosma, P.J., Chowdury, J.R., Bakker, C., The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome (1995) N. Engl. J. Med., 333, pp.
Fertrin K.Y., Assis A.M., Costa F.F., Saad S.T.O., Melo M.B.   +4 more
core   +1 more source

Characterization of Hepatic and Intestinal Glucuronidation of Magnolol: Application of the Relative Activity Factor Approach to Decipher the Contributions of Multiple UDP-Glucuronosyltransferase Isoforms

, 2011
Magnolol is a food additive that is often found in mints and gums. Human exposure to this compound can reach a high dose; thus, characterization of magnolol disposition in humans is very important.
Ling Yang, Finel, Moshe, Zhongze Fang, He, Guiyuan, Liang, Sicheng, Hongbo Zhang, Liu, Huixin, Dong, Peipei, 杨凌, Peipei Dong, Fang, Zhongze, Zhang, Hongbo, Moshe Finel, Zhu, Liangliang, Huixin Liu, Liangliang Zhu, Guangbo Ge, Guiyuan He, Ge, Guangbo, Yanyan Zhang, Sicheng Liang, Yang, Ling, Zhang, Yanyan   +22 more
core   +1 more source