Results 61 to 70 of about 14,230 (233)

Arzneimittelinteraktionen über das humane hepatische Phase-II-Enzym UDP-Glucuronosyltransferase (UGT) [PDF]

, 2010
In der Arbeit „Arzneimittelinteraktionen über das humane hepatische Phase-II-Enzym UDP-Glucuronosyltransferase (UGT)“ wurden die Ergebnisse einer ausführlichen Literaturrecherche in eine Tabelle übertragen, aus der die Abbauwege von 500 ...
Schuster, Claudia
core   +1 more source

Transcriptional responses of Aedes aegypti chemosensory tissues in response to volatile DEET and citronella oil

Insect Molecular Biology, EarlyView.
Aedes aegypti females were significantly repelled by both volatile DEET and citronella oil in comparison to control (ethanol‐exposed) mosquitoes. Global gene expression changes were largest in the mosquito mouthparts, with notable downregulation of the three subunits comprising the mosquito CO2 receptor (Gr1, 2 and 3).
Ivan Drahun, Jessica M. Sparrow, Cody W. Koloski, Bryan J. Cassone   +3 more
wiley   +1 more source

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source

The Genetic Basis of the Reduced Expression of Bilirubin UDP-Glucuronosyltransferase 1 in Gilbert's Syndrome

, 1995
Background. People with Gilbert's syndrome have mild, chronic unconjugated hyperbilirubinemia in the absence of liver disease or overt hemolysis. Hepatic glucuronidating activity, essential for efficient biliary excretion of bilirubin, is reduced to ...
Gantla, S, Bakker, C., Ben A. Oostra, Chowdhury, J R, Conny Bakker, TYTGAT, GNJ, CHOWDHURY, NR, Jansen, P L M, Elferink, R P J O, DEBOER, A, OOSTRA, BA, de Boer, A, Jayanta Roy Chowdhury, Lindhout, D, Anita de Boer, Oostra, B. A., Oude Elferink, R. P., Jansen, P. L., Ronald P.J. Oude Elferink, Lindhout, D., JANSEN, PLM, Piter J. Bosma, Shailaja Gantla, Namita Roy Chowdhury, Chowdhury, J. R., Guido N.J. Tytgat, Oostra, B A, Dick Lindhout, Bosma, P. J., de Boer, Anita, ELFERINK, RPJO, Gantla, S., Peter L.M. Jansen, CHOWDHURY, [No Value], Tytgat, G N J, Chowdhury, N R, Tytgat, G. N.   +36 more
core   +1 more source

Genome assembly of Elcysma westwoodi provides insights into host‐plant cyanogenic glucoside detoxification and chemical defence gene evolution

Insect Molecular Biology, EarlyView.
A chromosome‐level genome of Elcysma westwoodi was assembled. The genome encodes 272 detoxification‐related genes. A single‐copy bCAS was retained for cyanide detoxification. CYP405A and CYP332A were recruited into cyanogenic defence evolution. UGT33A retained a conserved GT‐B fold and catalytic domains.
Minyoung Choi, Murtaza Khan, Juil Kim
wiley   +1 more source

Effect of different detergent systems on the molecular size of UDP glucuronosyltransferase and other microsomal drug-metabolizing enzymes

, 1984
Mouse liver microsomes were solubilized in various detergent systems, and the resulting aggregate structures associated with cytochrome P-450, cytochrome c reductase, and UDP glucuronosyltransferase were sized by gel filtration chromatography. Cholate or
Mackenzie, Peter I., Lang, Matti A., Owens, Ida S.   +2 more
core   +1 more source

Regulation of Sulfotransferase and UDP-Glucuronosyltransferase Gene Expression by the PPARs

PPAR Research, 2009
During phase II metabolism, a substrate is rendered more hydrophilic through the covalent attachment of an endogenous molecule. The cytosolic sulfotransferase (SULT) and UDP-glucuronosyltransferase (UGT) families of enzymes account for the majority of ...
Melissa Runge-Morris, Thomas A. Kocarek
doaj   +1 more source

Genomic variation drives plant flavor diversification

Journal of Integrative Plant Biology, EarlyView.
This review explains how genomic variation shapes plant flavor by altering the biosynthetic and regulatory pathways of key attributes like sweetness, acidity, bitterness, piquancy, astringency, and aroma. It also discusses how multi‐omics, AI‐assisted breeding, and gene editing can translate this knowledge into plants with improved flavor, nutrition ...
Huimin Hu, Yanwei Hao, Yiwei Zhou, Xia Zhang, Rui Xia, Pan Liao   +5 more
wiley   +1 more source

The UDP-glucuronosyltransferase 1A6 isozyme is responsible for protocatechuic aldehyde glucuronidation in human live

, 2008
Glucuronidation is an important pathway in the metabolism of protocatechuic aldehyde (3,4-dihydroxybenzaldehyde, PAL). However, the metabolites and primary UDP-glucuronosyltransferase (UGT) isozymes responsible for PAL glucuronidation remain to be ...
杨凌, 邹汉法, 刘慧鑫
core  

Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions

, 2013
Pyrethroid insecticides are used to control diseases spread by arthropods. We have developed a suite of pyrethroid mimetic activity-based probes (PyABPs) to selectively label and identify P450s associated with pyrethroid metabolism.
O'Neill, Paul, Paine, Mark, Henderson, Colin, Hong, David W., Hong, David, Cravatt, Benjamin F., O'Neill, Paul M., Henderson, Colin J., Mahmoud, Hanafy, Finn, Robert D., Paine, Mark J. I., Finn, Robert, Ismail, Hanafy, Wright, Aaron T., Cravatt, Benjamin, Wright, Aaron, Paine, Mark; id_orcid, Hemingway, Janet, Ismail, Hanafy M.   +18 more
core   +1 more source