Results 51 to 60 of about 12,220 (202)

The gut microbiome and drug‐resistant epilepsy: Microbiome–antiseizure medication interactions and implications for pharmacoresistance

Epilepsia Open, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar, Majd A. AbuAlrob, Musab Ali, Simona Lattanzi, Boulenouar Mesraoua   +4 more
wiley   +1 more source

DPYD and UGT1A1 Genotype‐Based Dosing for Fluoropyrimidines and Irinotecan Chemotherapy: Variant‐Specific Impact on Treatment Intensity and Toxicity

International Journal of Cancer, EarlyView.
Pre‐treatment DPYD and UGT1A1 genotyping is increasingly used to prevent fluoropyrimidine‐ and irinotecan‐related toxicity, but variant‐specific real‐world effects remain unclear. In an unselected cohort of cancer patients with actionable genotypes, genotype‐driven dosing improved safety while preserving treatment exposure in high‐risk DPYD c.1905+1G>A
Martina Gambron, Elena Peruzzi, Samantha Perfler, Marcella Montico, Riccardo Cecchin, Elena De Mattia, Michele Spina, Camilla Lisanti, Serena Corsetti, Luisa Foltran, Fabio Puglisi, Rossana Roncato, Erika Cecchin   +12 more
wiley   +1 more source

Gymnema sylvestre: Bioactive constituents, health benefits, and emerging applications in nutraceuticals and functional foods

JSFA reports, EarlyView.
Abstract Gymnema sylvestre (Retz.) R.Br. ex‐Schult., commonly known as “gurmar” or “sugar destroyer,” belongs to the Apocynaceae family and is traditionally used in Ayurveda for diabetes management. This review synthesizes ethnomedicinal evidence with contemporary pharmacological studies, to evaluate the therapeutic properties and mechanistic actions ...
Faiza Saeed, Muhammad Tauseef Sultan, Hassan Raza, Ahmad Mujtaba Noman, Nimra Haroon, Entessar Mohammad Al Jbawi   +5 more
wiley   +1 more source

17β-Estradiol up-regulates UDP-glucuronosyltransferase 1A9 expression via estrogen receptor α

Acta Pharmaceutica Sinica B, 2016
UDP-glucuronosyltransferase 1A9 (UGT1A9) is a major phase II enzyme responsible for elimination of drugs and endogenous molecules. Clinical data have shown increased elimination of UGT1A9 substrates in pregnant women or oral contraceptive users, but the ...
Sung-joon Cho, Miaoran Ning, Yanyan Zhang, Leah H. Rubin, Hyunyoung Jeong   +4 more
doaj   +1 more source

Mechanistic studies of uridine diphosphate glucuronosyltransferase

Chemico-Biological Interactions, 1994
Bisubstrate reaction kinetics and product inhibition studies were used to characterize the kinetic mechanism of a partially purified uridine diphosphate glucuronosyltransferase (UDPGT). These studies indicate that the reaction most likely occurs via a random order sequential mechanism.
H, Yin, G, Bennett, J P, Jones
openaire   +2 more sources

The 5T Paradox of Triclosan: From Toiletries to Toxic Trash, a Growing Threat to Humanity

Environmental Toxicology, EarlyView.
ABSTRACT Triclosan (TCS) persists as a contaminant of concern in the Anthropocene, despite regulatory actions. Environmental dissemination continues through wastewater effluents, biosolid application, and improper disposal practices. This narrative review synthesizes current evidence regarding triclosan's environmental fate, transformation pathways ...
Temitope Aribigbola, Mauro Ricardo Souza da Luz, Sunday Amos Onikanni, Marjorie Dardis Murucci, Oluwatosin Stella Olayinka, Rodrigo Soares Fortunato, Rômulo Sperduto Dezonne, Omolola Esther Amos, Sara Gemini Piperni, Denise Pires de Carvalho, Leandro Miranda‐Alves   +10 more
wiley   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Perioperative Anaesthetic Management of a Patient of Gilbert’s Syndrome with Adult Congenital Heart Disease - A Rare Presentation

The Indian Anaesthetists' Forum, 2014
Gilbert's syndrome is a hereditary condition with the genetic mutation of the enzyme uridine diphosphate glucuronosyltransferase, characterized by intermittent jaundice in the absence of hemolysis or underlying liver disease.
Sambhunath Das, Neelam Agarwal
doaj  

Is Ceftriaxone-Induced Biliary Pseudolithiasis Influenced by UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms?

Case Reports in Medicine, 2011
Ceftriaxone (cfx), a third-generation cephalosporin antibiotic, leads to transient cholelithiasis in some children, also known as pseudolithiasis. However, the underlying pathogenetic mechanism of this adverse effect has not yet been elucidated.
Andrew Fretzayas, Olga Liapi, Anna Papadopoulou, Polyxeni Nicolaidou, Alexandra Stamoulakatou   +4 more
doaj   +1 more source

Transcriptional responses of Aedes aegypti chemosensory tissues in response to volatile DEET and citronella oil

Insect Molecular Biology, EarlyView.
Aedes aegypti females were significantly repelled by both volatile DEET and citronella oil in comparison to control (ethanol‐exposed) mosquitoes. Global gene expression changes were largest in the mosquito mouthparts, with notable downregulation of the three subunits comprising the mosquito CO2 receptor (Gr1, 2 and 3).
Ivan Drahun, Jessica M. Sparrow, Cody W. Koloski, Bryan J. Cassone   +3 more
wiley   +1 more source