Results 101 to 110 of about 14,230 (233)

Transplantation of Gunn rats with autologous fibroblasts expressing bilirubin UDP-glucuronosyltransferase: correction of genetic deficiency and tumor formation

, 1997
The end product of the breakdown of the heme group of hemoglobin and other heme-containing proteins is bilirubin. Bilirubin is hydrophobic and cannot be excreted as such. Therefore, mammals have a liver enzyme bilirubin UDP-glucuronosyltransferase (B-UGT)
Ottenhoff, R., Sengupta, K., Chowdhury, J. R., Oude Elferink, R. P., Seppen, J., Chowdhury, N. R., Bosma, P. J., Tada, K.   +7 more
core   +1 more source

Clinical and molecular study of Egyptian pediatric patients with Crigler-Najjar syndrome

Egyptian Liver Journal
Background Crigler-Najjar syndrome (CNS) is a rare autosomal recessive inherited disorder caused by uridine diphosphate-glucuronosyltransferase (UGT) enzyme deficiency. The enzyme is encoded by the uridine diphosphate-glucuronosyltransferase 1A1 (UGT1A1)
Mohammed A. Khedr, Behairy E. Behairy, Hosam El Din M. Basiouny, Nora A. Zeitoon, Ashraf Yousif Elfert, Haidy Mohammed Zakaria, Tamer H. A. Ammar   +6 more
doaj   +1 more source

Morphine glucuronosyltransferase activity in human liver microsomes is inhibited by a variety of drugs that are co-administered with morphine.

, 2007
Morphine is an analgesic drug used for the treatment of acute and chronic pain syndromes for cancer patients. Glucuronidation is a major pathway of the elimination of morphine in humans.
Yokoi, Tsuyoshi, 横井, 毅, 70266162, 109891, 宮本, 謙一, 22059, 70135226, Miyamoto, Ken-ichi, 196, 原, 祐輔, Hara, Yusuke, 中嶋, 美紀, 30100514, 63, Nakajima, Miki   +14 more
core   +1 more source

The Survival and Physiological Response of Calliptamus abbreviatus Ikonn (Orthoptera: Acrididae) to Flavonoids Rutin and Quercetin

Insects
Insect-resistant substances from plants are important natural resources that human beings can potentially develop and use to control pests. In this study, we explored the adverse effects of rutin and quercetin on grasshopper (Calliptamus abbreviatus), as
Xunbing Huang, Li Zheng, Yueyue Wang
doaj   +1 more source

Opposite regulation of bilirubin and 4-nitrophenol UDP-glucuronosyltransferase mRNA levels by 3,3′,5 triiodo-l-thyronine in rat liver

, 1996
The effects of 3,3′,5 triiodo-l-thyronine (L-T3) on the constitutive levels of hepatic mRNA encoding two UDP-glucuronosyltransferase (UGT) isoforms implicated in the glucuronidation of planar phenolic substrates (UGTI∗06) and bilirubin (UGT1∗0) were ...
Yves Artur, Jacques Mounié, Magdalou, Jacques, Goudonnet, Hervé, Artur, Yves, Mounié, Jacques, Masmoudi, Taoufik, Jacques Magdalou, Taoufik Masmoudi, Hervé Goudonnet, Planells, Richard, Richard Planells   +11 more
core   +1 more source

Tapentadol withdrawal, a newer trend in opioid overuse in Nepal: A case report

Journal of Nepal Health Research Council
Crigler–Najjar Syndrome Type 2 (CNS2) is a rare autosomal recessive disorder characterized by unconjugated hyperbilirubinemia due to partial deficiency of the enzyme uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1).
Hemant Chand, Om Prakash Bhatta, Sabita Chand, Neha Dangol, Sachin Awasthi, Ram Chandra Poudel, Ram Prasad Lamichhane   +6 more
doaj   +1 more source

A β-glucuronosyltransferase from Arabidopsis thaliana involved in biosynthesis of type II arabinogalactan has a role in cell elongation during seedling growth

, 2013
We have characterized a β-glucuronosyltransferase (AtGlcAT14A) from Arabidopsis thaliana that is involved in the biosynthesis of type II arabinogalactan (AG).
Knoch, Eva, Poulsen, Christian Peter, Geshi, Naomi, Kotake, Toshihisa, Ulvskov, Peter, Tryfona, Theodora, Xiong, Guangyan, Poulsen, Christian P, Dilokpimol, Adiphol; id_orcid, Harholt, Jesper, Tsumuraya, Yoichi, Hadi, Masood Z., Dupree, Paul, Petersen, Bent L, Pauly, Markus, Hadi, Masood Z, Dilokpimol, Adiphol   +16 more
core   +1 more source

Applied physiologically‐based pharmacokinetic modeling to assess uridine diphosphate‐glucuronosyltransferase‐mediated drug–drug interactions for Vericiguat

CPT: Pharmacometrics & Systems Pharmacology
Vericiguat (Verquvo; US: Merck, other countries: Bayer) is a novel drug for the treatment of chronic heart failure. Preclinical studies have demonstrated that the primary route of metabolism for vericiguat is glucuronidation, mainly catalyzed by uridine ...
Sebastian Frechen, Ibrahim Ince, André Dallmann, Michael Gerisch, Natalia A. Jungmann, Corina Becker, Maximilian Lobmeyer, Maria E. Trujillo, Shiyao Xu, Rolf Burghaus, Michaela Meyer   +10 more
doaj   +1 more source

EFFECT OF URIDINE DIPHOSPHATE-GLUCURONOSYLTRANSFERASE POLYMORPHISMS ON THE PLASMA CONCENTRATIONS OF MYCOPHENOLIC ACID IN TURKISH RENAL TRANSPLANT PATIENTS

, 2017
Objective: The pharmacokinetics of mycophenolic acid (MPA) differ among individuals. MPA is primarily metabolized by uridine diphosphate-glucuronosyltransferase (UGT), and UGT2B7 is an important UGT for the glucuronidation of MPA.
Senturk Ciftci, HAYRİYE, Savran Oguz, Fatma, Tefik, Tzevat, Demir, Erol, Turkmen, Aydin, Nane, Ismet, Savran Karadeniz, Meltem   +6 more
core  

Is capillary electrophoresis on microchip devices able to genotype uridine diphosphate glucuronosyltransferase 1A1 TATA-box polymorphisms?

, 2014
In this commentary, we focused our attention on capillary electrophoresis. It achieves the efficient separation of molecular species by the application of high voltages to samples in solution.
Canu, Giulia, De Bonis, Maria, Minucci, Angelo, Capoluongo, Ettore Domenico   +3 more
core   +1 more source