Results 111 to 120 of about 30,656 (311)
Journal of Clinical Investigation, 1998 Irinotecan (CPT-11) is a promising antitumor agent, recently approved for use in patients with metastatic colorectal cancer. Its active metabolite, SN-38, is glucuronidated by hepatic uridine diphosphate glucuronosyltransferases (UGTs).
L. Iyer +7 more
semanticscholar +1 more source
Clinical Pharmacology &Therapeutics, Volume 117, Issue 6, Page 1732-1742, June 2025.Clinical cocktails for cytochrome P450 (CYP) phenotyping lack a marker for CYP2C8. We aimed to combine the CYP2C8 index drug repaglinide with the Geneva cocktail (caffeine/CYP1A2, bupropion/CYP2B6, flurbiprofen/CYP2C9, omeprazole/CYP2C19, dextromethorphan/CYP2D6, and midazolam/CYP3A4). We also included endogenous organic anion transporting polypeptide (
Laura Aurinsalo +7 more
wiley +1 more source
Pharmaceutics, 2011 Antiretrovirals are prone to drug-drug and drug-food interactions that can result in subtherapeutic or supratherapeutic concentrations. Interactions between antiretrovirals and medications for other diseases are common due to shared metabolism through ...
R. Chris Rathbun, Michelle D. Liedtke
doaj +1 more source
Identification of Genetic Variants Associated with Pravastatin and Pitavastatin Pharmacokinetics
Clinical Pharmacology &Therapeutics, Volume 117, Issue 6, Page 1763-1774, June 2025.A clinical trial was carried out to investigate the pharmacogenetics of single‐dose pravastatin and pitavastatin pharmacokinetics in 173 and 164 healthy participants. Additionally, 96 participants were included from previous pharmacogenetic studies with pravastatin. In a genome‐wide meta‐analysis of pravastatin including all 269 participants, SLCO1B1 c.
Anssi J. H. Mykkänen +9 more
wiley +1 more source
Dietary moderately oxidized oil activates the Nrf2 signaling pathway in the liver of pigs
Lipids in Health and Disease, 2012 Background Previous studies have shown that administration of oxidized oils increases gene expression and activities of various enzymes involved in xenobiotic metabolism and stress response in the liver of rats and guinea pigs.
Varady Juliane +4 more
doaj +1 more source
Demonstration of functional heterogeneity of hepatic uridine diphosphate glucuronosyltransferase activities after administration of 3-methylcholanthrene and phenobarbital to rats [PDF]
, 1978 G. J. Wishart
openalex +1 more source
Food Science &Nutrition, Volume 13, Issue 6, June 2025.Betonica macrantha methanol extract exhibited anticancer activity against MDA‐MB‐231 breast cancer cells (IC50: 0.8 mg/mL), upregulating miR‐19, miR‐20a, miR‐126, and miR‐200c. GC–MS and HPLC analyses identified key bioactive compounds, including α‐pinene, caryophyllene, and catechin, which showed favorable pharmacokinetics and target interactions ...
Muhammed Emin Sarı +6 more
wiley +1 more source
Análise do polimorfismo TA6/TA7 na região promotora do gene UGT1A1, em pacientes com anemia e traço falciforme de dois hospitais da cidade de Porto Alegre – RS [PDF]
, 2011 A doença de células falciformes é uma anemia hemolítica crônica de caráter autossômico recessivo, causada por uma mutação pontual no cromossomo 11. Esta mutação provoca a substituição de um ácido glutâmico por uma valina na posição seis da cadeia da ...
Antunes, Liana
core
Regulation of onset of development of UDP-glucuronosyltransferase activity towards o-aminophenol by glucocorticoids in late-foetal rat liver in utero [PDF]
, 1977 G. J. Wishart, Geoffrey J. Dutton
openalex +1 more source
Acta Medica Iranica, 2013 To determine the association between polymorphism of UGT1A1 gene and idiopathic hyperbilirubinemia in Iranian neonates. Fifty neonates with idiopathic hyperbilirubinemia and Serum total bilirubin (STB) more that 15mg/dl and 50 neonates with idiopathic ...
Mahbod Kaveh +5 more
doaj