Results 171 to 180 of about 14,230 (233)

UDP-Glucuronosyltransferases

Current Drug Metabolism, 2000
Glucuronidation represents a major pathway which enhances the elimination of many lipophilic xenobiotics and endobiotics to more water-soluble compounds. The UDP-glucuronosyltransferase (UGT) family catalyzes the glucuronidation of the glycosyl group of a nucleotide sugar to an acceptor compound (aglycone) at a nucleophilic functional group of oxygen ...
C D, King, G R, Rios, M D, Green, T R, Tephly   +3 more
openaire   +2 more sources

Steroid UDP glucuronosyltransferases

The Journal of Steroid Biochemistry and Molecular Biology, 1992
The glucuronidation of steroids is a major process necessary for their elimination in the bile and urine. In general, steroid glucuronides are biologically less reactive than their parent steroids. However, in some cases often associated with disease and steroid therapy, more reactive or toxic glucuronides may be formed.
P I, Mackenzie, L, Rodbourne, S, Stranks
openaire   +2 more sources

Regulation of UDP Glucuronosyltransferase Genes

Current Drug Metabolism, 2003
The UDP glucuronosyltransferase (UGT) content of cells and tissues is a major determinant of our response to those chemicals that are primarily eliminated by conjugation with glucuronic acid. There are marked interindividual differences in the content of UGTs in the liver and other organs.
Nishiyama, Takahito, Xie, Wen, Gregory, Philip A, Lewinsky, Rikke Holm, Jorgensen, Bo R, Mackenzie, Peter Ian, Gardner-Stephen, Dione Anne, Radominska-Pandya, A   +7 more
openaire   +3 more sources

The UDP-Glucuronosyltransferases as Oligomeric Enzymes

Current Drug Metabolism, 2008
The UDP-glucuronosyltransferases (UGTs) are integral membrane proteins of the endoplasmic reticulum that play important roles in the defense against potentially hazardous xenobiotics. The UGTs also participate in the metabolism and homeostasis of many endogenous compounds, including bilirubin and steroid hormones.
Moshe, Finel, Mika, Kurkela
openaire   +2 more sources

UDP-Glucuronosyltransferase in gilbert’s syndrome

Pathology, 1996
The diagnosis of Gilbert's syndrome, a condition characterised by mild jaundice related to chronic unconjugated hyperbilirubinemia, is often presumptive and the pathogenesis is incompletely understood. It would be of interest to develop an immunohistochemical staining method to confirm a diagnosis of Gilbert's syndrome.
H S, Debinski, C S, Lee, A P, Dhillon, P, Mackenzie, J, Rhode, P V, Desmond   +5 more
openaire   +2 more sources

Heterodimerization of Human UDP-Glucuronosyltransferase 1A9 and UDP-Glucuronosyltransferase 2B7 Alters Their Glucuronidation Activities

Drug Metabolism and Disposition, 2023
Human UDP-glucuronosyltransferases (UGTs) play a pivotal role as prominent phase II metabolic enzymes, mediating the glucuronidation of both endobiotics and xenobiotics. Dimerization greatly modulates the enzymatic activities of UGTs. In this study, we examined the influence of three mutations (H35A, H268Y, and N68A/N315A) and four truncations (signal ...
Jia Xue, Jiayi Yin, Jing Nie, Huidi Jiang, Haitao Zhang, Su Zeng   +5 more
openaire   +2 more sources

Human UDP-Glucuronosyltransferase 2B7

Current Drug Metabolism, 2001
UDP-Glucuronosyltransferases (UGTs) are glycoproteins, localized in endoplasmic reticulum (ER) and nuclear membranes, which catalyze the confugation of a broad variety of lipophilic aglycon substrates with glucuronic acid using UDP-glucuronic acid (UDP-GlcUA) as the sugar donor.
A, Radominska-Pandya, J M, Little, P J, Czernik   +2 more
openaire   +2 more sources

Mechanistic studies of uridine diphosphate glucuronosyltransferase

Chemico-Biological Interactions, 1994
Bisubstrate reaction kinetics and product inhibition studies were used to characterize the kinetic mechanism of a partially purified uridine diphosphate glucuronosyltransferase (UDPGT). These studies indicate that the reaction most likely occurs via a random order sequential mechanism.
Jeffrey P Jones
exaly   +3 more sources

UDP-Glucuronosyltransferases*

2010
United ...
Mackenzie, Peter Ian, Gardner-Stephen, Dione Anne, Miners, John Oliver   +2 more
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Regulation of Mammalian UDP-Glucuronosyltransferases

Current Drug Metabolism, 2018
UDP-glucuronosyltransferases (UGTs) are a class of important phase II drug metabolizing enzymes (DMEs), playing essential roles in the homeostasis of endobiotics as well as the dispositional behavior of exogenous compounds. The expression and enzyme activity of UGTs are regulated by multiple dimensions of mechanisms and can be influenced by diverse ...
Hong, Wang, Guoxiu, Cao, Guangji, Wang, Haiping, Hao   +3 more
openaire   +2 more sources