Results 181 to 190 of about 14,230 (233)
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Immobilized glucuronosyltransferase for the synthesis of conjugates
Journal of Medicinal Chemistry, 1976Partially purified rabbit liver UDPglucuronosyltransferase is immobilized on agarose by the cyanogen bromide activation method. Both soluble and matrix-bound enzyme preparations display very similar Km and pH optimum. The storage stability of the immobilized enzyme at 4 degrees is 5-10 times improved over the soluble preparations.
I, Parikh, D W, MacGlashan, C, Fenselau
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Uridine diphosphate glucuronosyltransferase 1A1
Xenobiotica, 2019The role that the phase-II reaction, glucuronidation, plays in the biotransformation of endo and xenobiotics is discussed with particular emphasis given to the UGT1A1 isoenzyme. This individual isoenzyme is responsible for both the mono and di-glucuronidation of bilirubin together with the glucuronidation of a number of xenobiotics of clinical interest
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Structure of UDPâGlucuronosyltransferases in Membranes
2005This chapter presents the most recent experimental approaches to the investigation of UDP-glucuronosyltransferase (UGTs) in membranes. The first topic described is the subcellular localization of UGTs with special emphasis on the association of these proteins with the endoplasmic reticulum (ER).
Anna, Radominska-Pandya +3 more
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Inhibition of aflatoxins on UDP-glucuronosyltransferases (UGTs)
Toxicology in Vitro, 2023Aflatoxins have been recognized as the most harmful mycotoxins leading to various toxic effects. The present study aims to determine the inhibition behavior of aflatoxins on the activity of the important phase II metabolizing enzymes, UDP-glucuronosyltransferases (UGTs), based on in vitro incubation system of recombinant human UGTs-catalyzed ...
Zuo, Du, Zhen-Zhong, Liu
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Isolation and purification of UDP-glucuronosyltransferases
Chemical Research in Toxicology, 1990UDPGTs are members of a class of enzymes located in the endoplasmic reticulum and are encoded by a multigene family. These proteins are responsible for the glucuronidation of hundreds of xenobiotics of many chemical classes and many endogenous substances such as steroid hormones, bile acids, and bilirubin.
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Posttranscriptional regulation of uridine diphosphate glucuronosyltransferases
Expert Opinion on Drug Metabolism & Toxicology, 2015The uridine diphosphate (UDP)-glucuronosyltransferase (UGT) superfamily of enzymes (EC 2.4.1.17) conjugates glucuronic acid to an aglycone substrate to make them more polar and readily excreted. In general, this reaction terminates the activities of chemicals, drugs and toxins, although occasionally a more active or toxic species is produced.In ...
Zoe, Riches, Abby C, Collier
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Polymorphism of UDP-Glucuronosyltransferase and Drug Metabolism
Current Drug Metabolism, 2005UDP-glucuronosyltransferase is a group of catabolic enzymes involved in the detoxification and excretion of many xenobiotic and endogeneous substances in intrahepatic and extrahepatic tissues. The group consists of two subfamilies, UGT1 and UGT2. UGT1 consists of 5 exons and has a unique gene structure.
Yoshihiro, Maruo +4 more
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Coffee and Gastrointestinal Glucuronosyltransferases
2015Abstract The beneficial health effects of coffee have, among other mechanisms, been linked to the activation of phase II enzymes, including UDP-glucuronosyltransferases (UGTs). UGTs catalyze the detoxification of many xenobiotic compounds, including human carcinogens and reactive oxygen species.
Christian P. Strassburg, Sandra Kalthoff
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STRUCTURE AND FUNCTION OF URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASES
Clinical and Experimental Pharmacology and Physiology, 1997SUMMARY1. The uridine diphosphate (UDP)âglucuronosyltransferases (UGT) are a family of enzymes that catalyse the covalent addition of glucuronic acid to a wide range of lipophilic chemicals. They play a major role in the detoxification of many exogenous and endogenous compounds by generating products that are more polar and, thus, more readily excreted
R, Meech, P I, Mackenzie
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Ontogenesis of UDP-glucuronosyltransferase enzymes in sheep
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2011UDP glucuronosyltransferases (UGTs) are important for the metabolism of many drugs. To understand the ontogeny of these enzymes in sheep (Ovis aries), knowledge of their expression levels at different developmental stages is important. cDNA sequences of six UGTs (UGT1A1, UGT1A3, UGT1A4, UGT1A6 and UGT1A9) were cloned in sheep liver by rapid ...
Manoja, Pretheeban +4 more
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