Results 191 to 200 of about 14,230 (233)
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Natural and synthetic inhibitors of UDP-glucuronosyltransferase
Pharmacology & Therapeutics, 2001Glucuronidation is a major detoxification pathway in vertebrates. The reaction is catalyzed by a family of UDP-glucuronosyltransferases (UGTs) and involves conjugation of many endobiotic and xenobiotic substances with glucuronic acid, forming inactive water-soluble glucuronides.
K, Grancharov +3 more
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Development of Human Liver UDP-Glucuronosyltransferases
Developmental Pharmacology and Therapeutics, 2017The development of multiple UDPGT activities towards eight substrates has been studied in fetal term and adult post-mortem (less than 5 h after death) liver samples. Most fetal and term liver activities were less than 14% of adult values, except that towards 5-hydroxytryptamine which was present in fetal and term liver at adult levels.
B, Burchell +6 more
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UDP-glucuronosyltransferases: a family of detoxifying enzymes
Trends in Pharmacological Sciences, 1990Glucuronidation is an important process in the metabolism of xenobiotic and endogenous substances leading to enhancement of excretion of these compounds from the body. A multigene family encodes a number of UDP-glucuronosyltransferase enzymes which catalyse this route of metabolism.
T R, Tephly, B, Burchell
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Regulation of UDP glucuronosyltransferases in the gastrointestinal tract
Toxicology and Applied Pharmacology, 2004The UDP glucuronosyltransferases (UGT) of the gastrointestinal (GI) tract have a crucial role in protection against the toxic effects of lipophilic chemicals in the environment. UGTs such as UGT1A7, UGT1A8, and UGT1A10 are exclusively expressed in gastrointestinal tissues, each with a unique tissue distribution pattern that is subject to ...
Gregory, Philip A +3 more
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UDP-Glucuronosyltransferase inhibitors
European Journal of Drug Metabolism and Pharmacokinetics, 1998E, Golovinsky +2 more
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