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Posttranscriptional regulation of uridine diphosphate glucuronosyltransferases
Expert Opinion on Drug Metabolism & Toxicology, 2015The uridine diphosphate (UDP)-glucuronosyltransferase (UGT) superfamily of enzymes (EC 2.4.1.17) conjugates glucuronic acid to an aglycone substrate to make them more polar and readily excreted. In general, this reaction terminates the activities of chemicals, drugs and toxins, although occasionally a more active or toxic species is produced.In ...
Zoe, Riches, Abby C, Collier
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The UDP-Glucuronosyltransferases as Oligomeric Enzymes
Current Drug Metabolism, 2008The UDP-glucuronosyltransferases (UGTs) are integral membrane proteins of the endoplasmic reticulum that play important roles in the defense against potentially hazardous xenobiotics. The UGTs also participate in the metabolism and homeostasis of many endogenous compounds, including bilirubin and steroid hormones.
Moshe, Finel, Mika, Kurkela
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UDP-glucuronosyltransferases in human intestinal mucosa
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1998While UDP-glucuronosyltransferases (UGTs) are known to be expressed at high levels in human liver, relatively little is known about extrahepatic expression. In the present study, UGT2B family isoforms involved in the glucuronidation of steroid hormones and bile acids have been characterized in microsomes prepared from jejunum, ileum and colon from six ...
A, Radominska-Pandya +6 more
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Coffee and Gastrointestinal Glucuronosyltransferases
2015Abstract The beneficial health effects of coffee have, among other mechanisms, been linked to the activation of phase II enzymes, including UDP-glucuronosyltransferases (UGTs). UGTs catalyze the detoxification of many xenobiotic compounds, including human carcinogens and reactive oxygen species.
Christian P. Strassburg, Sandra Kalthoff
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UDP-Glucuronosyltransferase inhibitors
European Journal of Drug Metabolism and Pharmacokinetics, 1998E, Golovinsky +2 more
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Isolation and purification of UDP-glucuronosyltransferases
Chemical Research in Toxicology, 1990UDPGTs are members of a class of enzymes located in the endoplasmic reticulum and are encoded by a multigene family. These proteins are responsible for the glucuronidation of hundreds of xenobiotics of many chemical classes and many endogenous substances such as steroid hormones, bile acids, and bilirubin.
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UDP-glucuronosyltransferase activities
Biochemical Pharmacology, 1983Karl Walter Bock +7 more
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