Results 51 to 60 of about 30,656 (311)

Relation between Neonatal Icter and Gilbert Syndrome in Gloucose-6-Phosphate Dehydrogenase Deficient Subjects [PDF]

Journal of Clinical and Diagnostic Research, 2014
Background and Aim: The pathogenesis of neonatal hyperbilirubinemia hasn’t been completely defined in Gloucose-6Phosphate Dehydrogenase (G6PD) deficient newborns.
Yadollah Zahedpasha, Mousa Ahmadpour, Haleh Akhavan Niaki, Ehsan Alaee   +3 more
doaj   +1 more source

β‐Glucuronidase‐Expressing Lactobacillus reuteri Triggers Irinotecan Enterotoxicity Through Depleting the Regenerative Epithelial Stem/Progenitor Pool

Advanced Science, EarlyView.
XLP mitigated CPT11 mucositis by suppressing GUS‐expressing microbes, notably L. reuteri, and diminishing bacterial GUS activity, consequently reducing SN38 accumulation to protect the intestinal epithelium. This preservation of the mucosal stem cell niche enabled rapid regeneration of secretory lineages such as mucin‐producing goblet cells, which ...
Bei Yue, Ruiyang Gao, Ling Zhao, Donghui Liu, Cheng Lv, Ziyi Wang, Fangbin Ai, Beibei Zhang, Zhilun Yu, Xiaolong Geng, Hao Wang, Kang Wang, Kaixian Chen, Chenghai Liu, Zhengtao Wang, Wei Dou   +15 more
wiley   +1 more source

Successful Pregnancy Outcome In Maternal Crigler Najjar Syndrome Type II. [PDF]

, 2012
Estimated incidence of Crigler-Najjar syndrome(CNS) is 1 case per 1,000,000 births(1 million). The overall prevalence of CN syndrome is unknown, with only several hundred people reported to have this disease.
Padmalatha, VV, Poornima, M, Rao, SR, Shakuntala, PN   +3 more
core  

A Network-Based Pharmacology Study of the Herb-Induced Liver Injury Potential of Traditional Hepatoprotective Chinese Herbal Medicines [PDF]

, 2017
published_or_final_versio
Cheung, F, Feng, Y, HONG, M, Huang, J, LI, S, Tan, HY, Wang, N   +6 more
core   +1 more source

Variability in intestinal drug metabolizing enzymes and transporters in Crohn's disease and potential impact on oral drug absorption

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of study was to generate quantitative data on the abundance of drug‐metabolizing enzymes and transporters (DMETs) in inflamed and non‐inflamed Crohn's disease (CD) ileum and colon, for incorporation into physiologically based pharmacokinetic (PBPK) models, enabling prediction of oral drugs' pharmacokinetics (PK) perturbation in CD patients.
Sarah Alrubia, Brahim Achour, Zubida M. Al‐Majdoub, Amin Rostami‐Hodjegan, Jill Barber   +4 more
wiley   +1 more source

Recombinant expression and functional characterisation of regiospecific flavonoid glucosyltransferases from Hieracium pilosella L. [PDF]

, 2009
Five glucosyltransferases were cloned by RT-PCR amplification using total RNA from Hieracium pilosella L. (Asteraceae) inflorescences as template. Expression was accomplished in Escherichia coli, and three of the HIS-tagged enzymes, UGT90A7, UGT95A1, and
Martens, S., Matern, U., Moco, S.I.A., Vervoort, J.J.M., Witte, S.   +4 more
core   +2 more sources

Inhibitory Effect of Sauchinone on UDP-Glucuronosyltransferase (UGT) 2B7 Activity

Molecules, 2018
Herb–drug interaction (HDI) limits clinical application of herbs and drugs, and inhibition of herbs towards uridine diphosphate (UDP)-glucuronosyltransferases (UGTs) has gained attention as one of the important reasons to cause HDIs.
Byoung Hoon You, Eun Chae Gong, Young Hee Choi   +2 more
doaj   +1 more source

Pharmacokinetics and pharmacodynamics of empagliflozin in paediatric patients aged 10–17 years with type 2 diabetes mellitus

British Journal of Clinical Pharmacology, EarlyView.
Aims To characterize the pharmacokinetics (PK) and PK/pharmacodynamics (PD) regarding glycosylated haemoglobin (HbA1c) lowering using the paediatric data from DINAMO and to assess differences compared with adults. Methods Population PK and PK/PD models previously developed for empagliflozin in adults and adolescents were re‐estimated in a Bayesian ...
Juliane Rascher, Shen Cheng, Curtis Johnston, Sebastian Härtter, Wojtyniak Jan‐Georg, Jan Marquard, Igor Tartakovsky, Lori M. B. Laffel   +7 more
wiley   +1 more source

Bilirubin dependent on UGT1A1 polymorphisms, hemoglobin, fasting time and body mass index [PDF]

, 2011
In PressIn humans, bilirubin levels are influenced by different factors. This study aims to evaluate the influence of several nongenetic factors (hematologic data, smoking status, alcohol intake, fasting time, physical activity, oral contraceptive ...
Bronze-da-Rocha, Elsa, Carvalho, João, Costa, Elísio, Rocha-Pereira, Petronila, Rodrigues, Carina, Santos, Rosário, Santos-Silva, Alice, Vieira, Emília   +7 more
core   +1 more source

Effect of the genetic mutant G71R in uridine diphosphate-glucuronosyltransferase 1A1 on the conjugation of bilirubin

Open Life Sciences, 2022
We aimed to investigate the effect of the genetic mutant G71R (c. 211G > A) in uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1) on the glucuronidation of unconjugated bilirubin.
Chen Hong, Zhong Danni, Gao Zongyan, Wu Xiaojing   +3 more
doaj   +1 more source