Results 81 to 90 of about 25,858 (256)
17β-Estradiol up-regulates UDP-glucuronosyltransferase 1A9 expression via estrogen receptor α
Acta Pharmaceutica Sinica B, 2016 UDP-glucuronosyltransferase 1A9 (UGT1A9) is a major phase II enzyme responsible for elimination of drugs and endogenous molecules. Clinical data have shown increased elimination of UGT1A9 substrates in pregnant women or oral contraceptive users, but the ...
Sung-joon Cho +4 more
doaj +1 more source
Mechanistic studies of uridine diphosphate glucuronosyltransferase
Chemico-Biological Interactions, 1994 Bisubstrate reaction kinetics and product inhibition studies were used to characterize the kinetic mechanism of a partially purified uridine diphosphate glucuronosyltransferase (UDPGT). These studies indicate that the reaction most likely occurs via a random order sequential mechanism.
H, Yin, G, Bennett, J P, Jones
openaire +2 more sources
Chemoprevention of aberrant crypt foci in the colon of rats by dietary onion [PDF]
, 2007 Onion intake might reduce the risk of colorectal cancer, according to epidemiology. However, Femia showed in 2003 that diets with a 20% onion intake increase carcinogenesis in rats. We speculated this dose was too high.
Corpet, Denis E. +2 more
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Impact of UGT1A1 gene variants on total bilirubin levels in Gilbert syndrome patients and in healthy subjects [PDF]
, 2012 A significant different allelic distribution, in Gilbert patients and in controls, was found for two promoter polymorphisms. Among patients, 82.2% were homozygous and 17.8% heterozygous for the c.− 41_ − 40dupTA allele; in control group, 9.9% were ...
Bronze-da-Rocha, Elsa +6 more
core +3 more sources
Case Reports in Medicine, 2011 Ceftriaxone (cfx), a third-generation cephalosporin antibiotic, leads to transient cholelithiasis in some children, also known as pseudolithiasis. However, the underlying pathogenetic mechanism of this adverse effect has not yet been elucidated.
Andrew Fretzayas +4 more
doaj +1 more source
Pharmaceutics, 2011 Antiretrovirals are prone to drug-drug and drug-food interactions that can result in subtherapeutic or supratherapeutic concentrations. Interactions between antiretrovirals and medications for other diseases are common due to shared metabolism through ...
R. Chris Rathbun, Michelle D. Liedtke
doaj +1 more source
The Indian Anaesthetists' Forum, 2014 Gilbert's syndrome is a hereditary condition with the genetic mutation of the enzyme uridine diphosphate glucuronosyltransferase, characterized by intermittent jaundice in the absence of hemolysis or underlying liver disease.
Sambhunath Das, Neelam Agarwal
doaj
Dietary moderately oxidized oil activates the Nrf2 signaling pathway in the liver of pigs
Lipids in Health and Disease, 2012 Background Previous studies have shown that administration of oxidized oils increases gene expression and activities of various enzymes involved in xenobiotic metabolism and stress response in the liver of rats and guinea pigs.
Varady Juliane +4 more
doaj +1 more source
SAFETY EVALUATION OF STATIN IN YOGYAKARTA, INDONESIA [PDF]
, 2009 Background : The 3-hydroxy-3-methylglutaryl-coenzyme (HMG-Co-A) reductase inhibitors, also known as statins, are the most effective class of drugs for lowering serum Low-Density Lipoprotein cholesterol (LDL-c)concentrations.
Anni, Anni +3 more
core
Topoisomerase 1 Promoter Variants and Benefit from Irinotecan in Metastatic Colorectal Cancer Patients [PDF]
, 2016 Objective: Topoisomerase 1 (topo-1) is an important target for the treatment of metastatic colorectal cancer (CRC). The aim of the present study was to evaluate the correlation between topo-1 single-nucleotide polymorphisms (SNPs) and clinical outcome in
Crea, F. +11 more
core +1 more source