Results 91 to 100 of about 17,873 (207)
Modeling PROTAC Degradation Activity with Machine Learning [PDF]
Artificial Intelligence in the Life Sciences, Volume 6, 2024,
100104PROTACs are a promising therapeutic modality that harnesses the cell's built-in degradation machinery to degrade specific proteins. Despite their potential, developing new PROTACs is challenging and requires significant domain expertise, time, and cost. Meanwhile, machine learning has transformed drug design and development.
arxiv +1 more source
Standard Protocols for Characterising Primary and In Vitro‐Generated Human Hepatocytes
Journal of Cellular and Molecular Medicine, Volume 29, Issue 3, February 2025.ABSTRACT Hepatocyte‐like cells (HLCs) derived from pluripotent stem cells (PSCs) or direct reprogramming are an unlimited source of human hepatocytes for biomedical applications. HLCs are used to model human diseases, develop precise drugs and establish groundbreaking regenerative cell‐based therapies.
Zahra Heydari +11 more
wiley +1 more source
Plant Biotechnology Journal, Volume 23, Issue 2, Page 592-614, February 2025.Summary Pigments, as coloured secondary metabolites, endow the world with a rich palette of colours. They primarily originate from plants and microorganisms and play crucial roles in their survival and adaptation processes. In this article, we categorize pigments based on their chemical structure into flavonoids, carotenoids, pyrroles, quinones ...
Qian Tang +4 more
wiley +1 more source
Research advances in molecular mechanisms regulating heat tolerance in cool‐season turfgrasses
Crop Science, Volume 65, Issue 1, January/February 2025.Abstract Cool‐season turfgrasses widely used on golf courses, athletic fields, and other landscapes are environmentally and economically important, but they are functionally and aesthetically damaged under prolonged exposure to high temperatures because of their sensitivity to heat stress.
Stephanie Rossi, Bingru Huang
wiley +1 more source
Characterization of key triacylglycerol biosynthesis processes in rhodococci. [PDF]
, 2016 Oleaginous microorganisms have considerable potential for biofuel and commodity chemical production. Under nitrogen-limitation, Rhodococcus jostii RHA1 grown on benzoate, an analog of lignin depolymerization products, accumulated triacylglycerols (TAGs ...
Amara, Sawsan +5 more
core +2 more sources
Importance of glutamate synthase in glutamate synthesis by soybean cell suspension cultures.
Plant Physiology, 1979 The specific activities of glutamate synthase|EC 2.6.1.53, l-glutamine: alpha-ketoglutarate amino transferase (NADPH-oxidising)| and glutamine synthetase|EC 6.3.1.2, l-glutamate: ammonia ligase (ADP-forming)| extracted from soybean (Glycine max L.) cells
J. Chiu, P. D. Shargool
semanticscholar +1 more source
PUB-MS - a mass-spectrometry-based method to monitor protein-protein proximity in vivo [PDF]
arXiv, 2011 The common techniques to study protein-protein proximity in vivo are not well-adapted to the capabilities and the expertise of a standard proteomics laboratory, typically based on the use of mass spectrometry. With the aim of closing this gap, we have developed PUB-MS (for Proximity Utilizing Biotinylation and Mass Spectrometry), an approach to monitor
arxiv
In Vitro Model for Hepatotoxicity Studies Based on Primary Human Hepatocyte Cultivation in a Perfused 3D Bioreactor System [PDF]
, 2016 Accurate prediction of the potential hepatotoxic nature of new pharmaceuticals remains highly challenging. Therefore, novel in vitro models with improved external validity are needed to investigate hepatic metabolism and timely identify any toxicity ...
Damm, Georg +11 more
core +2 more sources
Oxidative stress: a systemic factor implicated in the pathogenesis of hepatic encephalopathy [PDF]
, 2012 Although ammonia is considered the main factor involved in the pathogenesis of hepatic encephalopathy (HE), it correlates well with the severity of HE in acute liver failure, but not in chronic liver disease.
Bosoi, Cristina R., Rose, Christopher
core +1 more source
Urinary felinine excretion in intact male cats is increased by dietary cystine [PDF]
, 2008 Felinine is a branched-chain sulfur amino acid present in the urine of certain Felidae, including domestic cats. The objective of the present study was to determine if additional cystine and/or dietary N would increase felinine and N-acetylfelinine ...
Hendriks, W.H. +4 more
core +2 more sources