Results 91 to 100 of about 41,693 (219)

Consequences of PPARα Invalidation on Glutathione Synthesis: Interactions with Dietary Fatty Acids

PPAR Research, 2011
Glutathione (GSH) derives from cysteine and plays a key role in redox status. GSH synthesis is determined mainly by cysteine availability and γ-glutamate cysteine ligase (γGCL) activity.
Najoua Guelzim, Jean-François Huneau, Véronique Mathé, Annie Quignard-Boulangé, Pascal G. Martin, Daniel Tomé, Dominique Hermier   +6 more
doaj   +1 more source

Denervation does not induce muscle atrophy through oxidative stress [PDF]

, 2017
Denervation leads to the activation of the catabolic pathways, such as the ubiquitin-proteasome and autophagy, resulting in skeletal muscle atrophy and weakness.
Adamo, Sergio, Bellezza, Ilaria, Fulle, Stefania, Greco, Emanuela, Grottelli, Silvia, Mancinelli, Rosa, Minelli, Alba, Moresi, Viviana, Morozzi, Giulio, Pigna, Eva, Rotini, Alessio   +10 more
core   +3 more sources

The relationship between polymorphisms in the glutamate cysteine ligase gene and asthma susceptibility [PDF]

Respiratory Medicine, 2007
The present study was designed to investigate an association of common -588C/T and -23G/T polymorphisms within glutamate cysteine ligase modifier subunit gene with susceptibility to bronchial asthma. A total of 435 ethnically Russian subjects were recruited in this study, including 221 patients with asthma and 214 sex and age matched healthy subjects ...
Polonikov, A.V., Ivanov, V.P., Solodilova, M.A., Khoroshaya, I.V., Kozhuhov, M.A., Panfilov, V.I.   +5 more
openaire   +2 more sources

Recombinant Monoclonal Antibodies for Detecting the Tubulin Post‐Translational Modifications Glutamylation and Lysine‐40 Acetylation

Cytoskeleton, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine‐40 (K40) on α‐tubulin (αTub‐K40ac) and glutamylation of both α‐ and β‐tubulin are two tubulin PTMs of ...
Lynne Blasius, Ezekiel C. Thomas, Erik H. Collet, Erin Jenson, Chad G. Pearson, Ryoma Ohi, Kristen J. Verhey   +6 more
wiley   +1 more source

Altered NRF2 signalling in systemic redox imbalance: Insights from non-communicable diseases

Redox Biology
The balanced activity of the cytoprotective transcription factor NRF2 is central for maintaining redox, metabolic-energetics, and proteome homeostasis, as well as for regulating inflammatory responses, among other functions.
Monika Jakubowska, Vera Marisa Costa, Wojciech Krzeptowski, Pia Pužar Dominkuš, Marlene Santos, Birsen Can Demirdöğen, Şermin Genç, Ioannis P. Trougakos, Katja M. Kanninen, Brigitte M. Winklhofer-Roob, Ian M. Copple, Antonio Cuadrado, Vita Dolžan, Christina Morgenstern   +13 more
doaj   +1 more source

Asiatic Acid Exhibits Anti-inflammatory and Antioxidant Activities against Lipopolysaccharide and d-Galactosamine-Induced Fulminant Hepatic Failure

Frontiers in Immunology, 2017
Inflammation and oxidative stress are essential for the pathogenesis of fulminant hepatic failure (FHF). Asiatic acid (AA), which is a pentacyclic triterpene that widely occurs in various vegetables and fruits, has been reported to possess antioxidant ...
Hongming Lv, Hongming Lv, Zhimin Qi, Zhimin Qi, Sisi Wang, Haihua Feng, Haihua Feng, Xuming Deng, Xuming Deng, Xinxin Ci   +9 more
doaj   +1 more source

Thiol-Based Regulation of Redox-Active Glutamate-Cysteine Ligase from Arabidopsis thaliana [PDF]

The Plant Cell, 2007
Glutathione biosynthesis is a key component in the network of plant stress responses that counteract oxidative damage and maintain intracellular redox environment. Using a combination of mass spectrometry and site-directed mutagenesis, we examined the response of Arabidopsis thaliana glutamate-cysteine ligase (GCL) to changes in redox environment. Mass
Leslie M, Hicks, Rebecca E, Cahoon, Eric R, Bonner, Rebecca S, Rivard, Jeanne, Sheffield, Joseph M, Jez   +5 more
openaire   +2 more sources

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

The Protective Effect of Hispidin against Hydrogen Peroxide-Induced Oxidative Stress in ARPE-19 Cells via Nrf2 Signaling Pathway

Biomolecules, 2019
Hispidin, a polyphenol compound isolated from Phellinus linteus, has been reported to possess antioxidant activities. In this study, we aimed to investigate the mechanisms underlying the protective effect of hispidin against hydrogen peroxide (H2O2 ...
Sung-Ying Huang, Shu-Fang Chang, Siu-Fung Chau, Sheng-Chun Chiu   +3 more
doaj   +1 more source

In silico modeling and evaluation of Gordonia alkanivorans for biodesulfurization [PDF]

, 2013
10.1039/c3mb70132hMolecular BioSystems92530 ...
Aggarwal, Shilpi, Ivan, Gregorius Reinaldi, Karimi, I. A.   +2 more
core   +1 more source