Results 71 to 80 of about 41,955 (229)

Sodium hydrosulfide increases glutathione synthesis in cardiac muscle cell line HL-1 under hyperglycemia and hyperlipidemia [PDF]

Jichu yixue yu linchuang
Objective To investigate sodium hydrogen sulfide(NaHS) with function of regulating glutathione(GSH) synthesis to reduce reactive oxygen species(ROS) production in type 2 diabetic cardiomyopathy (DCM).
ZHANG Weicai, LIU Siren, WANG Shangnong
doaj   +1 more source

Redox regulation of enzymes involved in sulfate assimilation and in the synthesis of sulfur-containing amino acids and glutathione in plants

Frontiers in Plant Science, 2022
Sulfur is essential in plants because of its presence in numerous molecules including the two amino acids, cysteine, and methionine. Cysteine serves also for the synthesis of glutathione and provides sulfur to many other molecules including protein ...
Linda de Bont, Natacha Donnay, Jérémy Couturier, Jérémy Couturier, Nicolas Rouhier   +4 more
doaj   +1 more source

Plasmids in the aphid endosymbiont Buchnera aphidicola with the smallest genomes. A puzzling evolutionary story.

, 2006
Buchnera aphidicola, the primary endosymbiont of aphids, has undergone important genomic and biochemical changes as an adaptation to intracellular life.
Gil, Rosario, Latorre, Amparo, Perez-Brocal, Vicente, Sabater-Muñoz, Beatriz, Silva, Francisco J   +4 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer [PDF]

, 2018
During tumorigenesis, the high metabolic demand of cancer cells results in increased production of reactive oxygen species. To maintain oxidative homeostasis, tumor cells increase their antioxidant production through hyperactivation of the NRF2 pathway ...
Altman, Biancur, Boulahbel, Briggs, Cairns, Cancer Genome Atlas Research Network, Chandel, Chio, Cong, Cox, Davidson, Davies, DeBerardinis, DeBerardinis, DeBerardinis, Deberardinis, DeNicola, Dixon, Fabrizio, Fellmann, Fernandez, Gaglio, Gao, Goldstein, Gorrini, Habib, Hanada, Hanahan, Hosios, Hu, Ishii, Itoh, Itoh, Jaramillo, Kim, King, Kobayashi, Konermann, Konstantinopoulos, Koppula, Lacey, Lane, Larson, Le Gal, Letouzé, Lewerenz, Lewis, Loenarz, Mayers, Mitsuishi, Muscarella, Nicklin, Nioi, Piskounova, Qie, Rhoads, Romero, Sato, Sayin, Sayin, Selak, Shibata, Shibata, Shin, Singh, Sleeman, Son, Taguchi, Tardito, Timmerman, Trachootham, Vander Heiden, Warburg, Watanabe, Waterfall, Welbourne, Wise, Wise, Xiang, Xiao, Yuneva, Yuneva   +81 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Structural arrangement of the transmission interface in the antigen ABC transport complex TAP [PDF]

, 2009
The transporter associated with antigen processing (TAP) represents a focal point in the immune recognition of virally or malignantly transformed cells by translocating proteasomal degradation products into the endoplasmic reticulum–lumen for loading of ...
Abele, Antoniou, Careaga, Chen, D. P. Tieleman, Davidson, Dawson, Dean, G. Oancea, Gorbulev, Groothuis, Guan, Hollenstein, Koch, Leonhardt, M. L. O'Mara, Meyer, Neumann, Neumann, Nijenhuis, O'mara, Peaper, Procko, R. Abele, R. Tampe, Ritz, Sali, Schmitt, Schmitt, Smith, van Endert, W. F. D. Bennett, Wu   +32 more
core   +1 more source

Coordination of Cyanobacterial Nitrate Assimilation and Photosynthesis by a Novel PsbO‐Interacting Protein PirN

Advanced Science, EarlyView.
PirN was identified as a previously uncharacterized PsbO‐interacting protein specifically induced in nitrate‐grown cyanobacteria. Loss of PirN leads to coordinated downregulation of PsbO and the nitrate reductase NarB, causing decreased PSII activity and impaired growth under nitrate conditions. Complementation with either PsbO or NarB largely restores
Chengcheng Huang, Zhen Xiao, Haitao Ge, Gaojie Wang, Jinghui Dong, Yan Wang, Hang Yang, Xing Wang, Hui Gao, Zhongshu Wang, Huanling Yang, Yuanya Zhang, Xiahe Huang, Wu Xu, Weimin Ma, Wenqiang Yang, Yingchun Wang   +16 more
wiley   +1 more source

Cell-free prediction of protein expression costs for growing cells [PDF]

, 2017
Translating heterologous proteins places significant burden on host cells, consuming expression resources leading to slower cell growth and productivity.
Borkowski, O, Bricio, C, Ellis, T, Murgiano, M, Rothschild-Mancinelli, B, Stan, G   +5 more
core   +5 more sources

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source