Results 91 to 100 of about 41,955 (229)

Consequences of PPARα Invalidation on Glutathione Synthesis: Interactions with Dietary Fatty Acids

PPAR Research, 2011
Glutathione (GSH) derives from cysteine and plays a key role in redox status. GSH synthesis is determined mainly by cysteine availability and γ-glutamate cysteine ligase (γGCL) activity.
Najoua Guelzim, Jean-François Huneau, Véronique Mathé, Annie Quignard-Boulangé, Pascal G. Martin, Daniel Tomé, Dominique Hermier   +6 more
doaj   +1 more source

Antioxidant Effects of Roasted Licorice in a Zebrafish Model and Its Mechanisms

Molecules, 2022
Licorice (Gan-Cao, licorice) is a natural antioxidant and roasted licorice is the most common processing specification used in traditional Chinese medicine prescriptions.
Qian Zhou, Shanshan Zhang, Xue Geng, Haiqiang Jiang, Yanpeng Dai, Ping Wang, Min Hua, Qi Gao, Shiyue Lang, Lijing Hou, Dianhua Shi, Meng Zhou   +11 more
doaj   +1 more source

Trim17, novel E3 ubiquitin-ligase, initiates neuronal apoptosis [PDF]

, 2010
Accumulating data indicate that the ubiquitin-proteasome system controls apoptosis by regulating the level and the function of key regulatory proteins. In this study, we identified Trim17, a member of the TRIM/RBCC protein family, as one of the critical ...
A Bobba, A Brunet, A Lipkin, A Reymond, AP Aalto, B Pettmann, CM Knudson, CM Pickart, DA Cross, DA Cross, DA Linseman, DP Martin, E Towers, F Jaudon, G Lutfalla, G Meroni, GV Putcha, I Lassot, I Robbins, J Gilley, J Ham, J Ham, J Whitfield, J Yuan, JX Comella, KA Wood, L Swainson, L Vanhille, M Broemer, M Kristiansen, M M Magiera, M Sardiello, MH Glickman, N Canu, R Bhat, R Rahmeh, R Sadoul, RJ Youle, S Desagher, S Desagher, S Mora, S Ogawa, SJ Riedl, SJ Thompson, SR D'Mello, SR Datta, T Urano, TM Miller, TM Miller, V Arce, V Hongisto, Y Du, Z Xia   +52 more
core   +5 more sources

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

The use of macroarray as a simple tool to follow the metabolic profile of Lactobacillus plantarum during fermentation [PDF]

, 2014
201
Ahola, Virpi, Joutsjoki, Vesa, Kahala, Minna, Mäkimattila, Elina, Paulin, Lars   +4 more
core   +1 more source

The relationship between polymorphisms in the glutamate cysteine ligase gene and asthma susceptibility [PDF]

Respiratory Medicine, 2007
The present study was designed to investigate an association of common -588C/T and -23G/T polymorphisms within glutamate cysteine ligase modifier subunit gene with susceptibility to bronchial asthma. A total of 435 ethnically Russian subjects were recruited in this study, including 221 patients with asthma and 214 sex and age matched healthy subjects ...
Polonikov, A.V., Ivanov, V.P., Solodilova, M.A., Khoroshaya, I.V., Kozhuhov, M.A., Panfilov, V.I.   +5 more
openaire   +2 more sources

Recombinant Monoclonal Antibodies for Detecting the Tubulin Post‐Translational Modifications Glutamylation and Lysine‐40 Acetylation

Cytoskeleton, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine‐40 (K40) on α‐tubulin (αTub‐K40ac) and glutamylation of both α‐ and β‐tubulin are two tubulin PTMs of ...
Lynne Blasius, Ezekiel C. Thomas, Erik H. Collet, Erin Jenson, Chad G. Pearson, Ryoma Ohi, Kristen J. Verhey   +6 more
wiley   +1 more source

Altered NRF2 signalling in systemic redox imbalance: Insights from non-communicable diseases

Redox Biology
The balanced activity of the cytoprotective transcription factor NRF2 is central for maintaining redox, metabolic-energetics, and proteome homeostasis, as well as for regulating inflammatory responses, among other functions.
Monika Jakubowska, Vera Marisa Costa, Wojciech Krzeptowski, Pia Pužar Dominkuš, Marlene Santos, Birsen Can Demirdöğen, Şermin Genç, Ioannis P. Trougakos, Katja M. Kanninen, Brigitte M. Winklhofer-Roob, Ian M. Copple, Antonio Cuadrado, Vita Dolžan, Christina Morgenstern   +13 more
doaj   +1 more source

Asiatic Acid Exhibits Anti-inflammatory and Antioxidant Activities against Lipopolysaccharide and d-Galactosamine-Induced Fulminant Hepatic Failure

Frontiers in Immunology, 2017
Inflammation and oxidative stress are essential for the pathogenesis of fulminant hepatic failure (FHF). Asiatic acid (AA), which is a pentacyclic triterpene that widely occurs in various vegetables and fruits, has been reported to possess antioxidant ...
Hongming Lv, Hongming Lv, Zhimin Qi, Zhimin Qi, Sisi Wang, Haihua Feng, Haihua Feng, Xuming Deng, Xuming Deng, Xinxin Ci   +9 more
doaj   +1 more source

In silico modeling and evaluation of Gordonia alkanivorans for biodesulfurization [PDF]

, 2013
10.1039/c3mb70132hMolecular BioSystems92530 ...
Aggarwal, Shilpi, Ivan, Gregorius Reinaldi, Karimi, I. A.   +2 more
core   +1 more source