Results 51 to 60 of about 41,955 (229)

Glutamate cysteine ligase up-regulation fails in necrotizing pancreatitis

Free Radical Biology and Medicine, 2008
Glutathione depletion is a key factor in the development of acute pancreatitis. Our aim was to study the regulation of glutamate cysteine ligase, the rate-limiting enzyme in glutathione synthesis, in edematous or necrotizing pancreatitis in rats. Glutathione levels were kept low in necrotizing pancreatitis for several hours, with no increase in protein
Pereda, Javier, Escobar, Javier, Sandoval, Juan, Rodriguez, Jose Luis, Sabater, Luis, Pallardo, Federico V., Torres, Luis, Franco, Luis, Vina, Jose, Lopez-Rodas, Gerardo, Sastre, Juan   +10 more
openaire   +3 more sources

Structural Basis for the Redox Control of Plant Glutamate Cysteine Ligase [PDF]

Journal of Biological Chemistry, 2006
Glutathione (GSH) plays a crucial role in plant metabolism and stress response. The rate-limiting step in the biosynthesis of GSH is catalyzed by glutamate cysteine ligase (GCL) the activity of which is tightly regulated. The regulation of plant GCLs is poorly understood.
Michael, Hothorn, Andreas, Wachter, Roland, Gromes, Tobias, Stuwe, Thomas, Rausch, Klaus, Scheffzek   +5 more
openaire   +2 more sources

Redox regulation of mitochondrial fission, protein misfolding, synaptic damage, and neuronal cell death: potential implications for Alzheimer’s and Parkinson’s diseases [PDF]

, 2010
Normal mitochondrial dynamics consist of fission and fusion events giving rise to new mitochondria, a process termed mitochondrial biogenesis.
Tomohiro Nakamura, Stuart A. Lipton, MT Lin, KJ Barnham, PJ Muchowski, J Emerit, MF Beal, SA Lipton, SA Lipton, DS Bredt, J Garthwaite, JS Beckman, SA Lipton, R Medeiros, Q Wang, C Haass, JA White, S Li, M Matos, D Trotti, WS Liang, WD Parker Jr, PH Reddy, SJ Baloyannis, X Wang, H Chen, RL Frederick, AB Knott, MJ Barsoum, E Bossy-Wetzel, C Delettre, S Zuchner, DH Cho, B Westermann, H Li, Z Li, RJ Youle, K Kijima, HR Waterham, A Nikolaev, X Wang, K Hirai, X Wang, RA Quintanilla, VS Laar Van, N Exner, JC Greene, AK Lutz, AC Poole, RK Dagda, L Nowak, ML Mayer, VL Dawson, M Lafon-Cazal, E Bonfoco, SL Budd, GE Hardingham, S Papadia, S Papadia, M Ankarcrona, GM Shankar, JW Olney, JW Olney, HS Chen, HM Abu-Soud, TJ O’Dell, DS Bredt, EM Schuman, AM Isaacs, JS Stamler, SZ Lei, ER Kandel, JS Stamler, DT Hess, G Melino, L Tenneti, S Dimmeler, JB Mannick, WK Kim, YB Choi, Z Gu, MR Hara, KK Chung, D Yao, T Uehara, SR Jaffrey, J Haendeler, I Sliskovic, JS Stamler, JS Stamler, JS Stamler, SA Lipton, G Wang, N Kang-Decker, JS Stamler, KN Houk, Z Huang, C Iadecola, P Hantraye, S Przedborski, GT Liberatore, PE Chabrier, T Kitada, H Shimura, MR Cookson, KL Lim, C Wang, ES Wong, MJ LaVoie, MM Lyles, BR Hu, KJ Conn, RV Rao, JD Atkin, S Tanaka, HS Ko, C Hetz, KK Chung, MW Cleeter, E Clementi, E Bossy-Wetzel, H Yuan, S Wasiak, DG Breckenridge, M Karbowski, N Nakamura, R Yonashiro, CR Chang, JT Cribbs, N Taguchi, HH Low, PP Zhu, R Ramachandran, KR Pitts, M Gu, AV Panov, H Wang, G Liot, E Bossy-Wetzel   +138 more
core   +2 more sources

Induction of Glutathione Synthesis Provides Cardioprotection Regulating NO, AMPK and PPARa Signaling in Ischemic Rat Hearts

Life, 2021
Glutathione (GSH) is essential for antioxidant defence, and its depletion is associated with tissue damage during cardiac ischemia-reperfusion (I/R). GSH is synthesized by the glutamate-cysteine ligase enzyme (GCL) from L-cysteine, which alternatively ...
Yulia V. Goshovska, Raisa A. Fedichkina, Volodymyr V. Balatskyi, Oksana O. Piven, Pawel Dobrzyn, Vadym F. Sagach   +5 more
doaj   +1 more source

Роль полиморфизмов генов глутаматцистеинлигазы в развитии сахарного диабета 2 типа у жителей Курской области [PDF]

, 2018
Глутаматцистеинлигаза (GCL) является первым ферментом синтеза глутатиона, внутри- и внеклеточного антиоксиданта, нарушение обмена которого играет важную роль в патогенезе сахарного диабета 2 типа (СД2).
Азарова, Ю. Э., Клесова, Е. Ю., Конопля, А. И.   +2 more
core   +2 more sources

Cardiotoxicity caused by acrylamide in rats can be alleviated as a result of suppression of oxidative stress, endoplasmic reticulum stress, inflammation, and apoptosis by morin treatment [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): The present study investigated whether morin has a protective effect against ACR-induced cardiac toxicity.Materials and Methods: In this study, oxidative stress, inflammation, endoplasmic reticulum stress (ERS), and apoptosis markers in ...
Fatma Cakmak, Sefa Kucukler, Cihan Gur, Mustafa Ileriturk, Murat Gul, Behcet Varisli   +5 more
doaj   +1 more source

The Neuroprotective Effects of Arecae Pericarpium against Glutamate-Induced HT22 Cell Cytotoxicity

Current Issues in Molecular Biology, 2022
Arecae Pericarpium has been found to exert anti-migraine, antidepressant, and antioxidative effects. However, the mechanisms involved are unclear. This study explored the possibility that Arecae Pericarpium ethanol extract (APE) exerts neuroprotective ...
Yun Hee Jeong, You-Chang Oh, Tae In Kim, Jong-Sup Bae, Jin Yeul Ma   +4 more
doaj   +1 more source

Role of G{alpha}12 and G{alpha}13 as Novel Switches for the Activity of Nrf2, a Key Antioxidative Transcription Factor [PDF]

, 2007
G{alpha}12 and G{alpha}13 function as molecular regulators responding to extracellular stimuli. NF-E2-related factor 2 (Nrf2) is involved in a protective adaptive response to oxidative stress.
Cho, Min Kyung, Choi, Sangdun, Hwang, Jong-Ik, Ki, Sung Hwan, Kim, Sang Geon, Kim, Won Dong, Lee, Chang Ho   +6 more
core   +2 more sources

Glutamate-cysteine ligase modulatory subunit in BAL alveolar macrophages of healthy smokers [PDF]

European Respiratory Journal, 2003
The antioxidant glutathione (GSH) is increased in the epithelial lining fluid (ELF) of chronic smokers. The rate-limiting enzyme in GSH synthesis is glutamate-cysteine ligase (GCL), also known as γ‐glutamylcysteine synthetase, consisting of a heavy, catalytic (GCLC) and a light, modulatory (GCLM) subunit.To determine the contribution of bronchoalveolar
C, Neurohr, A G, Lenz, I, Ding, H, Leuchte, T, Kolbe, J, Behr   +5 more
openaire   +2 more sources

The Potential Relationship Between HIF-1α and Amino Acid Metabolism After Hypoxic Ischemia and Dual Effects on Neurons

Frontiers in Neuroscience, 2021
Hypoxia inducible factor (HIF) is one of the major transcription factors through which cells and tissues adapt to hypoxic-ischemic injury. However, the specific mechanism by which HIF regulates amino acid metabolism and its effect on neurons during ...
Kexin Li, Yang Zheng, Xiaoming Wang
doaj   +1 more source