Myeloperoxidase and glutamate-cysteine ligase polymorphisms in type 2 diabetes mellitus: A preliminary study [PDF]
Journal of Medical Biochemistry, 2014 Background: Oxidative stress can accompany the physiopathology of diabetes mellitus. Myeloperoxidase and glutamate-cysteine ligase catalytic subunit are two important substances which are connected with the maintaining of the redox balance in the body ...
Eksi Yunus Emre +3 more
doaj
Dysregulation of glutathione synthesis in liver disease
Liver Research, 2020 Glutathione (GSH), a tripeptide that is present in all mammalian tissues, is especially highly concentrated in the liver. GSH synthesis occurs via two adenosine triphosphate (ATP)-requiring enzymatic steps: the first is rate-limiting, catalyzed by ...
Shelly C. Lu
doaj +1 more source
Redox Biology, 2023 Glutathione (GSH) depletion, and impaired redox homeostasis have been observed in experimental animal models and patients with epilepsy. Pleiotropic strategies that elevate GSH levels via transcriptional regulation have been shown to significantly ...
Ashwini Sri Hari +8 more
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Glutathione in Cancer Cell Death [PDF]
, 2011 Glutathione (L-γ-glutamyl-L-cysteinyl-glycine; GSH) in cancer cells is particularly relevant in the regulation of carcinogenic mechanisms; sensitivity against cytotoxic drugs, ionizing radiations, and some cytokines; DNA synthesis; and cell proliferation
Ames +184 more
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The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Cysteine improves boar sperm quality via glutathione biosynthesis during the liquid storage [PDF]
Animal Bioscience, 2022 Objective Sperm is particularly susceptible to reactive oxygen species (ROS) stress. Glutathione (GSH) is an endogenous antioxidant that regulates sperm redox homeostasis.
Zhendong Zhu, Yao Zeng, Wenxian Zeng
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Prolonged Fasting Increases Glutathione Biosynthesis in Postweaned Northern Elephant Seals [PDF]
, 2011 Published by and copyright of The Company of Biologists. The definitive version of this article is available at: http://jeb.biologists.org/content/214/8/1294.full.pdf+htmlNorthern elephant seals experience prolonged periods of absolute food and water ...
V??zquez-Medina, Jos?? Pablo +4 more
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Role of glutathione biosynthesis in endothelial dysfunction and fibrosis
Redox Biology, 2018 Glutathione (GSH) biosynthesis is essential for cellular redox homeostasis and antioxidant defense. The rate-limiting step requires glutamate-cysteine ligase (GCL), which is composed of the catalytic (GCLc) and the modulatory (GCLm) subunits. To evaluate
Cristina Espinosa-DÃez +9 more
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Zearalenone regulates key factors of the Kelch-like erythroid cell-derived protein with CNC homology-associated protein 1–nuclear factor erythroid 2-related factor 2 signaling pathway in duodenum of post-weaning gilts [PDF]
Animal Bioscience, 2021 Objective This study explored the mechanism of the Kelch-like erythroid cell-derived protein with CNC homology-associated protein 1 (Keap1)–nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway under conditions of zearalenone (ZEA)-induced
Qun Cheng +4 more
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Urinary felinine excretion in intact male cats is increased by dietary cystine [PDF]
, 2008 Felinine is a branched-chain sulfur amino acid present in the urine of certain Felidae, including domestic cats. The objective of the present study was to determine if additional cystine and/or dietary N would increase felinine and N-acetylfelinine ...
Hendriks, W.H. +4 more
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