Results 21 to 30 of about 41,955 (229)

Neuroprotective Effects and Mechanisms of Procyanidins In Vitro and In Vivo

Molecules, 2021
This study evaluated the neuroprotective effects and mechanisms of procyanidins (PCs). In vitro, rat pheochromocytoma cells (PC12 cells) were exposed to PCs (1, 2 or 4 μg/mL) or N-Acetyl-L-cysteine (NAC) (20 μM) for 24 h, and then incubated with 200 μM ...
Juan Chen, Yixuan Chen, Yangfan Zheng, Jiawen Zhao, Huilin Yu, Jiajin Zhu, Duo Li   +6 more
doaj   +1 more source

Naringenin Prevents Oxidative Stress and Inflammation in LPS-Induced Liver Injury through the Regulation of LncRNA-mRNA in Male Mice

Molecules, 2022
Inflammation accompanies hepatic dysfunction resulting from tissue oxidative damage. Naringenin (Nar), a natural flavanone, has known antioxidant and anti-inflammatory activities, but its mechanism of action in the regulation of liver dysfunction ...
Mengting Ji, Zhao Deng, Xiaoyin Rong, Ruixiao Li, Ziwei You, Xiaohong Guo, Chunbo Cai, Yan Zhao, Pengfei Gao, Guoqing Cao, Bugao Li, Yang Yang   +11 more
doaj   +1 more source

Characterization of a glutamate-cysteine ligase in Bombyx mori

Molecular Biology Reports, 2022
Abstract Background: Glutamate cysteine ligase (GCL) is a crucial enzyme involved in the synthesis of glutathione (GSH). Despite various studies on glutathione transferase and its essential role in detoxification and resistance to oxidative stress, GSH synthesis has not been described in silkworms to date.
Wazifa Afrin, Shigeki Furuya, Kohji Yamamoto   +2 more
openaire   +2 more sources

Dimethyl Fumarate Alleviates Dextran Sulfate Sodium-Induced Colitis, through the Activation of Nrf2-Mediated Antioxidant and Anti-inflammatory Pathways. [PDF]

, 2020
Oxidative stress and chronic inflammation play critical roles in the pathogenesis of ulcerative colitis (UC) and inflammatory bowel diseases (IBD). A previous study has demonstrated that dimethyl fumarate (DMF) protects mice from dextran sulfate sodium ...
Farzaneh, Ted, Ichii, Hirohito, Lau, Hien, Li, Shiri, Robles, Lourdes, Stamos, Michael J, Takasu, Chie, Vaziri, Nosratola D, Vo, Kelly   +8 more
core   +2 more sources

Probiotics prevent intestinal barrier dysfunction in acute pancreatitis in rats via induction of ileal mucosal glutathione biosynthesis. [PDF]

PLoS ONE, 2009
BACKGROUND: During acute pancreatitis (AP), oxidative stress contributes to intestinal barrier failure. We studied actions of multispecies probiotics on barrier dysfunction and oxidative stress in experimental AP.
Femke Lutgendorff, Rian M Nijmeijer, Per A Sandström, Lena M Trulsson, Karl-Eric Magnusson, Harro M Timmerman, L Paul van Minnen, Ger T Rijkers, Hein G Gooszen, Louis M A Akkermans, Johan D Söderholm   +10 more
doaj   +1 more source

Caffeic acid and protocatechuic acid modulate Nrf2 and inhibit Ehrlich ascites carcinomas in mice

Asian Pacific Journal of Tropical Biomedicine, 2021
Objective: To assess the nuclear factor-erythroid 2-related factor-2 (Nrf2) modulatory effect of caffeic acid and protocatechuic acid and determine the anti-tumor activity of these phenolic compounds against Ehrlich ascites carcinoma growth in mice ...
Venugopal R Bovilla, Preethi G Anantharaju, Sireesh Dornadula, Prashanthkumar M Veeresh, Mahadevaswamy G Kuruburu, Vidya G Bettada, Kunka Mohanram Ramkumar, SubbaRao V Madhunapantula   +7 more
doaj   +1 more source

Pre-treatment twice with liposomal clodronate protects against acetaminophen hepatotoxicity through a pre-conditioning effect

Liver Research, 2020
Background and aim: Acetaminophen (APAP) overdose is a major cause of acute liver injury, but the role of macrophages in the propagation of the hepatotoxicity is controversial.
Melissa M. Clemens, Joel H. Vazquez, Stefanie Kennon-McGill, Sandra S. McCullough, Laura P. James, Mitchell R. McGill   +5 more
doaj   +1 more source

Deletion of P2X7 Receptor Decreases Basal Glutathione Level by Changing Glutamate-Glutamine Cycle and Neutral Amino Acid Transporters

Cells, 2020
Glutathione (GSH) is an endogenous tripeptide antioxidant that consists of glutamate-cysteine-glycine. GSH content is limited by the availability of glutamate and cysteine.
Hana Park, Ji-Eun Kim
doaj   +1 more source

Mechanisms of Yajieshaba in the treatment of liver fibrosis through the Keap1-Nrf2 signaling pathway

Frontiers in Pharmacology, 2023
Yajieshaba (YJSB), a traditional Dai medicine formula containing botanical drugs, is commonly employed in Yunnan due to its significant therapeutic effects on liver protection.
Yuanmei Bai, Haimei Wu, Lijie Zheng, Yuhuan Xie, Feifan Liu, Yan Wan, Qiongchao Li, Peixin Guo   +7 more
doaj   +1 more source

Asarone from Acori Tatarinowii Rhizome prevents oxidative stress-induced cell injury in cultured astrocytes: A signaling triggered by Akt activation. [PDF]

PLoS ONE, 2017
Acori Tatarinowii Rhizome (ATR; the dried rhizome of Acori tatarinowii Schott) is a well-known herb being used for mental disorder in China and Asia. Volatile oil is considered as the active ingredient of ATR, and asarones account for more than 90% of ...
Kelly Y C Lam, Ping Yao, Huaiyou Wang, Ran Duan, Tina T X Dong, Karl W K Tsim   +5 more
doaj   +1 more source