Results 61 to 70 of about 41,955 (229)

Specificity determinants for lysine incorporation in staphylococcus aureus peptidoglycan as revealed by the structure of a MurE enzyme ternary complex [PDF]

, 2013
Background: MurE controls stereo chemical incorporation of Lysine or diaminopimelate into peptidoglycan stem peptides Results: The structure of S.aureus MurE reveals an unexpected lack of specificity for Lysine within the active site.
Barreteau, Basavannacharya, Basavannacharya, Battye, Bertrand, Bertrand, Boniface, Boniface, Bouhss, Brünger, Bugg, Bugg, Chen, Clancy, Clarke, Clarke, Collaborative Computational Project, Number 4, Cox, Cressina, Crouvoisier, Cruickshank, De Lencastre, DeLano, Emsley, Ernst, Ernst, Favini-Stabile, Figueiredo, Gardete, Girardin, Gordon, Gorrec, Huber, Hutton, Jones, Kabsch, Lee, Liebeke, Lloyd, Lloyd, Lundqvist, Lysenko, Matteï, McCoy, Mei, Mengin-Lecreulx, Mengin-Lecreulx, Mohammadi, Murshudov, Münch, Ornelas-Soares, Painter, Paradis-Bleau, Paradis-Bleau, Patin, Perdih, Ray, Read, Royet, Sauvage, Scheffers, Schneider, Schouten, Smith, Sosič, Sova, Thedieck, Vagin, Vollmer, Vollmer, Walker, Young, Zawadzke   +72 more
core   +2 more sources

Schizophrenia and Oxidative Stress: Glutamate Cysteine Ligase Modifier as a Susceptibility Gene [PDF]

The American Journal of Human Genetics, 2006
Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is decreased in patients' cerebrospinal fluid and prefrontal cortex. The gene of the key GSH-synthesizing enzyme, glutamate cysteine ligase modifier (GCLM) subunit, is strongly associated with schizophrenia in ...
Tosic, Mirjana, Ott, Jurg, Barral, Sandra, Bovet, Pierre, Deppen, Patricia, Gheorghita, Fulvia, Matthey, Marie-Louise, Parnas, Josef, Preisig, Martin, Saraga, Michael, Solida, Alessandra, Timm, Sally, Wang, August G, Werge, Thomas, Cuénod, Michel, Do, Kim Quang   +15 more
openaire   +3 more sources

Genetic variants of microsomal epoxide hydrolase and glutamate-cysteine ligase in COPD [PDF]

European Respiratory Journal, 2008
The genetic factors that contribute to the development of chronic obstructive pulmonary disease (COPD) are poorly understood. Many candidate genes have been proposed, including enzymes that protect the lung against oxidative stress, such as microsomal epoxide hydrolase (EPHX1) and glutamate-cysteine ligase (GCL).
Chappell S, Daly L, Morgan K, GuettaBaranes T, Roca J, Rabinovich R, Lotya J, Millar A, Donnelly SC, Keatings V, McNee W, Stolk J, Hiemstra P, Miniati M, Monti S, OConnor CM, Kalsheker N   +16 more
openaire   +3 more sources

Nrf2–ARE Signaling Acts as Master Pathway for the Cellular Antioxidant Activity of Fisetin

Molecules, 2019
Fisetin, a dietary flavonoid, is reported to have cellular antioxidant activity with an unclear mechanism. In this study, we investigated the effect of fisetin on the nuclear factor, erythroid 2-like 2 (Nrf2) signaling pathway in HepG2 cells to explore ...
Huihui Zhang, Wan Zheng, Xiangling Feng, Fei Yang, Hong Qin, Shusong Wu, De-Xing Hou, Jihua Chen   +7 more
doaj   +1 more source

Polymorphisms in the glutathione pathway modulate cystic fibrosis severity: a cross-sectional study [PDF]

, 2014
BACKGROUND: Cystic fibrosis (CF) clinically manifests with various levels of severity, which are thought to be modulated by mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR), modifier genes, and the environment.
Antonio Fernando Ribeiro, Carmen Silvia Bertuzzo, Fernando Augusto de Fernando August Marson, Jose Dirceu Ribeiro   +3 more
core   +1 more source

RBR E3 ubiquitin ligases: new structures, new insights, new questions [PDF]

, 2014
The RBR (RING-BetweenRING-RING) or TRIAD [two RING fingers and a DRIL (double RING finger linked)] E3 ubiquitin ligases comprise a group of 12 complex multidomain enzymes.
Shaw, Gary S., Spratt, Donald E., Walden, Helen   +2 more
core   +1 more source

Non-canonical glutamate-cysteine ligase activity protects against ferroptosis

, 2020
AbstractCysteine is required for maintaining cellular redox homeostasis in both normal and transformed cells. Deprivation of cysteine induces the iron-dependent form of cell death known as ferroptosis; however, the metabolic consequences of cysteine starvation beyond impairment of glutathione synthesis are uncharacterized.
Yun Pyo Kang, Andrea Mockabee-Macias, Chang Jiang, Isaac S. Harris, Gina M. DeNicola   +4 more
openaire   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Pharmacology and clinical drug candidates in redox medicine [PDF]

, 2015
SIGNIFICANCE Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation of this, for example, based on chemical scavenging of pro-oxidant ...
Casas, Ana I, Cuadrado, Antonio, Dao, V Thao-Vi, Di Lisa, Fabio, Ghezzi, Pietro, Jaquet, Vincent, Kaludercic, Nina, Maghzal, Ghassan J, Robledinos-Anton, Natalia, Schmidt, Harald H H W, Seredenina, Tamara, Stocker, Roland   +11 more
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source