Results 121 to 130 of about 41,570 (221)

C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape [PDF]

, 2018
Numerous small molecules (termed inducers), many of which are electrophiles, upregulate cytoprotective responses and inhibit pro-inflammatory pathways by activating nuclear factor-erythroid 2 p45-related factor 2 (NRF2).
A Cleasby, A Cuadrado, A Kobayashi, AI Rojo, AL Levonen, AT Dinkova-Kostova, AT Dinkova-Kostova, AT Dinkova-Kostova, AT Dinkova-Kostova, AT Dinkova-Kostova, C Huerta, D Olagnier, DD Zhang, DD Zhang, E Chan, EH Kobayashi, EL Mills, EV Knatko, EV Knatko, FG Favaloro Jr, H Liu, HJ Prochaska, I Almazari, I Pitha-Rowe, J Alam, JD Hayes, K Itoh, K Itoh, K Liby, K Takaya, M Hayashi, M McMahon, MM Yore, N Suh, N Wakabayashi, P Rada, P Rada, P Talalay, R Saito, RK Thimmulappa, RS Sharma, RV Bensasson, RV Kostov, S Chowdhry, S Chowdhry, S Zheng, SB Cullinan, T Honda, T Honda, T Honda, T Honda, T Honda, T Prestera, T Shekh-Ahmad, T Suzuki, T Yamamoto, TW Kensler, V Duplan, V Sihvola, W Li, W Li, W Yao   +61 more
core   +3 more sources

Coenzyme A mitigates cystine‐deprivation‐induced ferroptosis by suppressing the iron‐starvation response

The FEBS Journal, EarlyView.
Cystine (Cys2) deprivation in pancreatic cancer cells induces oxidative stress that destabilizes cytosolic iron–sulfur cluster (ISC) proteins, triggering an iron‐regulatory protein (IRP)‐mediated iron‐starvation response (ISR). This leads to increased iron uptake (via TFRC), an expanded labile iron pool, and ferroptosis.
Mingjun Tan, Yunzhan Li, Lei Sang, Min Wang, Qin Li, Zekun Li, Dongxiao Sun, Xiuchao Wang, Shengyu Yang   +8 more
wiley   +1 more source

Glutamate Cysteine Ligase Catalysis [PDF]

Journal of Biological Chemistry, 2005
Ying Chen, Howard G. Shertzer, Scott N. Schneider, Daniel W. Nebert, Timothy P. Dalton   +4 more
openaire   +1 more source

Metabolic Changes Following Perinatal Asphyxia: Role of Astrocytes and Their Interaction with Neurons [PDF]

, 2016
Perinatal Asphyxia (PA) represents an important cause of severe neurological deficits including delayed mental and motor development, epilepsy, major cognitive deficits and blindness.
Barreto, George E., Capani, Francisco, Castilla Lozano, Maria del Rocio, Holubiec, Mariana Ines, Logica Tornatore, Tamara Maite Ayelén, Riviere, Stephanie   +5 more
core   +1 more source

An atlas of plant selenium metabolism

New Phytologist, EarlyView.
Summary Selenium (Se) is not only a rare and toxic element but also an essential micronutrient for humans and animals that is often in short supply. Terrestrial plants do not require Se, but it can have growth‐promoting or negative effects, depending on the exposure level.
Jeroen van der Woude, Mark G. M. Aarts, Michela Schiavon, Antony van der Ent   +3 more
wiley   +1 more source

Loss of UCHL1 promotes age-related degenerative changes in the enteric nervous system [PDF]

, 2014
UCHL1 (ubiquitin carboxyterminal hydrolase 1) is a deubiquitinating enzyme that is particularly abundant in neurons. From studies of a spontaneous mutation arising in a mouse line it is clear that loss of function of UCHL1 generates profound degenerative
Douglas A. Gray, John Woulfe, Josée Coulombe, M. Jill Saffrey, Madison T. Gray, Matthew Y. Tang, Mei Zhang, Prasanna Gamage   +7 more
core   +1 more source

Enhanced Expression of Glutathione S-Transferase in the Hippocampus Following Acute Treatment With Trimethyltin In Vivo

Journal of Pharmacological Sciences, 2010
We investigated the effects of treatment with trimethyltin (TMT) on the expression of glutathione-related enzymes in mouse hippocampus. TMT promoted the expression of glutathione S-transferase (GST) Ya/Yc mRNA, and GSTA2 protein, but not that of ...
Reiko Nagashima, Shohei Sano, Nguyen Quynh Huong, Tatsuo Shiba, Kiyokazu Ogita   +4 more
doaj   +1 more source

Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H:quinone oxidoreductase 1 in Hepa1c1c7 cells [PDF]

, 2017
Silybum marianum (milk thistle) is a medicinal plant used for the treatment of various liver disorders. This study examined whether the main flavonolignans from S. marianum (i.e.
Abenavoli, Albena T. Dinkova-Kostova, Baird, Begum, Biedermann, Biedermann, Bonifaz, Borsari, Chambers, Chow, David Biedermann, Dinkova-Kostova, Dvorak, Dzubak, Fahey, Federico, Feher, Gazak, Gazak, Hayes, Jitka Ulrichová, Jiří Vrba, Krenek, Lenka Roubalová, Liang, Nioi, Prochazkova, Pyszkova, Roubalova, Surai, Tanigawa, Thongphasuk, Trouillas, Varga, Vladimír Křen, Vrba, Wang, Zhan, Zhang, Zhao   +39 more
core   +2 more sources

Lactate potentiates NMDA receptor currents via an intracellular redox mechanism targeting GluN2B subunits: implications for synaptic plasticity

The Journal of Physiology, EarlyView.
Abstract figure legend Astrocyte‐derived lactate enhances neuronal NMDA receptor (NMDAR) function and synaptic plasticity through a redox‐ and CaMKII‐dependent mechanism. Lactate enters neurons via monocarboxylate transporters (MCTs) and is oxidized by lactate dehydrogenase (LDH) to pyruvate, generating NADH and increasing the intracellular NADH/NAD ...
Hubert Fiumelli, Gabriel Herrera‐López, Fouad Lemtiri‐Chlieh, Lorène Mottier, John Girgis, Carine Ben‐Adiba, Pascal Jourdain, Nicolò Carrano, Hanan Mahmood, Amanda Ooi, Stefan T. Arold, Monica Di Luca, Fabrizio Gardoni, Pierre J. Magistretti   +13 more
wiley   +1 more source

Astaxanthin attenuates AFB1-induced hepatotoxicity by activating Nrf2 and inhibiting the NF-κB signaling pathway

Ecotoxicology and Environmental Safety
Aflatoxin B1 (AFB1)-induced hepatotoxicity is a common toxic disease in poultry farming. However, there is currently a lack of effective pharmaceutical interventions for treating AFB1.
Kai Kang, Yueying Zhang, Weitian Xie, Wenao Ma, Jinjun Chen, Zhibao Chen   +5 more
doaj   +1 more source