Results 111 to 120 of about 716,780 (343)

Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain [PDF]

, 2017
Background: L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors in the spinal cord.
Battaglia, Giuseppe, Bernabucci, Matteo, Bruno, Valeria Maria Gloria, Cannella, Milena, Gradini, Roberto, Imbriglio, Tiziana, Mascio, Giada, Nicoletti, Ferdinando, Notartomaso, Serena, Scarselli, Pamela, Zappulla, Cristina   +10 more
core   +1 more source

Rapid Deep Vat Printing Using Photoclickable Collagen‐Based Bioresins

Advanced Healthcare Materials, EarlyView.
Collagen‐based resin formulations based on thiol‐ene photoclick chemistry are demonstrated. These resins enable easy handleability under neutral conditions and further allow facile fabrication of multicellular tissue constructs via tomographic or FLight printing.
Michael Winkelbauer, Amelia Hasenauer, Dominic Rütsche, Hao Liu, Jakub Janiak, Michael Nguyen, Karen L. Christman, Marcy Zenobi‐Wong, Parth Chansoria   +8 more
wiley   +1 more source

Localization of NMDA receptors in the cerebral cortex: a schematic overview

Brazilian Journal of Medical and Biological Research, 1997
The fundamental role of N-methyl-D-aspartate (NMDA) receptors in many cortical functions has been firmly defined, as has its involvement in a number of neurological and psychiatric diseases.
F. Conti
doaj   +1 more source

Loss of FKBP5 Affects Neuron Synaptic Plasticity: An Electrophysiology Insight [PDF]

, 2019
FKBP5 (FKBP51) is a glucocorticoid receptor (GR) binding protein, which acts as a co-chaperone of heat shock protein 90 (HSP90) and negatively regulates GR.
Deng, Ran, Dou, Longyu, Liang, Tiebing, Liu, Ming, Qiu, Bin, Ren, Wei, Shou, Weinian, Stewart, Robert B., Wang, Chao, Wang, Jun, Williams, Kent E., Xie, Zhongwen, Xu, Yuxue, Yong, Weidong, Zhao, Zhenwen   +14 more
core   +1 more source

Immunomodulation With Local, Sustained Delivery of Pituitary Adenylate Cyclase Activating Polypeptide Results in Improved Functional Recovery in Stroke‐Injured Mice

Advanced Healthcare Materials, EarlyView.
The tissue and functional benefits are demonstrated with local, sustained delivery of an anti‐inflammatory peptide, pituitary adenylate cyclase‐activating polypeptide (PACAP), for stroke treatment in a mouse model. Prolonged PACAP treatment modulated astrocyte and microglia toward pro‐reparative phenotypes, enhanced neuroprotection and preservation of ...
Eric Ho, David Xinzheyang Li, Hong Cui, Dania Akbar, Ricky Siu, Cindi M. Morshead, David Chatenet, Molly S. Shoichet   +7 more
wiley   +1 more source

Glutamate Receptor Channel Kinetics

Biophysical Journal, 1988
Single channel recordings from the locust muscle D-glutamate receptor channel were obtained using glutamate concentrations ranging from 10(-6) to 10(-2) M. Channel kinetics were analyzed to aid in the development of a model for the gating mechanism.
R. L. Ramsey, Mark S.P. Sansom, Peter N.R. Usherwood, C. J. Kerry   +3 more
openaire   +3 more sources

Blunted Cystine–Glutamate Antiporter Function in the Nucleus Accumbens Promotes Cocaine-induced Drug Seeking [PDF]

, 2008
Repeated cocaine alters glutamate neurotransmission, in part, by reducing cystine–glutamate exchange via system xc−, which maintains glutamate levels and receptor stimulation in the extrasynaptic compartment.
Abdulhameed, Omer, Baker, David A., Grier, Mark D., Kau, Kristen S., Madayag, Aric, Mantsch, John R.   +5 more
core   +1 more source

Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule [PDF]

, 2015
N-methyl-D-aspartate receptors (NMDARs) mediate synaptic plasticity, and their dysfunction is implicated in multiple brain disorders. NMDARs can be allosterically modulated by numerous compounds, including endogenous neurosteroid pregnanolone sulfate ...
A Malayev, A Sali, A Villarroel, AI Sobolevskii, AI Sobolevsky, AI Sobolevsky, AI Sobolevsky, BO Dubrovsky, C Beck, CE Weaver, CE Weaver Jr., CH Lee, CL Kussius, CT Smothers, CT Smothers, E Karakas, E Stastna, EE Baulieu, G Abdrachmanova, GQ Chen, H Havlikova, HR Chang, I Cerny, J Borovska, J Dai, J Zuo, JA Kemp, K Kashiwagi, K Vales, L Nowak, L Rambousek, L Vyklicky Jr., LM Arnostova, LP Wollmuth, M Benveniste, M Hollmann, M Horak, M Korinek, M Park-Chung, M Park-Chung, M Park-Chung, M Petrovic, M Sheng, M Xu, MA Larkin, MA Lomize, MA Lynch, MF Sanner, ML Mayer, MM Zarei, N Kashiwabuchi, NJ Sucher, PA Lapchak, R Kancheva, R Kazi, R Sprengel, RH Evans, S Schreier, SE Murthy, SF Traynelis, SH Mellon, SI Mota   +61 more
core   +1 more source

Rolling Ultrasharp Microneedle Spheres Enable Topical Delivery of Biologics Through the Skin

Advanced Healthcare Materials, EarlyView.
Rolling ultraminiaturized microneedle spheres (RUMS), created via two‐photon polymerization, unlock effective and painless topical delivery of messenger RNA (mRNA) and drugs through the skin. By gently forming thousands of microscopic pores, RUMS boost skin permeability by up to 100‐fold.
Theocharis Nikiforos Iordanidis, Argyris Spyrou, Samantha Roudi, Fredrik J. Swartling, Göran Stemme, Samir EL Andaloussi, Niclas Roxhed   +6 more
wiley   +1 more source

Determining the neurotransmitter concentration profile at active synapses [PDF]

, 2009
Establishing the temporal and concentration profiles of neurotransmitters during synaptic release is an essential step towards understanding the basic properties of inter-neuronal communication in the central nervous system.
A Barberis, A Scimemi, A Tao, A Triller, AE Spruce, AG Ogston, AI Gulyas, AM Aravanis, Annalisa Scimemi, AV Hill, B Barbour, B Ceccarelli, B Granseth, B Katz, C Auger, C Nicholson, C Nicholson, C Nicholson, C Racca, D Colquhoun, D Colquhoun, D Sulzer, DA Rusakov, DE Bergles, DM Kullmann, DR Copenhagen, E Betzig, E Neher, E Sykova, EL Botvinick, EN Pothos, EP Huang, F Asztely, F Pouille, G Brasnjo, G Liu, G Szapiro, G Tong, GH Acheson, GH Patterson, H Korn, H Korn, H Shroff, HC Hartzell, IM Raman, J Balaji, J Castillo Del, J Hrabe, J Matthews-Bellinger, J Szabadics, JC Eccles, JC Eccles, JC Eccles, JD Clements, JE Heuser, JH Singer, JI Wadiche, JI Wadiche, JJ Celentano, JM Bekkers, JM Christie, JM Fernandez, JR Stiles, JS Diamond, JS Diamond, JS Diamond, JW Mozrzymas, JW Mozrzymas, K Belaya, K Krnjevic, K Luby-Phelps, K Zheng, KA Foster, KE Sorra, KL Magleby, KM Franks, KP Lehre, L He, L Tao, LG Longsworth, LM Levy, LM Wahl, LP Savtchenko, LS Overstreet, M Beato, M Beato, M Beato, MA Medina, Marco Beato, MI Banks, MJ Higley, MV Jones, MY Min, N Arnth-Jensen, N Harata, N Riveros, NC Harata, O Prange, P Fatt, P Fatt, P Legendre, PJ Kruk, PM Burger, Q Zhang, Q Zhang, R Ando, R Conti, R Renden, R Ventura, RG Thorne, RH Chow, RM Wightman, RW Daniels, RY Tsien, S Habuchi, S Hrabetova, S Manley, S Namiki, S Okumoto, S Takamori, SA Hires, SJ Pitt, SP Gandhi, SW Kuffler, SY Breusegem, T Lu, T Schikorski, T Schikorski, TA Nielsen, TG Allen, TG Banke, TG Oertner, TM Bartol Jr, V Burzomato, VA Levin, W Almers, W Lu, X Chen, XS Wu, Y Dehnes, Y Takumi, YH Huang, Z Nusser, Z Petrasek, Z Petrasek   +144 more
core   +2 more sources