Results 271 to 280 of about 898,814 (388)

Modulatory effects of GLT-1 enhancer, MC-100093, on glutamate uptake and associated signaling pathways in female and male alcohol preferring rats exposed to ethanol. [PDF]

Int J Neuropsychopharmacol
Alotaibi A, Bhowmik KK, Wong W, Mohammed AS, Abou-Gharbia M, Childers W, Sari Y.   +6 more
europepmc   +1 more source

The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission

Nature Reviews Neuroscience, 2011
M. Popoli, Zhen Yan, B. McEwen, G. Sanacora   +3 more
semanticscholar   +1 more source

A Dynamic Gate Enables Regioselective Hydroxylation of Free Arginine by a Non‐Canonical Heme Enzyme

Advanced Science, EarlyView.
The YqcI/YcgG enzyme AglA employs a unique “sandwich” fold and a dynamic gating mechanism to selectively hydroxylate AMPn‐Arg at Nε. Site‐directed mutations reprogram regioselectivity or enable activity on free arginine by altering hydrogen‐bond networks, precisely positioning substrates.
Yuan Sun, Chao Dou, Weizhu Yan, Pengpeng Chen, Lu Zhang, Dan Zhou, Yanhui Zheng, Zhaolin Long, Shoujie Li, Xiaoqing Xu, Qiuxia Huang, Xiaofeng Zhu, Wei Cheng   +12 more
wiley   +1 more source

Ceftriaxone alleviates mitochondrial damage through the inhibition of extrasynaptic NMDA receptor-mediated changes in intracellular calcium levels to improve cognitive deficits in APP/PS1 mice. [PDF]

Alzheimers Res Ther
Liu LR, Li L, Lu LL, Fan SJ, Liu LZ, He RB, Li H, Xian XH, Li WB.   +8 more
europepmc   +1 more source

Glutamate and Its Receptors as Therapeutic Targets for Migraine

Neurotherapeutics, 2018
J. Hoffmann, A. Charles
semanticscholar   +1 more source

An Efficient CO2‐Upcycling Platform Based on Engineered Halomonas TD with Enhanced Acetate‐Utilizing Capacity via Adaptive Laboratory Evolution

Advanced Science, EarlyView.
An electrochemical system is designed to convert CO2 into CO2‐derived electrolytes (CDE), mainly containing acetate and formate. The underlying mechanism of acetate metabolism in Halomonas TD80 is explored via ALE. Engineered TD80 produced high‐yield diversified products from CDE.
Chi Wang, Ting‐Ting Chen, Yu‐Jiao Yang, Yu‐Xi Li, Yi‐Xin Chang, Yan‐Chun Xiao, Wen‐Tai Guo, Ye Zheng, Rui‐Zhe Deng, Yu‐Xiang Tian, Wei Situ, Hong‐Wei Shen, Yu Chen, Ya‐Bin Wang, Jie Xing, Hui Wang, Lin Xia, Yi‐Na Lin, Jian‐Wen Ye   +18 more
wiley   +1 more source

Oxymatrine Alleviates Cerebral Ischemia/Reperfusion Injury By Targeting HDAC1 to Regulate Mitochondria-Related Autophagy and Oxidative Stress. [PDF]

Mol Neurobiol
Ma CS, Han B, Liu YX, Shi CK, Li DL, Guo JF, Bai M, Meng SC, Zhang LY, Duan MY, He MT.   +10 more
europepmc   +1 more source

Regulation of astrocyte glutamate transporter-1 (GLT1) and aquaporin-4 (AQP4) expression in a model of epilepsy

, 2016
Jacqueline A. Hubbard, Jenny I. Szu, Jennifer M. Yonan, Devin K. Binder   +3 more
openalex   +1 more source

GLUL Confers Perivascular Cancer‐Associated Fibroblasts With Pro‐Angiogenic Capacity to Promote Glioma Progression

Advanced Science, EarlyView.
Schematic illustration of the proposed model. Primary CAFs are isolated from fresh human GBM specimens according to established protocols. GLUL is essential for pro‐angiogenic capacity of CAFs through its impact on the PI3K/AKT pathway. GLUL enhances the pro‐angiogenic capacity of CAFs, driving aberrant tumor vasculature that fuels tumor growth ...
Qing Zhang, Yida Liu, Zhi Zhang, Yang Wang, Fusheng Liu   +4 more
wiley   +1 more source

Exogenous glutamate potentiates gentamicin to kill multidrug- and carbapenem-resistant <i>Pseudomonas aeruginosa</i> by activating the biosynthesis of unsaturated fatty acids. [PDF]

mSystems
Lai H-F, Pan L, Song K-Y, Dai Z-Y, Liang Y, Yuan W, Chen Z-G, Yang L-F.   +7 more
europepmc   +1 more source