Targeting Histamine H4 Receptor in the Rostral Ventromedial Medulla to Relieve Hypertension
Advanced Science, Volume 12, Issue 45, December 4, 2025.H4R and its downstream TRPV1 channel mediate the excitatory effect of TMN histaminergic afferent inputs on GABAergic sympathoinhibitory neurons in RVMM. Intranasal delivery of selective H4R agonist VUF 8430 suppresses renal sympathetic outflow and elicits sustained depressor and bradycardia responses in SHRs and CUMS‐induced hypertensive rats ...
Ying Shi +18 more
wiley +1 more source
Demyelination-induced glutamatergic imbalance mediates hippocampal Hyperexcitability
Neurobiology of DiseaseChronic demyelination is a hallmark of multiple sclerosis (MS) and is associated with increased seizure susceptibility. In this study, we used the cuprizone (CPZ) diet induced demyelination model to investigate the progression of hippocampal ...
Alyssa M. Anderson +9 more
doaj +1 more source
miR-4284 Functions as a Tumor Suppressor in Renal Cell Carcinoma Cells by Targeting Glutamate Decarboxylase 1. [PDF]
Cancers (Basel), 2023 Choi S +7 more
europepmc +1 more source
Integrating Astrocytes in the Sleep–Wake Cycle: The Time Is Now
BioEssays, Volume 47, Issue 12, December 2025.Astrocytes actively regulate sleep homeostatic and circadian rheostatic processes, underpinning the sleep–wake cycle. By acting as context‐dependent integrators of internal state and rhythmic environmental inputs, they modulate the encoding properties of neuronal circuitries and contribute to salient temporal representations in the brain.
Marco Brancaccio
wiley +1 more source
γ-Aminobutyric acid is involved in overlapping pathways against chilling injury by modulating glutamate decarboxylase and defense responses in papaya fruit. [PDF]
Front Plant Sci, 2023 Khaliq G +7 more
europepmc +1 more source
The Aging Gut–Brain Axis: Effects of Dietary Polyphenols and Metal Exposure
Chronic Diseases and Translational Medicine, Volume 11, Issue 4, Page 251-268, December 2025.The influence of gut microbiota on brain health ABSTRACT Diet provides essential metals, which are required for the growth, development, and well‐functioning of the body. Nonetheless, some natural and human activities add toxic heavy metals to the diet, consequently introducing them to our bodies, resulting in several disorders and death. The intestine,
Luqi Cao +7 more
wiley +1 more source
MicrobiologyOpen, Volume 14, Issue 6, December 2025.This study explores the genomic and metabolic characterization of a potentially novel Paenibacillus species isolated from cotton plant tissues. Phylogenetic analysis based on multi‐locus sequence data from six conserved genes reveals that Paenibacillus sp. TAB_01 forms a distinct lineage among 19 Paenibacillus species. Paenibacillus sp.
Ilksen Topcu +5 more
wiley +1 more source
MicrobiologyOpen, Volume 14, Issue 6, December 2025.Visualization of significantly enriched KEGG pathways under different stress conditions: (A) stationary phase cells exposed to 15 mM hydrogen peroxide, (B) stationary phase cells exposed to 1% lactic acid, (C) logarithmic phase cells exposed to 15 mM hydrogen peroxide, and (D) logarithmic phase cells exposed to 1% lactic acid.
Jessica L. Strathman‐Runyan +2 more
wiley +1 more source
The metabolic reprogramming of γ-aminobutyrate in oral squamous cell carcinoma
BMC Oral HealthOral squamous cell carcinoma (OSCC) is the most common head and neck malignancy. The oncometabolites have been studied in OSCC, but the mechanism of metabolic reprogramming remains unclear.
Shi-Lian Wu +4 more
doaj +1 more source
Visualization of Glutamate Decarboxylase Activity in Barley Seeds under Salinity Stress Using Mass Microscope. [PDF]
Metabolites, 2022 Ikuta S, Fukusaki E, Shimma S.
europepmc +1 more source