Expanding the pH range of glutamate decarboxylase from L. pltarum LC84 by site-directed mutagenesis [PDF]
Frontiers in Bioengineering and Biotechnology, 2023 Introduction: Glutamate decarboxylase is a class Ⅱ amino acid decarboxylase dependent onpyridoxal-5′-phosphate (PLP), which catalyzes the decarboxylation of substrateL-glutamate (L-Glu) to synthesize γ-aminobutyric acid (GABA).
Lijuan Yang +6 more
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Parallel Strategy Increases the Thermostability and Activity of Glutamate Decarboxylase [PDF]
Molecules, 2020 Glutamate decarboxylase (GAD; EC 4.1.1.15) is a unique pyridoxal 5-phosphate (PLP)-dependent enzyme that specifically catalyzes the decarboxylation of L-glutamic acid to produce γ-aminobutyric acid (GABA), which exhibits several well-known ...
Qing-Fei Zhang +5 more
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The Glutaminase-Dependent System Confers Extreme Acid Resistance to New Species and Atypical Strains of Brucella [PDF]
Frontiers in Microbiology, 2017 Neutralophilic bacteria have developed specific mechanisms to cope with the acid stress encountered in environments such as soil, fermented foods, and host compartments. In Escherichia coli, the glutamate decarboxylase (Gad)-dependent system is extremely
Luca Freddi +7 more
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Divergent evolution of the activity and regulation of the glutamate decarboxylase systems in Listeria monocytogenes EGD-e and 10403S: roles in virulence and acid tolerance. [PDF]
PLoS ONE, 2014 The glutamate decarboxylase (GAD) system has been shown to be important for the survival of Listeria monocytogenes in low pH environments. The bacterium can use this faculty to maintain pH homeostasis under acidic conditions.
Conor Feehily +6 more
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Global knockdown of glutamate decarboxylase 67 elicits emotional abnormality in mice [PDF]
Molecular Brain, 2021 Reduced expression of glutamate decarboxylase 67 (GAD67), encoded by the Gad1 gene, is a consistent finding in postmortem brains of patients with several psychiatric disorders, including schizophrenia, bipolar disorder and major depressive disorder.
Shigeo Miyata +12 more
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Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. [PDF]
Journal of Experimental Medicine, 1996 We previously demonstrated that a spontaneous Th1 response against glutamate decarboxylase (GAD65) arises in NOD mice at four weeks in age and subsequently T cell autoimmunity spreads both intramolecularly and intermolecularly.
Atkinson, MA +6 more
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A plasmid-borne gadRCB operon contributes to acid tolerance in Lactiplantibacillus plantarum ZR79 [PDF]
Applied Microbiology and BiotechnologyThe glutamate decarboxylase (GAD) system catalyzed the conversion of L-glutamate to gamma-aminobutyric acid (GABA) in a proton-consuming reaction, which played a critical role to maintain intracellular pH homeostasis.
Chengfei Fan +5 more
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Oxygen, 2023 Flooding induces low-oxygen stress, which reduces plant growth. The activity of the γ-aminobutyric acid (GABA) shunt is crucial for plant stress adaptation, in which it acts by changing cytosolic pH, limiting reactive oxygen species production ...
Setsuko Komatsu +2 more
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Glutamic Acid Decarboxylase in Legumes [PDF]
Nature, 1956 Since the pioneer researches of Okuniki1,2 and Schales and his associates3–5 on glutamic acid decarboxylase, rather scanty data have been made available on amino-acid decarboxylases of plants. Most of the work deals with glutamic acid decarboxylase of higher plants; so it was thought of interest to study the enzyme system in the case of dry seeds of ...
L, KULKARNI, K, SOHONIE
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SdiA Improves the Acid Tolerance of E. coli by Regulating GadW and GadY Expression
Frontiers in Microbiology, 2020 The acid tolerance mechanism is important for Escherichia coli to resist acidic conditions encountered in mammalian host digestive tract environment. Here, we explored how the LuxR protein SdiA influenced E.
Xingyan Ma +16 more
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