Results 21 to 30 of about 30,715 (166)

Paradoxical network excitation by glutamate release from VGluT3+ GABAergic interneurons

eLife, 2020
In violation of Dale’s principle several neuronal subtypes utilize more than one classical neurotransmitter. Molecular identification of vesicular glutamate transporter three and cholecystokinin expressing cortical interneurons (CCK+VGluT3+INTs) has ...
Kenneth A Pelkey, Daniela Calvigioni, Calvin Fang, Geoffrey Vargish, Tyler Ekins, Kurt Auville, Jason C Wester, Mandy Lai, Connie Mackenzie-Gray Scott, Xiaoqing Yuan, Steven Hunt, Daniel Abebe, Qing Xu, Jordane Dimidschstein, Gordon Fishell, Ramesh Chittajallu, Chris J McBain   +16 more
doaj   +1 more source

An H-NS Family Protein, Sfh, Regulates Acid Resistance by Inhibition of Glutamate Decarboxylase Expression in Shigella flexneri 2457T

Frontiers in Microbiology, 2017
The glutamate-dependent acid-resistance system is the most effective acid tolerance pathway in Shigella, allowing survival in extremely acidic environments. However, the regulation of this system in Shigella remains elusive.
Chang Niu, Chang Niu, Dongshu Wang, Xiaoqing Liu, Hongsheng Liu, Xiankai Liu, Erling Feng, Chao Pan, Ruifeng Wang, Wei Xiao, Xingming Liu, Xinrui Liu, Li Zhu, Hengliang Wang   +13 more
doaj   +1 more source

A randomized trial of oral gamma aminobutyric acid (GABA) or the combination of GABA with glutamic acid decarboxylase (GAD) on pancreatic islet endocrine function in children with newly diagnosed type 1 diabetes

Nature Communications, 2022
Based on preclinical studies, gamma aminobutyric acid (GABA) and immunization for the enzyme that produces GABA glutamate decarboxylase (GAD) could be a potential therapy for type 1 diabetes.
Alexandra Martin, Gail J. Mick, Heather M. Choat, Alison A. Lunsford, Hubert M. Tse, Gerald G. McGwin, Kenneth L. McCormick   +6 more
doaj   +1 more source

Biological characteristics of the enteroaggregative escherichia coli ont:h30 18-726 (no. B-8857) strain isolated from a patient with ulcerative colitis and a new method of pcr identification

Инфекция и иммунитет, 2023
The aim of the work is to assess biological properties of the enteroaggregativeEscherichia coli(EAgEC) strain isolated from the colon mucosa biopsy material from a patient with ulcerative colitis, and to develop a new method for PCR identification ofE ...
Maria A. Makarova, Egor E. Kruglov, Lidia A. Kaftyreva   +2 more
doaj   +1 more source

Evolutionary Profiling of Group II Pyridoxal-Phosphate-Dependent Decarboxylases Suggests Expansion and Functional Diversification of Histidine Decarboxylases in Tomato

The Plant Genome, 2016
Pyridoxal phosphate (PLP)-dependent enzymes are one of the most important enzymes involved in plant N metabolism. Here, we explored the evolution of group II PLP-dependent decarboxylases (PLP_deC), including aromatic L-amino acid decarboxylase, glutamate
Rahul Kumar, Gitanjali Jiwani, Amit Pareek, Thula SravanKumar, Ashima Khurana, Arun K. Sharma   +5 more
doaj   +1 more source

Transaminations catalysed by brain glutamate decarboxylase [PDF]

Biochemical Journal, 1985
In addition to normal decarboxylation of glutamate to 4-aminobutyrate, glutamate decarboxylase from pig brain was shown to catalyse decarboxylation-dependent transamination of L-glutamate and direct transamination of 4-aminobutyrate with pyridoxal 5′-phosphate to yield succinic semialdehyde and pyridoxamine 5′-phosphate in a 1:1 stoichiometric ratio ...
T G, Porter, D C, Spink, S B, Martin, D L, Martin   +3 more
openaire   +2 more sources

Contribution of glutamate decarboxylase in Lactobacillus reuteri to acid resistance and persistence in sourdough fermentation

Microbial Cell Factories, 2011
Background Acid stress impacts the persistence of lactobacilli in industrial sourdough fermentations, and in intestinal ecosystems. However, the contribution of glutamate to acid resistance in lactobacilli has not been demonstrated experimentally, and ...
Gänzle Michael G, Schlicht Sabine, Su Marcia S   +2 more
doaj   +1 more source

Biosynthesis of Polyamide 4, a Biobased and Biodegradable Polymer

Microbiology Indonesia, 2010
Polyamide 4, which is composed of repeating unit of g-aminobutyric acid (GABA), is a biobased and biodegradable polymer since it can be synthesized from renewable material instead of fossil-based material. GABA is produced by decarboxylation of glutamate
IWAN SASKIAWAN
doaj   +1 more source

Metabolic engineering of Escherichia coli for the biosynthesis of 2-pyrrolidone

Metabolic Engineering Communications, 2016
2-Pyrrolidone is a valuable bulk chemical with myriad applications as a solvent, polymer precursor and active pharmaceutical intermediate. A novel 2-pyrrolidone synthase, ORF27, from Streptomyces aizunensis was identified to catalyze the ring closing ...
Jingwei Zhang, Emily Kao, George Wang, Edward E.K. Baidoo, Matthew Chen, Jay. D. Keasling   +5 more
doaj   +1 more source

Response of tyramine and glutamate related signals to nanoplastic exposure in Caenorhabditis elegans

Ecotoxicology and Environmental Safety, 2021
Neurotransmission related signals are involved in the control of response to toxicants. We here focused on the tyramine and the glutamate related signals to determine their roles in regulating nanoplastic toxicity in Caenorhabditis elegans.
Shuting Wang, Huanliang Liu, Man Qu, Dayong Wang   +3 more
doaj   +1 more source