An unexpected role for a glutamate receptor. [PDF]
Science, 2023 γ-Aminobutyric acid acts on a glutamate receptor, evoking synaptic ...
Coombs ID, Farrant M.
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The Role of Glutamate Receptors in Epilepsy
Biomedicines, 2023 Glutamate is an essential excitatory neurotransmitter in the central nervous system, playing an indispensable role in neuronal development and memory formation. The dysregulation of glutamate receptors and the glutamatergic system is involved in numerous
Tsang-Shan Chen +3 more
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Multiple serum anti-glutamate receptor antibody levels in clozapine-treated/naïve patients with treatment-resistant schizophrenia. [PDF]
BMC PsychiatryBackground Glutamatergic function abnormalities have been implicated in the etiology of treatment-resistant schizophrenia (TRS), and the efficacy of clozapine may be attributed to its impact on the glutamate system.
He J +12 more
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Interaction of Central Glutamatergic and Histaminergic Systems on Food Intake Regulation in Layer Chickens [PDF]
Archives of Razi Institute, 2021 This study purposed to discover the connection between the central glutamatergic and histaminergic systems on feeding behavior in layer chickens. In the first experiment, chicks obtained intracerebroventricular (ICV) injections of saline (control ...
M Mobarhan Fard +3 more
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PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus
Nature Communications, 2021 Long-term potentiation at hippocampal CA1 synapses can be due to increasing the number and/or single-channel conductance of AMPA receptors. The authors show that PKA and CaMKII are necessary and together sufficient to increase single channel conductance,
Pojeong Park +10 more
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Genomics and transcriptomic alterations of the glutamate receptors in acute myeloid leukemia
Clinical and Translational Science, 2023 Glutamine and glutamate have been widely explored as potential therapeutic targets in acute myeloid leukemia (AML). In addition to its bioenergetic role in leukemia cell proliferation, L‐glutamate is a neurotransmitter that acts on glutamate receptors ...
Amani Alqahtani +3 more
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Glutamatergic Mechanisms in Glioblastoma and Tumor-Associated Epilepsy
Cells, 2021 The progression of glioblastomas is associated with a variety of neurological impairments, such as tumor-related epileptic seizures. Seizures are not only a common comorbidity of glioblastoma but often an initial clinical symptom of this cancer entity ...
Falko Lange +2 more
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Comprehensive Insight of Neurodegenerative Diseases and The Role of Neurotoxin Agents — Glutamate
Progress in Microbes and Molecular Biology, 2020 The increased concentration of extracellular glutamate has been reported to play a key role in most of the neurodegenerative diseases, such as Parkinson’s disease and Alzheimer’s disease, even though its importance as an amino acid neurotransmitter in ...
Hui-Min Yap +2 more
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Regulation of dopamine D1 receptor dynamics within the postsynaptic density of hippocampal glutamate synapses. [PDF]
PLoS ONE, 2013 Dopamine receptor potently modulates glutamate signalling, synaptic plasticity and neuronal network adaptations in various pathophysiological processes. Although key intracellular signalling cascades have been identified, the cellular mechanism by which ...
Laurent Ladepeche +3 more
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Magnesium sulfate protects against the bioenergetic consequences of chronic glutamate receptor stimulation. [PDF]
PLoS ONE, 2013 Extracellular glutamate is elevated following brain ischemia or trauma and contributes to neuronal injury. We tested the hypothesis that magnesium sulfate (MgSO4, 3 mM) protects against metabolic failure caused by excitotoxic glutamate exposure.
Pascaline Clerc +5 more
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