The Role of Glutamate Receptors in Epilepsy
Biomedicines, 2023 Glutamate is an essential excitatory neurotransmitter in the central nervous system, playing an indispensable role in neuronal development and memory formation. The dysregulation of glutamate receptors and the glutamatergic system is involved in numerous
Tsang-Shan Chen +3 more
doaj +4 more sources
Long-Term Exposure to 6-PPD Quinone Inhibits Glutamate Synthesis and Glutamate Receptor Function Associated with Its Toxicity Induction in Caenorhabditis elegans [PDF]
Toxics6-PPD quinone (6-PPDQ) is widely distributed in environments. In Caenorhabditis elegans, we first examined the effects of 6-PPDQ on glutamate synthesis and receptor function by analyzing glutamate content, related gene expression, and phenotypes after ...
Wei Wang, Yunhui Li, Dayong Wang
doaj +2 more sources
Multiple serum anti-glutamate receptor antibody levels in clozapine-treated/naïve patients with treatment-resistant schizophrenia [PDF]
BMC PsychiatryBackground Glutamatergic function abnormalities have been implicated in the etiology of treatment-resistant schizophrenia (TRS), and the efficacy of clozapine may be attributed to its impact on the glutamate system.
Jingqi He +12 more
doaj +2 more sources
Interaction of Central Glutamatergic and Histaminergic Systems on Food Intake Regulation in Layer Chickens [PDF]
Archives of Razi Institute, 2021 This study purposed to discover the connection between the central glutamatergic and histaminergic systems on feeding behavior in layer chickens. In the first experiment, chicks obtained intracerebroventricular (ICV) injections of saline (control ...
M Mobarhan Fard +3 more
doaj +1 more source
Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels
Pharmacological Reviews, 2021 Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the mammalian central nervous system, are mediated via signaling by ionotropic glutamate receptors (iGluRs).
K. Hansen +18 more
semanticscholar +1 more source
PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus
Nature Communications, 2021 Long-term potentiation at hippocampal CA1 synapses can be due to increasing the number and/or single-channel conductance of AMPA receptors. The authors show that PKA and CaMKII are necessary and together sufficient to increase single channel conductance,
Pojeong Park +10 more
doaj +1 more source
Genomics and transcriptomic alterations of the glutamate receptors in acute myeloid leukemia
Clinical and Translational Science, 2023 Glutamine and glutamate have been widely explored as potential therapeutic targets in acute myeloid leukemia (AML). In addition to its bioenergetic role in leukemia cell proliferation, L‐glutamate is a neurotransmitter that acts on glutamate receptors ...
Amani Alqahtani +3 more
doaj +1 more source
Glutamatergic Mechanisms in Glioblastoma and Tumor-Associated Epilepsy
Cells, 2021 The progression of glioblastomas is associated with a variety of neurological impairments, such as tumor-related epileptic seizures. Seizures are not only a common comorbidity of glioblastoma but often an initial clinical symptom of this cancer entity ...
Falko Lange +2 more
doaj +1 more source
Linking glutamate receptor movements and synapse function
Science, 2020 Receptors moving in and out of the synapse The number of neurotransmitter receptors and their spatial organization on the postsynaptic site is a central determinant of synaptic efficacy.
L. Groc, D. Choquet
semanticscholar +1 more source
Comprehensive Insight of Neurodegenerative Diseases and The Role of Neurotoxin Agents — Glutamate
Progress in Microbes and Molecular Biology, 2020 The increased concentration of extracellular glutamate has been reported to play a key role in most of the neurodegenerative diseases, such as Parkinson’s disease and Alzheimer’s disease, even though its importance as an amino acid neurotransmitter in ...
Hui-Min Yap +2 more
doaj +1 more source