Results 1 to 10 of about 381,975 (358)

Glutamate receptor expression and chronic glutamate toxicity in rat motor cortex

open access: yesNeurobiology of Disease, 2007
In addition to the loss of spinal motor neurons, amyotrophic lateral sclerosis (ALS) is also associated with degeneration of corticospinal layer V pyramidal neurons and decreased glutamate transport in the cortex. We characterized the glutamate receptors
Kate C. Young   +2 more
doaj   +1 more source

A Mathematical Model of Tripartite Synapse: Astrocyte Induced Synaptic Plasticity

open access: yes, 2012
In this paper we present a biologically detailed mathematical model of tripartite synapses, where astrocytes modulate short-term synaptic plasticity. The model consists of a pre-synaptic bouton, a post-synaptic dendritic spine-head, a synaptic cleft and ...
Majumdar, Kaushik, Tewari, Shivendra
core   +1 more source

Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4 [PDF]

open access: hybrid, 1993
Yasuto Tanabe   +5 more
openalex   +1 more source

Kainate-induced status epilepticus alters glutamate and GABAA receptor gene expression in adult rat hippocampus: an in situ hybridization study [PDF]

open access: hybrid, 1994
LK Friedman   +5 more
openalex   +1 more source

Posttranslational Nitration of Tyrosine Residues Modulates Glutamate Transmission and Contributes to N-Methyl-D-aspartate-Mediated Thermal Hyperalgesia

open access: yesMediators of Inflammation, 2013
Activation of the N-methyl-D-aspartate receptor (NMDAR) is fundamental in the development of hyperalgesia. Overactivation of this receptor releases superoxide and nitric oxide that, in turn, forms peroxynitrite (PN).
Carolina Muscoli   +8 more
doaj   +1 more source

Crosstalk Between Brain-Derived Neurotrophic Factor And N-Methyl-D-Aspartate Receptor Signaling In Neurons [PDF]

open access: yes, 2008
Glutamate is the major excitatory neurotransmitter in brain exerting prosurvival effect on neurons via N-methyl-D-aspartate receptor (NMDAR) signaling under physiological conditions.
Georgiev, Danko   +3 more
core  

Cyclic AMP and synaptic activity-dependent phosphorylation of AMPA- preferring glutamate receptors [PDF]

open access: hybrid, 1994
Craig Blackstone   +4 more
openalex   +1 more source

Binge drinking triggers VGLUT3-mediated glutamate secretion and subsequent hepatic inflammation by activating mGluR5/NOX2 in Kupffer cells

open access: yesNature Communications
Glutamate, a crucial player in hepatic amino acid metabolism, has been relatively unexplored in immune cell activation. We show in a study with male mice that hepatic glutamate accumulates in vesicles of perivenous hepatocytes through vesicular glutamate
Keungmo Yang   +21 more
doaj   +1 more source

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