Results 1 to 10 of about 224,849 (162)

Interaction of Central Glutamatergic and Histaminergic Systems on Food Intake Regulation in Layer Chickens [PDF]

Archives of Razi Institute, 2021
This study purposed to discover the connection between the central glutamatergic and histaminergic systems on feeding behavior in layer chickens. In the first experiment, chicks obtained intracerebroventricular (ICV) injections of saline (control ...
M Mobarhan Fard, B Vazir, M Zendehdel, A Asghari   +3 more
doaj   +1 more source

PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus

Nature Communications, 2021
Long-term potentiation at hippocampal CA1 synapses can be due to increasing the number and/or single-channel conductance of AMPA receptors. The authors show that PKA and CaMKII are necessary and together sufficient to increase single channel conductance,
Pojeong Park, John Georgiou, Thomas M. Sanderson, Kwang-Hee Ko, Heather Kang, Ji-il Kim, Clarrisa A. Bradley, Zuner A. Bortolotto, Min Zhuo, Bong-Kiun Kaang, Graham L. Collingridge   +10 more
doaj   +1 more source

Genomics and transcriptomic alterations of the glutamate receptors in acute myeloid leukemia

Clinical and Translational Science, 2023
Glutamine and glutamate have been widely explored as potential therapeutic targets in acute myeloid leukemia (AML). In addition to its bioenergetic role in leukemia cell proliferation, L‐glutamate is a neurotransmitter that acts on glutamate receptors ...
Amani Alqahtani, Mengxi Wang, Mimi Lou, Houda Alachkar   +3 more
doaj   +1 more source

Glutamatergic Mechanisms in Glioblastoma and Tumor-Associated Epilepsy

Cells, 2021
The progression of glioblastomas is associated with a variety of neurological impairments, such as tumor-related epileptic seizures. Seizures are not only a common comorbidity of glioblastoma but often an initial clinical symptom of this cancer entity ...
Falko Lange, Max Frederik Hörnschemeyer, Timo Kirschstein   +2 more
doaj   +1 more source

(2,6)- and (2,6)-hydroxynorketamine inhibit the induction of NMDA receptor-dependent LTP at hippocampal CA1 synapses in mice

Brain and Neuroscience Advances, 2020
The ketamine metabolite (2 R ,6 R )-hydroxynorketamine has been proposed to have rapid and persistent antidepressant actions in rodents, but its mechanism of action is controversial.
Heather Kang, Pojeong Park, Muchun Han, Patrick Tidball, John Georgiou, Zuner A. Bortolotto, David Lodge, Bong-Kiun Kaang, Graham L. Collingridge   +8 more
doaj   +1 more source

Comprehensive Insight of Neurodegenerative Diseases and The Role of Neurotoxin Agents — Glutamate

Progress in Microbes and Molecular Biology, 2020
The increased concentration of extracellular glutamate has been reported to play a key role in most of the neurodegenerative diseases, such as Parkinson’s disease and Alzheimer’s disease, even though its importance as an amino acid neurotransmitter in ...
Hui-Min Yap, Kwan-Liang Lye, Loh Teng-Hern Tan   +2 more
doaj   +1 more source

Regulation of dopamine D1 receptor dynamics within the postsynaptic density of hippocampal glutamate synapses. [PDF]

PLoS ONE, 2013
Dopamine receptor potently modulates glutamate signalling, synaptic plasticity and neuronal network adaptations in various pathophysiological processes. Although key intracellular signalling cascades have been identified, the cellular mechanism by which ...
Laurent Ladepeche, Luting Yang, Delphine Bouchet, Laurent Groc   +3 more
doaj   +1 more source

Magnesium sulfate protects against the bioenergetic consequences of chronic glutamate receptor stimulation. [PDF]

PLoS ONE, 2013
Extracellular glutamate is elevated following brain ischemia or trauma and contributes to neuronal injury. We tested the hypothesis that magnesium sulfate (MgSO4, 3 mM) protects against metabolic failure caused by excitotoxic glutamate exposure.
Pascaline Clerc, Christina A Young, Evan A Bordt, Alina M Grigore, Gary Fiskum, Brian M Polster   +5 more
doaj   +1 more source

Peripheral N-methyl-d-aspartate receptor activation contributes to monosodium glutamate-induced headache but not nausea behaviours in rats

Scientific Reports, 2022
Monosodium glutamate induces behaviors thought to reflect headache and nausea in rats. We explored the effects of the N-methyl-d-aspartate receptor antagonist (2R)-amino-5-phosphonovaleric acid, the inotropic glutamate receptor antagonist kynurenic acid,
Tarique Benbow, Felisha Teja, Afrooz Sheikhi, Fernando G. Exposto, Peter Svensson, Brian E. Cairns   +5 more
doaj   +1 more source

A Glio-Protective Role of mir-263a by Tuning Sensitivity to Glutamate

Cell Reports, 2017
Glutamate is a ubiquitous neurotransmitter, mediating information flow between neurons. Defects in the regulation of glutamatergic transmission can result in glutamate toxicity, which is associated with neurodegeneration.
Sherry Shiying Aw, Isaac Kok Hwee Lim, Melissa Xue Mei Tang, Stephen Michael Cohen   +3 more
doaj   +1 more source