An unexpected role for a glutamate receptor. [PDF]
γ-Aminobutyric acid acts on a glutamate receptor, evoking synaptic ...
Coombs ID, Farrant M.
europepmc +4 more sources
mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism. [PDF]
Metabotropic glutamate receptor 5 (mGluR5) antagonism inhibits cocaine self-administration and reinstatement of drug-seeking behavior. However, the cellular and molecular mechanisms underlying this action are poorly understood.
Bi, Guo-Hua+9 more
core +2 more sources
Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor [PDF]
L-glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and plays a fundamental role in the control of motor function, cognition and mood.
Grove, Simon J .A.+4 more
core +1 more source
Differential localization of glutamate receptor subunits at the drosophila neuromuscular junction [PDF]
The subunit composition of postsynaptic neurotransmitter receptors is a key determinant of synaptic physiology. Two glutamate receptor subunits, Drosophila glutamate receptor IIA (DGluRIIA) and DGluRIIB, are expressed at the Drosophila neuromuscular ...
Allen, Marcus James+4 more
core +1 more source
Mechanisms associated with activation of intracellular metabotropic glutamate receptor, mGluR5 [PDF]
The group 1 metabotropic glutamate receptor, mGluR5, is found on the cell surface as well as on intracellular membranes where it can mediate both overlapping and unique signaling effects.
Jong, Yuh-Jiin I, O\u27Malley, Karen L
core +2 more sources
Inhibition of Food Intake by PACAP in the Hypothalamic Ventromedial Nuclei is Mediated by NMDA Receptors [PDF]
Central injections of pituitary adenylate cyclase-activating polypeptide (PACAP) into the ventromedial nuclei (VMN) of the hypothalamus produce hypophagia that is dependent upon the PAC1 receptor; however, the signaling downstream of this receptor in the
Choi, Sujean+3 more
core +2 more sources
Glutamate Receptors in Plants [PDF]
Ionotropic glutamate receptors function in animals as glutamate-gated non-selective cation channels. Numerous glutamate receptor-like (GLR) genes have been identified in plant genomes, and plant GLRs are predicted, on the basis of sequence homology, to retain ligand-binding and ion channel activity. Non-selective cation channels are ubiquitous in plant
openaire +3 more sources
Glutamatergic transmission in the central nucleus of the amygdala is selectively altered in Marchigian Sardinian alcohol-preferring rats: Alcohol and CRF effects [PDF]
The CRF system of the central nucleus of the amygdala (CeA) is important for the processing of anxiety, stress, and effects of acute and chronic ethanol.
CICCOCIOPPO, Roberto+7 more
core +1 more source
Glutamate and its receptors in cancer [PDF]
Glutamate, a nonessential amino acid, is a major bioenergetic substrate for proliferating normal and neoplastic cells on one hand and an excitatory neurotransmitter that is actively involved in biosynthetic, bioenergetic, metabolic, and oncogenic signaling pathways on the other.
Andrzej Stepulak+3 more
openaire +4 more sources
Dopamine protects neurons against glutamate-induced excitotoxicity [PDF]
Glutamate excitotoxicity is responsible for neuronal death in acute neurological disorders including stroke, trauma and neurodegenerative disease. Loss of calcium homeostasis is a key mediator of glutamate-induced cell death.
Abramov, AY+4 more
core +1 more source