Results 31 to 40 of about 2,983,362 (305)
Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator
Science, 2014 Completing the Set G protein–coupled receptors (GPCRs) are membrane proteins that transduce extracellular signals to activate diverse signaling pathways. Significant insight into GPCR function has come from structures of three of four classes of GPCRs—A,
Huixian Wu +12 more
semanticscholar +1 more source
AMPA and Kainate Receptors Each Mediate Excitotoxicity in Oligodendroglial Cultures
Neurobiology of Disease, 1999 Recent studies indicate that oligodendrocytes are vulnerable to excitotoxic insults mediated by glutamate receptors. The present study was carried out to characterize the type of glutamate receptors triggering cell death in optic nerve oligodendrocyte ...
Maria Victoria Sánchez-Gómez +1 more
doaj +1 more source
Glutamate receptors in the kidney [PDF]
Nephrology Dialysis Transplantation, 2015 l-Glutamate (l-Glu) plays an essential role in the central nervous system (CNS) as an excitatory neurotransmitter, and exerts its effects by acting on a large number of ionotropic and metabotropic receptors. These receptors are also expressed in several peripheral tissues, including the kidney.
openaire +2 more sources
Nature Communications, 2021 Here, the authors use smFRET to assess the structural dynamics of metabotropic glutamate receptor mGlu2 and show that a positive allosteric modulator or the Gi protein stabilize mGlu2 in the glutamate-induced active state, leading to the full activation ...
Anne-Marinette Cao +5 more
doaj +1 more source
Bidirectional Control of Synaptic GABAAR Clustering by Glutamate and Calcium
Cell Reports, 2015 GABAergic synaptic transmission regulates brain function by establishing the appropriate excitation-inhibition (E/I) balance in neural circuits.
Hiroko Bannai +9 more
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Possible Role of N-Methyl-D-Aspartate Glutamate Receptors in The Induction of Acrosome Reaction in Human Sperm [PDF]
Cell JournalObjective: Acrosome reaction is a receptor and Ca2+-dependent process. N-Methyl-D- aspartate (NMDA) glutamatereceptors are expressed in the human sperm and are involved in the Ca2+ influx.
Hamid Reza Momeni +5 more
doaj +1 more source
Glutamate triggers long-distance, calcium-based plant defense signaling
Science, 2018 Rapid, long-distance signaling in plants A plant injured on one leaf by a nibbling insect can alert its other leaves to begin anticipatory defense responses. Working in the model plant Arabidopsis, Toyota et al. show that this systemic signal begins with
M. Toyota +7 more
semanticscholar +1 more source
Structural mechanism of glutamate receptor activation and desensitization
Nature, 2014 Ionotropic glutamate receptors are ligand-gated ion channels that mediate excitatory synaptic transmission in the vertebrate brain. To gain a better understanding of how structural changes gate ion flux across the membrane, we trapped rat AMPA (α-amino-3-
J. Meyerson +7 more
semanticscholar +1 more source
eLife, 2020 Glutamate delta (GluD) receptors belong to the ionotropic glutamate receptor family, yet they don’t bind glutamate and are considered orphan. Progress in defining the ion channel function of GluDs in neurons has been hindered by a lack of pharmacological
Damien Lemoine +7 more
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Glutamate may be an efferent transmitter that elicits inhibition in mouse taste buds. [PDF]
PLoS ONE, 2012 Recent studies suggest that l-glutamate may be an efferent transmitter released from axons innervating taste buds. In this report, we determined the types of ionotropic synaptic glutamate receptors present on taste cells and that underlie this postulated
Yijen A Huang, Jeff Grant, Stephen Roper
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