Results 141 to 150 of about 398,586 (302)

Development of a VHH that inhibits the binding of neuronal pentraxin 2 to a postsynaptic glutamate receptor, AMPAR. [PDF]

J Biol Chem
Yokoo T, Nakakido M, Matsuda K, Caaveiro JMM, Fernandez-Perez J, Yuzaki M, Tsumoto K.   +6 more
europepmc   +1 more source

CB1 Receptor Activation Provides Neuroprotection in an Animal Model of Glutamate‐Induced Excitotoxicity Through a Reduction of NOX‐2 Activity and Oxidative Stress

Ataúlfo Martı́nez-Torres, Julio Morán   +1 more
openalex   +1 more source

Pirin Transcriptionally Regulates PLA2G4A To Inhibit Ferroptosis in Colorectal Cancer via Lipid Profile Remodeling

Advanced Science, EarlyView.
This study identifies Pirin (PIR), an iron‐binding protein, as a critical ferroptosis suppressor in colorectal cancer through lipid membrane remodeling. PIR, induced by NRF2 during ferroptotic stress, transcriptionally regulates PLA2G4A to shift cellular lipid composition away from ferroptosis‐permissive polyunsaturated phospholipids.
Wei Shi, Yue Qi Ong, Prativa Majee, Esther SM Wong, Amhed Missael Vargas Velazquez, Kerem Fidan, Pierce Kah‐Hoe Chow, Wai Leong Tam, Ker Kan Tan, Iain Beehuat Tan, Vinay Tergaonkar   +10 more
wiley   +1 more source

The glutamate receptor-like GLR2.7 modulates insect egg-induced defense responses in Arabidopsis. [PDF]

New Phytol
Mineiro M, Groux R, Gouhier-Darimont C, Mateo P, Robert CAM, Reymond P.   +5 more
europepmc   +1 more source

Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer’s disease: a multi-tracer PET study [PDF]

Elaheh Salardini, Ryan S. O’Dell, Em Tchorz, Nabeel Nabulsi, Yiyun Huang, Richard E. Carson, Christopher H van Dyck, Adam P. Mecca   +7 more
openalex   +1 more source

5‐HT _1B receptors inhibit glutamate release from primary afferent terminals in rat medullary dorsal horn neurons [PDF]

, 2012
I‐S Choi, J‐H Cho, C‐H An, J.–C. Jung, Y‐K Hur, J‐K Choi, I‐S Jang   +6 more
openalex   +1 more source

GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer

Advanced Science, EarlyView.
Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello, Sandra Hauser, Michael Seifert, Christopher K. Barlow, Joel R. Steele, Emma Salisbury, Daniel Croagh, Kathryn S. Stok, Anna V. Taubenberger, Ralf B. Schittenhelm, Daniela Loessner   +10 more
wiley   +1 more source

Human primary skeletal muscle cells express glutamate receptor GluR3, are activated by glutamate, and are affected by autoimmune GluR3B antibodies of epilepsy patients. [PDF]

Front Physiol
Levite M, Ilouz N, Harazi A, Goldberg-Stern H, Galun E, Mitrani-Rosenbaum S.   +5 more
europepmc   +1 more source

Reduction of Glutamatergic Neurotransmission by Prolonged Exposure to Dieldrin Involves NMDA Receptor Internalization and Metabotropic Glutamate Receptor 5 Downregulation [PDF]

, 2009
Víctor Briz, Mireia Galofré, Cristina Suñol   +2 more
openalex   +1 more source

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source