Results 201 to 210 of about 353,061 (312)

Galactose‐Functionalized Gold Nanoparticles Targeting Membrane Transporters for the Glutathione Delivery to Brain Cancer Cells

ChemBioChem, Accepted Article.
Glutathione (GSH), a tripeptide essential for maintaining redox balance in the human body, plays a critical role in protecting cells from oxidative stress. A deficiency in GSH is linked to increased oxidative damage and the progression of various disorders, including cancer and neurological diseases.
Francesca Milano, Alessia Nito, Annalisa Caputo, Antonio Gaballo, Marco Marradi, Alessandra Quarta, Andrea Ragusa   +6 more
wiley   +1 more source

Metabotropic Glutamate Receptor 5 as a Potential Biomarker of the Intersection of Trauma and Cannabis Use. [PDF]

Int J Neuropsychopharmacol
Weiss ER, Davis MT, Asch RH, D'Souza DC, Cool R, Esterlis I.   +5 more
europepmc   +1 more source

Mammalian Tolerance to Amino Acid Heterochirality

ChemBioChem, Accepted Article.
Organisms use amino acids predominantly in l‐configuration. On the other hand, a series of studies show that a variety of d‐amino acids also occur in mammals and amino acid homochirality is not complete. Mammals de novo synthesize most amino acids with l‐configuration, but serine and aspartate are converted from l‐ to d‐configuration by endogenous ...
Jumpei Sasabe, Sakiko Taniguchi, Kenichiro Adachi, Xuan Tran, Masataka Suzuki   +4 more
wiley   +1 more source

A Scoping Review of Corticosterone-Induced Changes in Ionotropic Glutamate Receptor Levels and Localization in the Rodent Brain: Implications for the Auditory System. [PDF]

Brain Sci
Edlund E, Domarecka E, Olze H, Szczepek A.   +3 more
europepmc   +1 more source

Acetylation‐Deacetylation‐Driven Natural Product Biosynthesis

ChemistryEurope, EarlyView.
This review summarizes the role of acetylation‐deacetylation in natural product biosynthesis, including acetylation followed by deacetylation after several biosynthetic steps, acetylation‐mediated rearrangement, acetylation‐triggered elimination, and the acetylation cycle as a regulatory mechanism. These processes are vital for the formation of complex
Huibin Wang, Ikuro Abe
wiley   +1 more source

Inhibition of metabotropic glutamate receptor-5 alleviates hepatic steatosis by enhancing autophagy <i>via</i> activation of the AMPK signaling pathway. [PDF]

World J Gastroenterol
Tao M, Zhang LL, Zhou GH, Wang C, Luo X.
europepmc   +1 more source

Affinity‐Based Protein Profiling Reveals IDH2 as a Mitochondrial Target of Cannabinol in Receptor‐Independent Neuroprotection

Chemistry – A European Journal, EarlyView.
A chemical probe CBN‐P based on the neuroprotective cannabinoid cannabinol (CBN) was developed and synthesized. CNB‐P was found to have a similar mechanism of action as the parent compound and was used in click‐CLEM microscopy studies and affinity‐based protein profiling to identify the mitochondrial protein isocitrate dehydrogenase 2 (IDH2) as one ...
Eva Schaller, Stephanie Lamer, Andreas Schlosser, Christian Stigloher, Pamela Maher, Michael Decker   +5 more
wiley   +1 more source

Activation of Endoplasmic Reticulum-Localized Metabotropic Glutamate Receptor 5 (mGlu₅) Triggers Calcium Release Distinct from Cell Surface Counterparts in Striatal Neurons. [PDF]

Biomolecules
Jong YI, Harmon SK, O'Malley KL.
europepmc   +1 more source

A Ketol‐Acid Reductoisomerase Inhibitor That Has Antituberculosis and Herbicidal Activity

Chemistry – A European Journal, EarlyView.
1a and 1f are potent inhibitors of ketolacid reductoisomerase (KARI). 1f has good antituberculosis activity and 1a has herbicidal activity against Brassica campestris and Amaranthus retroflexus. Abstract Ketol‐acid reductoisomerase (KARI) is a target for the development of new biocidal agents. This is based on its essential role in branched chain amino
Xin Lin, Julia L. Kurz, Yong‐Hong Li, Shun Jie Wun, Thierry Lonhienne, Ross P. McGeary, Nicholas P. West, Gerhard Schenk, Jian‐Guo Wang, Luke W. Guddat   +9 more
wiley   +1 more source