Results 201 to 210 of about 396,749 (354)

Leveraging 3D Molecular Spatial Visual Information and Multi‐Perspective Representations for Drug Discovery

Advanced Science, EarlyView.
A deep learning framework called MolVisGNN is proposed to fuse 3D molecular visual information of drugs with multi‐source features, which proves the importance of 3D molecular visual information of drugs and the advancedness of this model in the field of drug discovery, and provides a reference for how to more comprehensively express small molecule ...
Zimai Zhang, Xi Zhou, Yujie Qi, Xiaobo Zhu, Xun Deng, Feng Tan, Yuan Huang, Lun Hu, Zhuhong You, Pengwei Hu   +9 more
wiley   +1 more source

Apo-state structure of the metabotropic glutamate receptor 5 transmembrane domain obtained using a photoswitchable ligand. [PDF]

Protein Sci
Kondo Y, Hatton C, Cheng R, Trabuco M, Glover H, Bertrand Q, Stierli F, Seidel HP, Mason T, Sarma S, Tellkamp F, Kepa M, Dworkowski F, Mehrabi P, Hennig M, Standfuss J.   +15 more
europepmc   +1 more source

Effects of glutamate receptor agonists and antagonists on NRG1 release.

, 2017
Yuriko Iwakura, Ran Wang, Naoko Inamura, Kazuaki Araki, Shigeki Higashiyama, Nobuyuki Takei, Hiroyuki Nawa   +6 more
openalex   +2 more sources

In vivo pathway of thermal hyperalgesia by intrathecal administration of α,β‐methylene ATP in mouse spinal cord: Involvement of the glutamate‐NMDA receptor system [PDF]

, 1999
Makoto Tsuda, Shinya Ueno, Kazuhide Inoue   +2 more
openalex   +1 more source

Photoswitchable allosteric modulators for metabotropic glutamate receptors

, 2022
Xavier Gómez‐Santacana, Silvia Panarello, Xavier Rovira, Amadeu Llebaria   +3 more
openalex   +1 more source

Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S‐Adenosylmethionine Cycle

Advanced Science, EarlyView.
USP30 deubiquitinates and stabilizes MAT2A, thereby regulating DNA methylation and miRNA expression, which ultimately leads to disruption of lung endothelial barrier and inflammation. Abstract Microvascular dysfunction is a key contributor to the development of acute inflammatory diseases, characterized by heightened vascular hyperpermeability and ...
Baoyinna Baoyinna, Jinshan He, Jiaxing Miao, Nargis Shaheen, Boyu Xia, Cankun Wang, Qin Ma, Matthew C Bernier, Bryan A Whitson, Nuo Sun, Jing Zhao, Yutong Zhao   +11 more
wiley   +1 more source

Acute Alcohol-Induced Changes Measured With Metabotropic Glutamate Receptor 5 Positron Emission Tomography. [PDF]

Addict Biol
Raval NR, Smart K, Angarita GA, Miller R, Huang Y, Krystal JH, Carson RE, Cosgrove KP, O'Malley SS, Hillmer AT.   +9 more
europepmc   +1 more source

International Union of Basic and Clinical Pharmacology. CXI. Pharmacology, Signaling, and Physiology of Metabotropic Glutamate Receptors [PDF]

, 2020
Karen J. Gregory, Cyril Goudet
openalex   +1 more source

A Dynamic Gate Enables Regioselective Hydroxylation of Free Arginine by a Non‐Canonical Heme Enzyme

Advanced Science, EarlyView.
The YqcI/YcgG enzyme AglA employs a unique “sandwich” fold and a dynamic gating mechanism to selectively hydroxylate AMPn‐Arg at Nε. Site‐directed mutations reprogram regioselectivity or enable activity on free arginine by altering hydrogen‐bond networks, precisely positioning substrates.
Yuan Sun, Chao Dou, Weizhu Yan, Pengpeng Chen, Lu Zhang, Dan Zhou, Yanhui Zheng, Zhaolin Long, Shoujie Li, Xiaoqing Xu, Qiuxia Huang, Xiaofeng Zhu, Wei Cheng   +12 more
wiley   +1 more source

Metabotropic glutamate receptor 4-mediated glutamatfergic signaling reshapes the tumor microenvironment by regulating dendritic cell maturation. [PDF]

Nat Commun
Ju X, Putz EM, Liu Y, Yuan D, Sun G, Koda S, Fu Z, Shao S, Tong C, Deng B, Hu J, Yan J.   +11 more
europepmc   +1 more source