Results 211 to 220 of about 398,586 (302)

Non‐Synaptic Function and Localization of Syntaxin‐Binding Protein 1 in a Mouse Model of STXBP1‐Related Epileptic Encephalopathy

Annals of Neurology, EarlyView.
Objective De novo mutations in the syntaxin‐binding protein 1 (STXBP1), encoded by STXBP1, are among the most prevalent causes of variable neurodevelopmental disorders, including epileptic encephalopathy, developmental delay, and movement disorders.
Tao Yang, Rajat Banerjee, Yamei Deng, Sheetal Jahagirdar1, Alexey I. Nesvizhskii, Michael D. Uhler, Jack M. Parent, Yu Wang   +7 more
wiley   +1 more source

A Novel Acetylcholine Nanosensor for Single Vesicle Storage and Sub‐Quantal Exocytosis in Living Neurons and Organoids

Angewandte Chemie, EarlyView.
Schematic representation of M@E@CF nanosensors for detecting vesicular storage and release in cholinergic neurons and brain organoids. (A) Nano‐tip microelectrodes modification via molds fabricated through 3D printing. (B) the reaction mechanism for acetylcholine detection at the electrode interface.
Wanying Zhu, Yufan Zhang, Hanwen Yu, Da Wang, Xinyue Zhang, Xiaowen Du, Shanshan Wu, Bingzhi Li, Yizhou Zhang, Hongliang Xin, Xing Guo, Yan Liu   +11 more
wiley   +2 more sources

Agonism of the glutamate receptor GluK2 suppresses dermal mast cell activation and cutaneous inflammation. [PDF]

Sci Transl Med
Zhang YR, Keshari S, Kurihara K, Liu J, McKendrick LM, Chen CS, Yang Y, Falo LD, Das J, Sumpter TL, Kaplan DH.   +10 more
europepmc   +1 more source

Gene expression of metabotropic glutamate receptors and histone deacetylases in postmortem prefrontal cortex of subjects with bipolar disorder

I. Bonis, J.A. Santas, Benito Morentín, Luís F. Callado, J. Javier Meana, Elisabet Vilella, Alfredo Ramos‐Miguel, Guadalupe Rivero   +7 more
openalex   +1 more source

Hydroxycarboxylic Acid Receptor 2 Mediates β‐hydroxybutyrate's Antiseizure Effect in Mice

Annals of Neurology, EarlyView.
A Objective The ketogenic diet, a high‐fat, low‐carbohydrate regimen, is often used to treat drug‐resistant seizures and is being studied for Alzheimer's disease and other neuropsychiatric disorders. However, its mechanism of action remains unclear. β‐hydroxybutyrate, a primary circulating ketone body produced by the ketogenic diet, may mediate its ...
Soudabeh Naderi, John Williamson, Huayu Sun, Suchitra Joshi, Rachel Jane Spera, Savaira Zaib, Supriya Sharma, Chengsan Sun, Andrey Brodovskiy, Ifrah Zawar, Jaideep Kapur   +10 more
wiley   +1 more source

Tau pathology is associated with postsynaptic metabotropic glutamate receptor 5 (mGluR5) in early Alzheimer's disease in a sex-specific manner. [PDF]

Alzheimers Dement
Wang Y, Wang J, Chen X, Lin Z, You Z, He K, Guo T, Zhao J, Huang Q, Ni R, Guan Y, Li B, Xie F.   +12 more
europepmc   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Differing Patterns of Ionotropic Glutamate Receptor Subunit Gene Expression in Paraventricular Hypothalamic Nucleus Subregions following Angiotensin II Hypertension in Male Mice and Female Mice with Advanced Ovarian Failure.

Neuroendocrinology
Sommer G, Hussein SO, Milner TA, Glass MJ.   +3 more
europepmc   +1 more source

Spontaneous partial resolution of autoimmune-mediated brain MRI abnormalities before immunotherapy in anti-metabotropic glutamate receptor 5 encephalitis: a case report. [PDF]

Front Immunol
Chen J, Tang X, Wang L, Guo D, Cao L, Lu K.   +5 more
europepmc   +1 more source

Cold sensing by a glutamate receptor drives avoidance behavior in Drosophila larvae [PDF]

Liang Xu, Hyun-Joon Son, Xu Bai, Ruonan Li, Elizabeth A. Ronan, Gun-Ho Kim, Bing Ye   +6 more
openalex   +1 more source