Results 221 to 230 of about 353,061 (312)

Mechanical unloading is accompanied by reverse metabolic remodelling in the failing heart: Identification of a novel citraconate‐mediated pathway

European Journal of Heart Failure, EarlyView.
Aims Although functional recovery of the failing heart with left ventricular assist device (LVAD) unloading can occur, the underpinning mechanism is unclear. We aimed to characterize the effect of myocardial biochemical effect of LVAD support in vivo and in vitro.
David M. Kaye, Xiao Suo Wang, Yen Chin Koay, Mengbo Li, Bailey McIntosh, Yann Huey Ng, Michael Rahman, Yiyang Cao, Francine Z. Marques, Cassandra Malecki, Shane Nanayakarra, Justin Mariani, Bing Wang, Sean Lal, Giovanni Guglielmi, John F. O'Sullivan   +15 more
wiley   +1 more source

Correction for Wu et al., NR2B subunit of the NMDA glutamate receptor regulates appetite in the parabrachial nucleus. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

Enigmatic intractable Epilepsy patients have antibodies that bind glutamate receptor peptides, kill neurons, damage the brain, and cause Generalized Tonic Clonic Seizures. [PDF]

J Neural Transm (Vienna)
Taiwo RO, Goldberg HS, Ilouz N, Singh PK, Shekh-Ahmad T, Levite M.   +5 more
europepmc   +1 more source

Benzochalcogenodiazoles, Synthesis, and Applications in Medicinal Chemistry and Photomedicine

European Journal of Organic Chemistry, EarlyView.
Benzochalcogenodiazoles (BXD) including benzoxadiazoles, benzothiadiazoles, and benzoselenadiazoles are initially mainly designed for optoelectronic materials as electron‐deficient cores. Nevertheless, they are now extending their application to biology.
Jean‐Elie Zheng, Xavier Franck, Thibault Gallavardin   +2 more
wiley   +1 more source

Radiosynthesis and preclinical evaluation of a carbon-11 labeled PET ligand for imaging metabotropic glutamate receptor 7. [PDF]

Am J Nucl Med Mol Imaging
Li Y, Xiao Z, Mori W, Sun J, Yamasaki T, Rong J, Fujinaga M, Chen J, Kumata K, Zhao C, Zhang Y, Collier TL, Hu K, Xie L, Zhou X, Zhang W, Song Z, Gao Y, Sun Z, Zhang K, Patel JS, Ran C, Chaudhary A, Sheffler DJ, Cosford ND, Zhang L, Zhai C, Haider A, Yuan H, Zhang MR, Liang SH.   +30 more
europepmc   +1 more source

Discovery of 4-(5-Membered)Heteroarylether-6-methylpicolinamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5. [PDF]

ACS Med Chem Lett
Childress ES, Capstick RA, Crocker KE, Ledyard ML, Bender AM, Maurer MA, Billard NB, Cho HP, Rodriguez AL, Niswender CM, Peng W, Rook JM, Chang S, Blobaum AL, Boutaud O, Thompson Gray A, Jones CK, Conn PJ, Felts AS, Lindsley CW, Temple KJ.   +20 more
europepmc   +1 more source

Activation of nociception-sensitive ionotropic glutamate receptor-expressing rostroventrolateral medulla neurons by stimulation of cardiac afferents in rats. [PDF]

FASEB Bioadv
Zahner MR, Oculam CC, Beaumont E.
europepmc   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Investigation of the Roles of the Adenosine A(2A) and Metabotropic Glutamate Receptor Type 5 (mGlu5) Receptors in Prepulse Inhibition and CREB Signaling in a Heritable Rodent Model of Psychosis. [PDF]

Cells
Cuozzo AM, Peeters LD, Ahmed CD, Wills LJ, Gass JT, Brown RW.   +5 more
europepmc   +1 more source

Polypharmacy with tiagabine, levetiracetam, and perampanel in status epilepticus: Insights from EEG, biochemical, and histopathological studies in rats

Epilepsia Open, EarlyView.
Abstract Objective Status epilepticus (SE) is a condition of neurological emergency, which precipitates various functional and morphological changes in the brain. Due to the risk of drug resistance associated with SE, this study aimed to evaluate a multitargeted approach to treat SE by combining clinically used antiseizure drugs. Methods In this study,
Sana Javaid, Faleh Alqahtani, Abida Parveen, Waseem Ashraf, Zohabia Rehman, Syed Muhammad Muneeb Anjum, Tanveer Ahmad, Imran Imran   +7 more
wiley   +1 more source