Effect of glutamate antagonists on nitric oxide production in rat brain following intrahippocampal injection [PDF]
Archives of Biological Sciences, 2007 Stimulation of glutamate receptors induces neuronal nitric oxide (NO) release, which in turn modulates glutamate transmission. The involvement of ionotropic glutamate NMDA and AMPA/kainate receptors in induction of NO production in the rat brain was ...
Radenović Lidija +3 more
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Chimeric glutamate receptor subunits reveal the transmembrane domain is sufficient for NMDA receptor pore properties but some positive allosteric modulators require additional domains [PDF]
, 2016 NMDA receptors are ligand-gated ion channels that underlie transmission at excitatory synapses and play an important role in regulating synaptic strength and stability.
Huettner, Jmaes E +2 more
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Glutamate receptor pores [PDF]
The Journal of Physiology, 2014 AbstractGlutamate receptors are ligand‐gated ion channels that mediate fast excitatory synaptic transmission throughout the central nervous system. Functional receptors are homo‐ or heteromeric tetramers with each subunit contributing a re‐entrant pore loop that dips into the membrane from the cytoplasmic side. The pore loops form a narrow constriction
openaire +2 more sources
Phased Treatment Strategies for Cerebral Ischemia Based on Glutamate Receptors
Frontiers in Cellular Neuroscience, 2019 Extracellular glutamate accumulation following cerebral ischemia leads to overactivation of glutamate receptors, thereby resulting in intracellular Ca2+ overload and excitotoxic neuronal injury. Multiple attempts have been made to counteract such effects
Yongjun Sun +8 more
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Different Sites of Alcohol Action in the NMDA Receptor GluN2A and GluN2B Subunits [PDF]
, 2015 The NMDA receptor is a major target of alcohol action in the CNS, and recent behavioral and cellular studies have pointed to the importance of the GluN2B subunit in alcohol action.
Allgaier +68 more
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Frontiers in Neuroscience, 2014 The orexin/hypocretin neuropeptides are produced by a cluster of neurons within the lateral posterior hypothalamus and participate in neuronal regulation by activating their receptors (OX1 and OX2 receptors).
Leah eAluisio +8 more
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Modulation of glutamate transport and receptor binding by glutamate receptor antagonists in EAE rat brain. [PDF]
PLoS ONE, 2014 The etiology of multiple sclerosis (MS) is currently unknown. However, one potential mechanism involved in the disease may be excitotoxicity. The elevation of glutamate in cerebrospinal fluid, as well as changes in the expression of glutamate receptors ...
Grzegorz Sulkowski +3 more
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Mechanisms associated with activation of intracellular metabotropic glutamate receptor, mGluR5 [PDF]
, 2016 The group 1 metabotropic glutamate receptor, mGluR5, is found on the cell surface as well as on intracellular membranes where it can mediate both overlapping and unique signaling effects.
Jong, Yuh-Jiin I, O\u27Malley, Karen L
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Synergistic inhibition of survival, proliferation, and migration of U87 cells with a combination of LY341495 and Iressa. [PDF]
PLoS ONE, 2013 Glioblastomas exploit various molecular pathways to promote glutamate- dependent growth by activating the AMPA (2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propanoic acid) receptor, the group II metabotropic glutamate receptor, mGluR, and the epidermal ...
Zarina Yelskaya +5 more
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