Comprehensive Insight of Neurodegenerative Diseases and The Role of Neurotoxin Agents — Glutamate
Progress in Microbes and Molecular Biology, 2020 The increased concentration of extracellular glutamate has been reported to play a key role in most of the neurodegenerative diseases, such as Parkinson’s disease and Alzheimer’s disease, even though its importance as an amino acid neurotransmitter in ...
Hui-Min Yap +2 more
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Regulation of dopamine D1 receptor dynamics within the postsynaptic density of hippocampal glutamate synapses. [PDF]
PLoS ONE, 2013 Dopamine receptor potently modulates glutamate signalling, synaptic plasticity and neuronal network adaptations in various pathophysiological processes. Although key intracellular signalling cascades have been identified, the cellular mechanism by which ...
Laurent Ladepeche +3 more
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Magnesium sulfate protects against the bioenergetic consequences of chronic glutamate receptor stimulation. [PDF]
PLoS ONE, 2013 Extracellular glutamate is elevated following brain ischemia or trauma and contributes to neuronal injury. We tested the hypothesis that magnesium sulfate (MgSO4, 3 mM) protects against metabolic failure caused by excitotoxic glutamate exposure.
Pascaline Clerc +5 more
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Scientific Reports, 2022 Monosodium glutamate induces behaviors thought to reflect headache and nausea in rats. We explored the effects of the N-methyl-d-aspartate receptor antagonist (2R)-amino-5-phosphonovaleric acid, the inotropic glutamate receptor antagonist kynurenic acid,
Tarique Benbow +5 more
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Synaptic NMDA receptors mediate hypoxic excitotoxic death [PDF]
, 2012 Excessive NMDA receptor activation and excitotoxicity underlies pathology in many neuropsychiatric and neurological disorders, including hypoxia/ischemia.
Eisenman, Larry +3 more
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mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism. [PDF]
, 2018 Metabotropic glutamate receptor 5 (mGluR5) antagonism inhibits cocaine self-administration and reinstatement of drug-seeking behavior. However, the cellular and molecular mechanisms underlying this action are poorly understood.
Bi, Guo-Hua +9 more
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Topiramate treatment is neuroprotective and reduces oligodendrocyte loss after cervical spinal cord injury. [PDF]
PLoS ONE, 2012 Excess glutamate release and associated neurotoxicity contributes to cell death after spinal cord injury (SCI). Indeed, delayed administration of glutamate receptor antagonists after SCI in rodents improves tissue sparing and functional recovery. Despite
John C Gensel +3 more
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Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor [PDF]
, 2010 L-glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and plays a fundamental role in the control of motor function, cognition and mood.
Grove, Simon J .A. +4 more
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A Glio-Protective Role of mir-263a by Tuning Sensitivity to Glutamate
Cell Reports, 2017 Glutamate is a ubiquitous neurotransmitter, mediating information flow between neurons. Defects in the regulation of glutamatergic transmission can result in glutamate toxicity, which is associated with neurodegeneration.
Sherry Shiying Aw +3 more
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Differential localization of glutamate receptor subunits at the drosophila neuromuscular junction [PDF]
, 2004 The subunit composition of postsynaptic neurotransmitter receptors is a key determinant of synaptic physiology. Two glutamate receptor subunits, Drosophila glutamate receptor IIA (DGluRIIA) and DGluRIIB, are expressed at the Drosophila neuromuscular ...
Allen, Marcus James +4 more
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