Posttranslational Modification Biology of Glutamate Receptors and Drug Addiction
Frontiers in Neuroanatomy, 2011 Posttranslational covalent modifications of glutamate receptors remain a hot topic. Early studies have established that this family of receptors, including almost all ionotropic and metabotropic glutamate receptor subtypes, undergoes active ...
Li-Min eMao +5 more
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Binding of glutamate to the umami receptor [PDF]
Biophysical Chemistry, 2010 The umami taste receptor is a heterodimer composed of two members of the T1R taste receptor family: T1R1 and T1R3. It detects glutamate in humans, and is a more general amino acid detector in other species. We have constructed homology models of the ligand binding domains of the human umami receptor (based on crystallographic structures of the ...
Lopez Cacales, J. +3 more
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Glutamate, Glutamate Receptors, and Downstream Signaling Pathways [PDF]
International Journal of Biological Sciences, 2013 Glutamate is a nonessential amino acid, a major bioenergetic substrate for proliferating normal and neoplastic cells, and an excitatory neurotransmitter that is actively involved in biosynthetic, bioenergetic, metabolic, and oncogenic signaling pathways. Glutamate signaling activates a family of receptors consisting of metabotropic glutamate receptors (
Stacey S. Willard, Shahriar Koochekpour
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Dopamine protects neurons against glutamate-induced excitotoxicity [PDF]
, 2013 Glutamate excitotoxicity is responsible for neuronal death in acute neurological disorders including stroke, trauma and neurodegenerative disease. Loss of calcium homeostasis is a key mediator of glutamate-induced cell death.
Abramov, AY +4 more
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Glutamate receptors in the kidney [PDF]
Nephrology Dialysis Transplantation, 2015 l-Glutamate (l-Glu) plays an essential role in the central nervous system (CNS) as an excitatory neurotransmitter, and exerts its effects by acting on a large number of ionotropic and metabotropic receptors. These receptors are also expressed in several peripheral tissues, including the kidney.
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Glutamatergic transmission in the central nucleus of the amygdala is selectively altered in Marchigian Sardinian alcohol-preferring rats: Alcohol and CRF effects [PDF]
, 2015 The CRF system of the central nucleus of the amygdala (CeA) is important for the processing of anxiety, stress, and effects of acute and chronic ethanol.
CICCOCIOPPO, Roberto +7 more
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Bidirectional Control of Synaptic GABAAR Clustering by Glutamate and Calcium
Cell Reports, 2015 GABAergic synaptic transmission regulates brain function by establishing the appropriate excitation-inhibition (E/I) balance in neural circuits.
Hiroko Bannai +9 more
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N-methyl-D-aspartate receptors play important roles in acquisition and expression of the eyeblink conditioned response in glutamate receptor subunit delta2 mutant mice. [PDF]
, 2005 Classical eyeblink conditioning has been known to depend critically on the cerebellum. Apparently consistent with this, glutamate receptor subunit delta2 null mutant mice, which have serious morphological and functional deficiencies in the cerebellar ...
Fukunaga Satoshi +6 more
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Cross-talk and regulation between glutamate and GABAB receptors
Frontiers in Cellular Neuroscience, 2015 Brain function depends on co-ordinated transmission of signals from both excitatory and inhibitory neurotransmitters acting upon target neurons.
Sriharsha eKantamneni
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Glutamate may be an efferent transmitter that elicits inhibition in mouse taste buds. [PDF]
PLoS ONE, 2012 Recent studies suggest that l-glutamate may be an efferent transmitter released from axons innervating taste buds. In this report, we determined the types of ionotropic synaptic glutamate receptors present on taste cells and that underlie this postulated
Yijen A Huang, Jeff Grant, Stephen Roper
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